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Diagnostics, Volume 10, Issue 4

April 2020 - 75 articles

Cover Story: The differential diagnosis in Interstitial Lung Diseases (ILDs) can be challenging due to the large number of possible causes. Autoimmune Diseases (ADs) are a common cause of ILD, not always easy to recognize. Rheumatologists are rarely involved in diagnostic Multi-Disciplinary Teams for ILD and patients generally refer to pulmonologists for their symptoms. High-Resolution Computed Tomography can help the diagnosis in presence of Nonspecific Interstitial Pneumonia pattern, but ADs are able to produce all possible ILD patterns, alone or even combined. In this scenario, auto-antibodies can have a great value, although patients can be seronegative, and myositis-specific antibodies are still not widely diffused in clinical practice. Moreover, systemic symptoms and signs are frequently nuanced and may not be noticed by non-trained physicians. Hereby, we discuss elements suggestive for ADs-ILD, reporting our methodology. View this paper
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Articles (75)

  • Article
  • Open Access
5 Citations
4,935 Views
9 Pages

Unstimulated Parotid Saliva Sampling in Juvenile Idiopathic Arthritis and Healthy Controls: A Proof-of-Concept Study on Biomarkers

  • Alexandra Dimitrijevic Carlsson,
  • Bijar Ghafouri,
  • Carin Starkhammar Johansson and
  • Per Alstergren

The aims of this proof-of-concept study were to develop a collecting method for unstimulated parotid saliva in juvenile idiopathic arthritis (JIA) patients and healthy children and to investigate if inflammatory biomarkers could be detected in these...

  • Article
  • Open Access
25 Citations
5,746 Views
15 Pages

A Prospective Study Comparing Three-Dimensional Rectal Water Contrast Transvaginal Ultrasonography and Computed Tomographic Colonography in the Diagnosis of Rectosigmoid Endometriosis

  • Fabio Barra,
  • Ennio Biscaldi,
  • Carolina Scala,
  • Antonio Simone Laganà,
  • Valerio Gaetano Vellone,
  • Cesare Stabilini,
  • Fabio Ghezzi and
  • Simone Ferrero

(1) Objectives: In patients with symptoms suggestive of rectosigmoid endometriosis, imaging techniques are required to confirm the presence and establish the extent of the disease. The objective of the current study was to compare the performance of...

  • Article
  • Open Access
20 Citations
6,077 Views
12 Pages

Thyroid Pathology in End-Stage Renal Disease Patients on Hemodialysis

  • Laura Cotoi,
  • Florin Borcan,
  • Ioan Sporea,
  • Daniela Amzar,
  • Oana Schiller,
  • Adalbert Schiller,
  • Cristina A. Dehelean,
  • Gheorghe Nicusor Pop,
  • Andreea Borlea and
  • Dana Stoian

Objectives: Chronic kidney disease is a rising cause of morbidity and mortality in developed countries, including end-stage renal disease (ESRD). The prevalence of thyroid comorbidities in persons with chronic kidney disease is documented higher than...

  • Article
  • Open Access
5 Citations
3,151 Views
10 Pages

Increased Tissue Expression of Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Is Associated with Disease Severity in Chronic Rhinosinusitis with Nasal Polyps

  • Manabu Nishida,
  • Sachio Takeno,
  • Kohta Takemoto,
  • Daisuke Takahara,
  • Takao Hamamoto,
  • Takashi Ishino and
  • Tomohiro Kawasumi

Background: The oxidative stress, induced by both environmental and intrinsic stimuli, underlies the onset and persistency of chronic rhinosinusitis (CRS). Scavenger receptors (SRs) are a broad family of transmembrane receptors involved in a dysfunct...

  • Article
  • Open Access
18 Citations
4,888 Views
12 Pages

Magnetic Resonance Imaging Derived Biomarkers of IDH Mutation Status and Overall Survival in Grade III Astrocytomas

  • Paola Feraco,
  • Antonella Bacci,
  • Patrizia Ferrazza,
  • Luc van den Hauwe,
  • Riccardo Pertile,
  • Salvatore Girlando,
  • Mattia Barbareschi,
  • Cesare Gagliardo,
  • Alessio Giuseppe Morganti and
  • Benedetto Petralia

The evaluation of the isocitrate dehydrogenase (IDH) mutation status in the glioma decision-making process has diagnostic, prognostic and therapeutic implications. The aim of this study was to evaluate whether conventional magnetic resonance imaging...

  • Review
  • Open Access
97 Citations
14,641 Views
16 Pages

Dried Blood Spot in Laboratory: Directions and Prospects

  • Kristina Malsagova,
  • Artur Kopylov,
  • Alexander Stepanov,
  • Tatyana Butkova,
  • Alexander Izotov and
  • Anna Kaysheva

Over the past few years, dried blood spot (DBS) technology has become a convenient tool in both qualitative and quantitative biological analysis. DBS technology consists of a membrane carrier (MC) on the surface of which a biomaterial sample becomes...

  • Article
  • Open Access
18 Citations
5,866 Views
12 Pages

We investigated the size-based isolation and enumeration of circulating tumor cells (CTCs) using a centrifugal microfluidic device equipped with a fluid-assisted separation technology (FAST) disc. We further assessed the correlations among CTCs, canc...

  • Article
  • Open Access
61 Citations
5,717 Views
17 Pages

Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel

  • Dario de Biase,
  • Giorgia Acquaviva,
  • Michela Visani,
  • Viviana Sanza,
  • Chiara M. Argento,
  • Antonio De Leo,
  • Thais Maloberti,
  • Annalisa Pession and
  • Giovanni Tallini

Next generation sequencing (NGS) allows parallel sequencing of multiple genes at a very high depth of coverage. The need to analyze a variety of targets for diagnostic/prognostic/predictive purposes requires multi-gene characterization. Multi-gene pa...

  • Guidelines
  • Open Access
79 Citations
30,802 Views
23 Pages

ISIDOG Recommendations Concerning COVID-19 and Pregnancy

  • Francesca Donders,
  • Risa Lonnée-Hoffmann,
  • Aristotelis Tsiakalos,
  • Werner Mendling,
  • José Martinez de Oliveira,
  • Philippe Judlin,
  • Fengxia Xue,
  • Gilbert G. G. Donders and
  • ISIDOG COVID-19 Guideline Workgroup

Providing guidelines to health care workers during a period of rapidly evolving viral pandemic infections is not an easy task, but it is extremely necessary in order to coordinate appropriate action so that all patients will get the best possible car...

  • Review
  • Open Access
38 Citations
20,756 Views
16 Pages

HRCT Patterns of Drug-Induced Interstitial Lung Diseases: A Review

  • Giulio Distefano,
  • Luigi Fanzone,
  • Monica Palermo,
  • Francesco Tiralongo,
  • Salvatore Cosentino,
  • Corrado Inì,
  • Federica Galioto,
  • Ada Vancheri,
  • Sebastiano E. Torrisi and
  • Letizia A. Mauro
  • + 4 authors

Interstitial Lung Diseases (ILDs) represent a heterogeneous group of pathologies, which may be related to different causes. A low percentage of these lung diseases may be secondary to the administration of drugs or substances. Through the PubMed data...

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Diagnostics - ISSN 2075-4418