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Diagnostics, Volume 10, Issue 3

March 2020 - 53 articles

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Cover Story: 18F-FLT PET/CT has been used in response assessment of neoadjuvant chemotherapy in soft-tissue sarcomas, but never in early response to systematically targeted therapies. In this pilot work, 18F-FLT PET/CT was studied for early response evaluation in patients with sarcomas receiving two new therapies: mdm2-inhibitor or c-met-inhibitor. An early response was observed within 1–4 weeks in patients who responded (8 out of 15), and new response criteria for these patients could be developed. View this paper.

Articles (53)

  • Article
  • Open Access
17 Citations
4,009 Views
14 Pages

Glioblastoma (GBM), the most common and aggressive brain tumor, has a very poor outcome and high tumor recurrence rate. The immune system has positive interactions with the central nervous system. Despite many studies investigating immune prognostic...

  • Article
  • Open Access
7 Citations
4,840 Views
11 Pages

Introduction: Traumatic brain injuries (TBI) are a real social problem, with an upward trend worldwide. The most frequent consequence of a traumatic brain injury is extra-axial hemorrhage, i.e., an acute subdural (SDH) and epidural hematoma (EDH). Mo...

  • Case Report
  • Open Access
9 Citations
10,889 Views
7 Pages

Acute subdural hematoma (aSDH) is a common pathology encountered after head trauma. Only a minority of aSDHs have an arterial source. In this article, we report a case of aSDH originating from a traumatic pseudoaneurysm of the distal segment of poste...

  • Article
  • Open Access
22 Citations
4,238 Views
13 Pages

Platelet Mitochondrial Respiration, Endogenous Coenzyme Q10 and Oxidative Stress in Patients with Chronic Kidney Disease

  • Anna Gvozdjáková,
  • Zuzana Sumbalová,
  • Jarmila Kucharská,
  • Mária Komlósi,
  • Zuzana Rausová,
  • Oľga Vančová,
  • Monika Számošová and
  • Viliam Mojto

Chronic kidney disease (CKD) is characterized by a progressive loss of renal function and a decrease of glomerular filtration rate. Reduced mitochondrial function, coenzyme Q10 (CoQ10), and increased oxidative stress in patients with CKD contribute t...

  • Article
  • Open Access
7 Citations
5,230 Views
9 Pages

Simultaneous Measurement of Gastric Emptying of a Soup Test Meal Using MRI and Gamma Scintigraphy

  • Asseel Khalaf,
  • Caroline L. Hoad,
  • Elaine Blackshaw,
  • Jaber Alyami,
  • Robin C. Spiller,
  • Penny A. Gowland,
  • Vidhiya Vinayaka-Moorthy,
  • Alan C. Perkins,
  • Gordon W. Moran and
  • Luca Marciani

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS sh...

  • Article
  • Open Access
119 Citations
5,958 Views
13 Pages

GRB10 and E2F3 as Diagnostic Markers of Osteoarthritis and Their Correlation with Immune Infiltration

  • Ya-Jun Deng,
  • En-Hui Ren,
  • Wen-Hua Yuan,
  • Guang-Zhi Zhang,
  • Zuo-Long Wu and
  • Qi-Qi Xie

This study aimed to find potential diagnostic markers for osteoarthritis (OA) and analyze the role of immune cells infiltration in this pathology. We used OA datasets from the Gene Expression Omnibus database. First, R software was used to identify d...

  • Article
  • Open Access
10 Citations
3,857 Views
10 Pages

Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

  • Tsuguru Hayashi,
  • Nobuharu Tamaki,
  • Masayuki Kurosaki,
  • Wan Wang,
  • Mao Okada,
  • Mayu Higuchi,
  • Kenta Takaura,
  • Hitomi Takada,
  • Yutaka Yasui and
  • Kaoru Tsuchiya
  • + 4 authors

Background: A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. Methods: The measurement of serum fibro...

  • Review
  • Open Access
65 Citations
11,143 Views
21 Pages

Diagnosis of Mucopolysaccharidoses

  • Francyne Kubaski,
  • Fabiano de Oliveira Poswar,
  • Kristiane Michelin-Tirelli,
  • Maira Graeff Burin,
  • Diana Rojas-Málaga,
  • Ana Carolina Brusius-Facchin,
  • Sandra Leistner-Segal and
  • Roberto Giugliani

The mucopolysaccharidoses (MPSs) include 11 different conditions caused by specific enzyme deficiencies in the degradation pathway of glycosaminoglycans (GAGs). Although most MPS types present increased levels of GAGs in tissues, including blood and...

  • Article
  • Open Access
4 Citations
4,395 Views
14 Pages

Cross-Cultural Adaptation of the Dance Functional Outcome Survey (DFOS) for Spanish Dancers

  • Blanca de-la-Cruz-Torres,
  • Irene Barrera-García-Martín,
  • Carlos Romero-Morales and
  • Shaw Bronner

A growing number of research papers regarding Spanish-speaking dancers justifies the need for an adapted Spanish version of the Dance Functional Outcome Survey (DFOS). The objective of this study was to cross-culturally adapt and validate the DFOS fo...

  • Case Report
  • Open Access
8 Citations
3,819 Views
14 Pages

Multiple primary malignant tumors are defined by the development of more than one malignancy in a single patient. These can be subdivided into synchronous or metachronous malignant tumors, depending on their time of appearance, relative to the first...

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