Next Article in Journal
PRP Therapy for Stress Urinary Incontinence and Pelvic Organ Prolapse: A New Frontier in Personalized Treatment?
Next Article in Special Issue
Pathology and Molecular Diagnostics in the Personalized Treatment of Lung Diseases
Previous Article in Journal
Associations of PPARG and PPARGC1A Polymorphisms with Ritodrine-Induced Adverse Events in Patients with Preterm Labor
Previous Article in Special Issue
Clinicopathological Features of Non-Small Cell Lung Carcinoma with NRAS Mutation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JPM
Volume 15
Issue 5
10.3390/jpm15050213
jpm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Interstitial Lung Diseases and Lung Cancer: A Review on Similarities, Common Pathogenesis and Therapeutic Approach

by
Gioele Castelli
1,
Elisabetta Cocconcelli
1,
Giuliana Grimaudo
1,
Irene Di Leo
2,
Serena Bellani
1,
Giordano Fiorentù
1,
Giacomo Giulianelli
1,
Nicol Bernardinello
1,
Elisabetta Balestro
1 and
Paolo Spagnolo
1,*
1
Respiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova and Padova City Hospital, 35128 Padua, Italy
2
Division of Respiratory Medicine, Department PROMISE, “Paolo Giaccone” University Hospital, University of Palermo, 90133 Palermo, Italy
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2025, 15(5), 213; https://doi.org/10.3390/jpm15050213
Submission received: 17 March 2025 / Revised: 12 May 2025 / Accepted: 20 May 2025 / Published: 21 May 2025
(This article belongs to the Special Issue Pathology and Molecular Diagnostics in the Personalized Treatment of Lung Diseases)
Browse Figure
Review Reports Versions Notes

Abstract

Interstitial lung disease (ILD) prevalence and survival are increasing due to improvement in scientific research together with clinical complications typical of advanced disease. Lung cancer (LC) is described as a possible event occurring in lung parenchyma in the context of fibrotic abnormalities that worsen patients’ prognosis. This growth of malignant cells on a fibrotic background has also been called scar-cinoma. For this reason, not only an early diagnosis but also personalized decisions on the best treatment approach should be considered for each patient in a multidisciplinary discussion, since in some cases chemotherapy or surgery could be detrimental for patients with pulmonary fibrosis. LC and lung fibrosis may share common pathogenetic mechanisms like an altered healing process in response to repeated tissue damage from environmental exposure in genetically susceptible individuals. Smoking history and air pollution together with mutations in telomere and surfactant protein genes lead to the production of cytokines and nitro derivatives in the microenvironment that facilitate the carcinomatous transformation during fibrogenesis. The evolution of LC therapy and the implementation of immunotherapy acting on targetable immune checkpoints have raised interest in evaluating ILD-LC actionable mutations. The main pathogenetic mechanisms, clinical presentations and treatment implications are presented in this review.
Keywords: idiopathic pulmonary fibrosis; interstitial lung diseases; lung cancer; lung cancer treatment; chemotherapy; immunotherapy; palliative care idiopathic pulmonary fibrosis; interstitial lung diseases; lung cancer; lung cancer treatment; chemotherapy; immunotherapy; palliative care

Share and Cite

MDPI and ACS Style

Castelli, G.; Cocconcelli, E.; Grimaudo, G.; Di Leo, I.; Bellani, S.; Fiorentù, G.; Giulianelli, G.; Bernardinello, N.; Balestro, E.; Spagnolo, P. Interstitial Lung Diseases and Lung Cancer: A Review on Similarities, Common Pathogenesis and Therapeutic Approach. J. Pers. Med. 2025, 15, 213. https://doi.org/10.3390/jpm15050213

AMA Style

Castelli G, Cocconcelli E, Grimaudo G, Di Leo I, Bellani S, Fiorentù G, Giulianelli G, Bernardinello N, Balestro E, Spagnolo P. Interstitial Lung Diseases and Lung Cancer: A Review on Similarities, Common Pathogenesis and Therapeutic Approach. Journal of Personalized Medicine. 2025; 15(5):213. https://doi.org/10.3390/jpm15050213

Chicago/Turabian Style

Castelli, Gioele, Elisabetta Cocconcelli, Giuliana Grimaudo, Irene Di Leo, Serena Bellani, Giordano Fiorentù, Giacomo Giulianelli, Nicol Bernardinello, Elisabetta Balestro, and Paolo Spagnolo. 2025. "Interstitial Lung Diseases and Lung Cancer: A Review on Similarities, Common Pathogenesis and Therapeutic Approach" Journal of Personalized Medicine 15, no. 5: 213. https://doi.org/10.3390/jpm15050213

APA Style

Castelli, G., Cocconcelli, E., Grimaudo, G., Di Leo, I., Bellani, S., Fiorentù, G., Giulianelli, G., Bernardinello, N., Balestro, E., & Spagnolo, P. (2025). Interstitial Lung Diseases and Lung Cancer: A Review on Similarities, Common Pathogenesis and Therapeutic Approach. Journal of Personalized Medicine, 15(5), 213. https://doi.org/10.3390/jpm15050213

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop