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Open AccessArticle

Magnetic Resonance Imaging Derived Biomarkers of IDH Mutation Status and Overall Survival in Grade III Astrocytomas

1
Neuroradiology Unit, S. Chiara Hospital, Trento, Largo Medaglie d’oro 9, 38122 Trento, Italy
2
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via San Giacomo 14, 40122 Bologna, Italy
3
Department of Neuroradiology, Ospedale Bellaria, IRCSS Istituto delle Scienze Neurologiche, Via Altura, 9 40100 Bologna, Italy
4
Radiation Oncology Unit, APSS, Largo Medaglie d’oro 9, 38122 Trento, Italy
5
Department of Radiology, University of Antwerp, Wilrijkstraat 10, B2650 Edegem (Antwerp), Belgium
6
Clinical and Evaluative Epidemiology Department-Trento Health Service, Trento, Via de Gasperi 79, 38100 Trento, Italy
7
Pathology Unit, S. Chiara Hospital, Largo Medaglie d’oro 9, 38122 Trento, Italy
8
Section of Radiological Sciences, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Via Del Vespro 129, 90127 Palermo, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(4), 247; https://doi.org/10.3390/diagnostics10040247
Received: 20 March 2020 / Revised: 16 April 2020 / Accepted: 21 April 2020 / Published: 23 April 2020
(This article belongs to the Special Issue Molecular Diagnostics of CNS Tumours)
The evaluation of the isocitrate dehydrogenase (IDH) mutation status in the glioma decision-making process has diagnostic, prognostic and therapeutic implications. The aim of this study was to evaluate whether conventional magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) can noninvasively predict the most common IDH mutational status (R132H) in GIII-astrocytomas and the overall survival (OS). Hence, twenty-two patients (9-F, 13-M) with a histological diagnosis of GIII-astrocytoma and evaluation of IDH-mutation status (12-wild type, 10-mutant) were retrospectively evaluated. Imaging studies were reviewed for the morphological feature and mean ADC values (ADCm). Statistics included a Fisher’s exact test, Student’s t-test, Spearman’s Test and receiver operating characteristic analysis. A p ≤ 0.05 value was considered statistically significant for all the tests. A younger age and a frontal location were more likely related to mutational status. IDH-wild type (Wt) exhibited a slight enhancement (p = 0.039). The ADCm values in IDH-mutant (Mut) patients were higher than those of IDH-Wt patients (p < 0.0004). The value of ADC ≥ 0.99 × 10−3 mm2/s emerged as a “cut-off” to differentiate the mutation state. In the overall group, a positive relationship between the ADCm values and OS was detected (p = 0.003; r = 0.62). Adding quantitative measures of ADC values to conventional MR imaging could be used routinely as a noninvasive marker of specific molecular patterns. View Full-Text
Keywords: isocitrate dehydrogenase (IDH) mutation; diffusion weighted imaging (DWI); apparent diffusion coefficient (ADC); anaplastic astrocytomas; overall survival; radiogenomics isocitrate dehydrogenase (IDH) mutation; diffusion weighted imaging (DWI); apparent diffusion coefficient (ADC); anaplastic astrocytomas; overall survival; radiogenomics
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Feraco, P.; Bacci, A.; Ferrazza, P.; van den Hauwe, L.; Pertile, R.; Girlando, S.; Barbareschi, M.; Gagliardo, C.; Morganti, A.G.; Petralia, B. Magnetic Resonance Imaging Derived Biomarkers of IDH Mutation Status and Overall Survival in Grade III Astrocytomas. Diagnostics 2020, 10, 247.

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