Pain Memory: Assessment and Clinical Implications

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Sensory and Motor Neuroscience".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 786

Special Issue Editors

Special Issue Information

Dear Colleagues,

The memory of pain is defined as the memory trace resulting from the collection and processing of painful information. The current literature regarding the memory of pain encompasses both the recollection of pain intensity and the memory of the unpleasant sensation associated with pain. The memory of pain holds significant importance as it influences subsequent painful experiences. It is also known that the chronicity of pain is related to the existence of attentional avoidance of painful information, the tendency to overestimate past pain and high levels of depression. The importance of the memory of pain in chronic pain is so significant, that some authors define this type of pain as the persistence of painful recollection and/or the inability to eliminate the memory of pain established by an initial injury.

To this end, we welcome any methodological design, including systematic reviews/meta-analysis, clinical trials, observational studies, pilot studies, and even case series and case reports. 

Dr. Ferran Cuenca-Martínez
Dr. Núria Sempere-Rubio
Guest Editors

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Keywords

  • pain memory
  • psychosocial
  • pain chronification
  • pain medicine
  • pain assessment
  • pain neuroscience

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Published Papers (1 paper)

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Review

14 pages, 723 KiB  
Review
Methodological Approaches to Pain Memory Assessment in Chronic Pain: A Scoping Review
by Carlos Forner-Álvarez and Ferran Cuenca-Martínez
Brain Sci. 2025, 15(3), 308; https://doi.org/10.3390/brainsci15030308 - 14 Mar 2025
Viewed by 480
Abstract
Background/Objectives: Pain memory refers to the ability to encode, store, and recall information related to a specific pain event. Reviewing its common features is crucial, as it provides researchers with a foundational guide for designing studies that assess pain memory in individuals with [...] Read more.
Background/Objectives: Pain memory refers to the ability to encode, store, and recall information related to a specific pain event. Reviewing its common features is crucial, as it provides researchers with a foundational guide for designing studies that assess pain memory in individuals with chronic pain. The primary objective of this study was to examine the common characteristics—particularly the methodological approaches—of existing research on pain memory in adults with chronic pain. Methods: A scoping review was conducted using PubMed and Embase as search databases. Studies were included if they met the following criteria. (a) It involved only adults with chronic pain and (b) assessed at least one of the following parameters: pain intensity or pain unpleasantness. The exclusion criteria were the following: (a) not having pain memory assessment as a primary objective, (b) including participants under 18 years of age, (c) involving individuals without chronic pain (e.g., those with acute pain or healthy participants), (d) lacking essential information, or (e) unavailability of the full text. Results: From an initial pool of 4585 papers, 11 studies met the inclusion criteria. All studies exclusively involved adults with chronic pain, and all reported pain intensity, while only 27% assessed pain unpleasantness. Additionally, psychosocial variables were the most frequently reported non-pain-related outcomes. Regarding study protocols, most relied on daily data collection, with the most common recall period being within the first 48 h. Conclusions: The methodological characteristics identified in this review—particularly those with a high frequency of occurrence—should serve as fundamental guidelines for future research on pain memory in adults with chronic pain, and should be carefully considered by investigators in this field. Full article
(This article belongs to the Special Issue Pain Memory: Assessment and Clinical Implications)
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