Molecular Diagnostics of CNS Tumours

Dear Colleagus,

The World Health Organization (WHO) classification system of central nervous system (CNS) tumors was revised in 2016 according to an integrated diagnosis based both on morphology and of molecular genetics. In the last decade, next-generation sequencing led to the discovery of new molecular markers with both diagnostic and prognostic relevance. On the one side, these new findings have improved the current knowledge of the molecular basis of both adult and paediatric brain tumors and, on the other side, they have significantly affected their clinical management. Compelling evidence has demonstrated the critical role played by the molecular pattern of brain tumors on the final clinical outcome. This Special Issue aims to increase the knowledge of molecular biomarkers involved in the origin and progression of brain tumors (or the molecular basis) in order to improve the current diagnostic algorithms for molecular genetic tests in brain tumors in the neuropathological and neuro-oncological practice for an accurate diagnosis and appropriate management. This Special Issue is open to original contributions from experimental and clinical studies, including reports on improved experimental models and innovative therapies. We are particularly interested in articles describing new insights into pathogenetic mechanisms, conveying potentially useful insights to achieve original diagnostic and therapeutic approaches. Potential topics include but are not limited to the following:

• Low-grade gliomas;
• Glioblastoma and midline gliomas;
• Meningiomas;
• Brain metastases;
• Paediatric brain tumors.

Prof. Dr. Renzo Boldorini
Guest Editor

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