Interactions Between Intestinal Microbiota and Host
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 14
Special Issue Editor
Special Issue Information
Dear Colleagues,
The intestinal microbiota, incorporating bacteria, viruses, fungi, protozoa, and archaea, plays a pivotal role in host physiology and disease. Advances in metagenomics, metabolomics, and other multi-omics approaches have identified the microbiota as a central modulator of metabolism, immunity, and barrier function. Despite these insights, the molecular mechanisms underlying host–microbiome interactions remain only partially understood.
Disruption of the microbial balance—termed dysbiosis—has been linked to inflammatory, metabolic, autoimmune, and neurodegenerative diseases, including inflammatory bowel disease (IBD). Elucidating the molecular and cellular basis of these interactions is critical for advancing the understanding of host–microbiome interplay, identifying novel therapeutic targets or biomarkers.
This Special Issue aims to comprise an overview of current advances of host–microbiome interactions in both health and disease. We invite original research articles, reviews, and short communications addressing, but not limited to, the following topics:
- Mechanistic studies of host–microbiome crosstalk in in vitro, ex vitro, and in vivo models;
- The role of the microbiota in inflammatory and immune-mediated diseases;
- Microbial metabolites and signaling pathways modulating host responses;
- Multi-omics and systems biology approaches to host–microbiome networks;
- Microbiome-targeted interventions and therapeutics.
Dr. Kaline Arnauts
Guest Editor
Manuscript Submission Information
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Keywords
- host–microbiome interactions
- dysbiosis
- metagenomics
- microbiome therapeutics
- metabolites
- multi-omics
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