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Life, Volume 15, Issue 6

June 2025 - 157 articles

Cover Story: Clozapine remains the leading drug for treatment-resistant schizophrenia, yet its complex pharmacology, inconsistent efficacy, and adverse side effects hinder its adoption. In this review, we collate clinical, imaging, and molecular findings from 2013 to 2025 to address at least three factors: how clozapine’s rapid D2 drop-off but high affinity for D4, 5-HT2A/C, muscarinic, H1, and α1 receptors drives NMDA signaling, kynurenine turnover, mTOR-S6 translation, and cortical perfusion; when additional therapies such as paliperidone, amisulpride, memantine, minocycline, or rTMS rescue partial responders; and how plasma metabolite ratios, neurotrophins, brain morphometry, pharmacogenes, and polygenic risk scores can predict response and guide safer dosing. This article interweaves these strands to chart a path toward personalized, high-benefit, low-risk clozapine care. View this paper
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Articles (157)

  • Article
  • Open Access
1 Citations
2,762 Views
15 Pages

18 June 2025

This study aimed to explore the independent and interactive effects of varying squat depths and movement speeds on dynamic postural stability during the Part the Wild Horse’s Mane (PWHM) movement. Thirteen male participants (age: 25.86 ±...

  • Article
  • Open Access
1,644 Views
9 Pages

18 June 2025

Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) and concomitant interstitial lung disease (ILD) are particularly challenging to manage due to concerns about ventilation–perfusion mismatch with system...

  • Systematic Review
  • Open Access
3,134 Views
12 Pages

Intravenous Magnesium Sulphate as an Adjuvant Therapy for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

  • Taimur Farid,
  • Abdousamad Said Omar,
  • Sijah Varar Kandi,
  • Soja Puthiyara Maliyekal,
  • Tze Quan Tuen,
  • Amrutha Thazhuthedath Vijayan,
  • Lakshmi Sudhir Pillai,
  • Ahmed Talaat Deiab,
  • Muhammad Sajid and
  • Ahmad Mesmar
  • + 6 authors

18 June 2025

Background: Intravenous magnesium sulfate (IV MgSO4) may serve as an effective adjunct therapy to improve clinical outcomes in patients experiencing acute exacerbations of chronic obstructive pulmonary disease (AECOPDs). Methods: A comprehensive sear...

  • Article
  • Open Access
1,055 Views
21 Pages

18 June 2025

This study investigated the effects of land-use change and wetland restoration on soil microbial community diversity, structure, and function in a cold-region wetland ecosystem. Soil samples from six land-use types were analyzed for key physicochemic...

  • Article
  • Open Access
1 Citations
1,115 Views
13 Pages

The Platelet-to-Lymphocyte Ratio (PLR) as a Non-Invasive Biomarker for Cervical Malignancy in Conization Patients

  • Noémi Kalas,
  • Verita Szabó,
  • Balázs Vida,
  • Zsófia Tóth,
  • Lotti Lőczi,
  • Barbara Sebők,
  • Petra Merkely,
  • Balázs Lintner,
  • Nándor Ács and
  • Attila Keszthelyi
  • + 3 authors

18 June 2025

Background: Cervical cancer continues to pose a significant global health challenge, particularly in low-resource regions with limited access to advanced diagnostics. Cervical conization can occasionally uncover invasive carcinoma in patients initial...

  • Article
  • Open Access
2 Citations
1,210 Views
12 Pages

Differential Analysis of Hemogram Parameters and Cellular Ratios in Severe Asthma Exacerbations: A Comparative Study of Eosinophilic and Non-Eosinophilic Phenotypes

  • Nicolae Demenciuc,
  • Corina Eugenia Budin,
  • Corina Ureche,
  • Mircea Stoian,
  • Teodora Nicola-Varo,
  • Dragos-Florin Baba,
  • Dariana-Elena Pătrîntașu and
  • Diana Deleanu

18 June 2025

Asthma exacerbations are acute worsening episodes in individuals with bronchial asthma, frequently necessitating emergency hospital care. Early differentiation between eosinophilic (≥150 eosinophils/mm3) and non-eosinophilic (<150 eosinophils/m...

  • Article
  • Open Access
1,783 Views
14 Pages

18 June 2025

In practice, many patients receive APAP treatment for the simple reason that it provides increased comfort and is easier for patients to accept and tolerate. Reality has proven that we have very many patients diagnosed with OSAS on APAP treatment, un...

  • Article
  • Open Access
2 Citations
2,681 Views
15 Pages

Childhood Obesity and Overweight Are Associated with Higher Risk of Depression and Anxiety: A Cross-Sectional Study in Children Aged 6–9 Years

  • Konstantinos Papadimitriou,
  • Maria Mentzelou,
  • Sousana K. Papadopoulou,
  • Georgios Antasouras,
  • Georgia-Eirini Deligiannidou,
  • Olga Alexatou,
  • Apostolia Ntovoli,
  • Evmorfia Psara,
  • Vasiliki G. Papadopoulou and
  • Constantinos Giaginis

18 June 2025

Background/Objectives: The global prevalence of childhood obesity and overweight is steadily increasing, representing a pressing public health concern due to its persistence during adolescence and adulthood and its association with elevated morbidity...

  • Article
  • Open Access
1 Citations
1,493 Views
23 Pages

Novel Acylated Naringin Enhances Propionate Release and Stimulates the Growth of Flavanone-Metabolizing Bacteria in an In Vitro Batch Fermentation Model

  • Blanca Elizabeth Ruiz-Álvarez,
  • José Daniel Padilla-de la Rosa,
  • Marisela González Avila,
  • Georgina Sandoval and
  • Yves Desjardins

17 June 2025

The increasing prevalence of non-communicable diseases (NCDs) is strongly associated with gut microbiota (GM) imbalances and reduced short-chain fatty acid (SCFA) production, primarily driven by poor diet and microbial dysbiosis. Since SCFAs are cruc...

  • Article
  • Open Access
3,835 Views
20 Pages

17 June 2025

The abdominal drawing-in maneuver (ADIM) is one of the most valuable exercises for explicitly targeting and strengthening the transversus abdominis (TrA), a key muscle in the deep core. However, using the ADIM for the selective training of the transv...

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Life - ISSN 2075-1729