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Journal of Personalized Medicine, Volume 15, Issue 5

May 2025 - 52 articles

Cover Story: Breast cancer is the most common malignancy and the leading cause of death from cancer in women worldwide. In many high‐income countries’ mortality rates have decreased since the early 1990s, following new developments in early detection by screening and progress in treatment. Modern high-throughput proteomic analysis methods emerged at the end of the last century, and since then, they have been widely used in breast cancer research. Still, in contrast to genomic analyses, it is not clear to clinicians whether proteomic-based methods have any clinical applications in breast cancer diagnosis and therapy. Hence, the aim of the present scoping review was to investigate and delineate the current role and possible emerging clinical applications of proteomic analyses in personalized diagnostic evaluation and treatment of breast cancer patients. View this paper
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Articles (52)

  • Review
  • Open Access
3,797 Views
19 Pages

Interstitial Lung Diseases and Lung Cancer: A Review on Similarities, Common Pathogenesis and Therapeutic Approach

  • Gioele Castelli,
  • Elisabetta Cocconcelli,
  • Giuliana Grimaudo,
  • Irene Di Leo,
  • Serena Bellani,
  • Giordano Fiorentù,
  • Giacomo Giulianelli,
  • Nicol Bernardinello,
  • Elisabetta Balestro and
  • Paolo Spagnolo

Interstitial lung disease (ILD) prevalence and survival are increasing due to improvement in scientific research together with clinical complications typical of advanced disease. Lung cancer (LC) is described as a possible event occurring in lung par...

  • Article
  • Open Access
895 Views
11 Pages

Associations of PPARG and PPARGC1A Polymorphisms with Ritodrine-Induced Adverse Events in Patients with Preterm Labor

  • Eun Jeong Jang,
  • Da Hoon Lee,
  • Yubin Song,
  • Jung Sun Kim,
  • Young Ju Kim,
  • Jeong Yee and
  • Hye Sun Gwak

Objectives: Ritodrine, a tocolytic agent used to delay preterm labor, can cause several cardiovascular-associated adverse events (AEs). This study aimed to examine the relationship between gene polymorphisms in peroxisome proliferator-activated recep...

  • Review
  • Open Access
1 Citations
1,113 Views
10 Pages

Lactate as a Preoperative Predictor of Mortality in Patients Undergoing Emergency Type A Aortic Dissection Repair

  • Sombuddha Bhadra,
  • Rachel H. Drgastin,
  • Howard K. Song,
  • Frederick A. Tibayan,
  • Gurion Lantz,
  • Julie W. Doberne and
  • Castigliano M. Bhamidipati

Background: Aortic dissection is a life-threatening condition where emergent surgical repair is the standard of care. However, despite operative intervention, mortality is 10–15% in all patients. Objective markers to distinguish when surgical r...

  • Article
  • Open Access
2,300 Views
19 Pages

A Comprehensive Dataset for Activity of Daily Living (ADL) Research Compiled by Unifying and Processing Multiple Data Sources

  • Jaime Pabón,
  • Daniel Gómez,
  • Jesús D. Cerón,
  • Ricardo Salazar-Cabrera,
  • Diego M. López and
  • Bernd Blobel

Background: Activities of Daily Living (ADLs) are essential tasks performed at home and used in healthcare to monitor sedentary behavior, track rehabilitation therapy, and monitor chronic obstructive pulmonary disease. The Barthel Index, used by heal...

  • Article
  • Open Access
1 Citations
1,538 Views
11 Pages

Background/Objectives: To analyze corneal endothelial changes and intraocular pressure (IOP) after phacoemulsification combined with the eight-chop technique and intraoperative parameters in patients with diabetes mellitus. Methods: The eyes of patie...

  • Article
  • Open Access
898 Views
24 Pages

Comparative Evaluation of Automatic Detection and Classification of Daily Living Activities Using Batch Learning and Stream Learning Algorithms

  • Paula Sofía Muñoz,
  • Ana Sofía Orozco,
  • Jaime Pabón,
  • Daniel Gómez,
  • Ricardo Salazar-Cabrera,
  • Jesús D. Cerón,
  • Diego M. López and
  • Bernd Blobel

Background/Objectives: Activities of Daily Living (ADLs) are crucial for assessing an individual’s autonomy, encompassing tasks such as eating, dressing, and moving around, among others. Predicting these activities is part of health monitoring,...

  • Review
  • Open Access
2 Citations
13,611 Views
18 Pages

Point of View: A Holistic Four-Interface Conceptual Model for Personalizing Shock Resuscitation

  • Philippe Rola,
  • Eduardo Kattan,
  • Matthew T. Siuba,
  • Korbin Haycock,
  • Sara Crager,
  • Rory Spiegel,
  • Max Hockstein,
  • Vimal Bhardwaj,
  • Ashley Miller and
  • Jon-Emile Kenny
  • + 2 authors

The resuscitation of a patient in shock is a highly complex endeavor that should go beyond normalizing mean arterial pressure and protocolized fluid loading. We propose a holistic, four-interface conceptual model of shock that we believe can benefit...

  • Article
  • Open Access
1 Citations
1,441 Views
13 Pages

Features of Heart Failure with Preserved Ejection Fraction in Patients with Chronic Obstructive Pulmonary Disease and Systemic Sclerosis-Associated Interstitial Lung Diseases

  • Lyazat Ibrayeva,
  • Meruyert Aubakirova,
  • Irina Bacheva,
  • Assel Alina,
  • Nazira Bazarova,
  • Aizhan Zhanabayeva,
  • Olga Avdiyenko,
  • Seda Borchashvili,
  • Saltanat Tazhikhanova and
  • Askhat Murzabaeyev

Background/Objectives: This study aims to investigate the potential etiopathogenesis of HFpEF development and identify possible different phenotypes of HFpEF in patients with chronic obstructive pulmonary disease (COPD) and systemic sclerosis-associa...

  • Opinion
  • Open Access
31 Citations
1,999 Views
10 Pages

A Talk with ChatGPT: The Role of Artificial Intelligence in Shaping the Future of Cardiology and Electrophysiology

  • Angelica Cersosimo,
  • Elio Zito,
  • Nicola Pierucci,
  • Andrea Matteucci and
  • Vincenzo Mirco La Fazia

Background: Artificial intelligence (AI) is poised to significantly impact the future of cardiology and electrophysiology, offering new tools to interpret complex datasets, improve diagnosis, optimize clinical workflows, and personalize therapy. Chat...

  • Article
  • Open Access
1 Citations
978 Views
13 Pages

High Ocular Disease Burden and Increased Referral Needs in Patients with Chronic Kidney Disease: A Step Toward Personalized Care

  • Yulia Liem,
  • Pavitra Thyagarajan,
  • Miao Li Chee,
  • Cynthia Ciwei Lim,
  • Boon Wee Teo and
  • Charumathi Sabanayagam

Background/Objectives: To evaluate the prevalence of eye diseases in patients with confirmed chronic kidney disease (CKD) and their referral patterns to ophthalmologists, with the aim of informing personalized screening and referral strategies. Metho...

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J. Pers. Med. - ISSN 2075-4426