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Life, Volume 15, Issue 6

June 2025 - 157 articles

Cover Story: Clozapine remains the leading drug for treatment-resistant schizophrenia, yet its complex pharmacology, inconsistent efficacy, and adverse side effects hinder its adoption. In this review, we collate clinical, imaging, and molecular findings from 2013 to 2025 to address at least three factors: how clozapine’s rapid D2 drop-off but high affinity for D4, 5-HT2A/C, muscarinic, H1, and α1 receptors drives NMDA signaling, kynurenine turnover, mTOR-S6 translation, and cortical perfusion; when additional therapies such as paliperidone, amisulpride, memantine, minocycline, or rTMS rescue partial responders; and how plasma metabolite ratios, neurotrophins, brain morphometry, pharmacogenes, and polygenic risk scores can predict response and guide safer dosing. This article interweaves these strands to chart a path toward personalized, high-benefit, low-risk clozapine care. View this paper
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Articles (157)

  • Review
  • Open Access
1 Citations
2,057 Views
14 Pages

Seronegative Sicca Syndrome: Diagnostic Considerations and Management Strategies

  • Yordanka M. Basheva-Kraeva,
  • Krasimir I. Kraev,
  • Petar A. Uchikov,
  • Maria I. Kraeva,
  • Bozhidar K. Hristov,
  • Nina St. Stoyanova,
  • Vesela T. Mitkova-Hristova,
  • Borislav Ivanov,
  • Stanislav S. Karamitev and
  • Nina Koleva
  • + 2 authors

17 June 2025

Seronegative sicca syndrome encompasses patients who present with xerostomia and/or keratoconjunctivitis sicca but lack anti-SSA/SSB antibodies and do not fulfill current classification criteria for primary Sjögren’s syndrome (pSS). Despit...

  • Review
  • Open Access
2 Citations
2,470 Views
16 Pages

The Junction of Allergic Inflammation and Atherosclerosis: Pathways and Clinical Implications—A Review

  • Mihaela Valcovici,
  • Mihai Sorin Iacob,
  • Abhinav Sharma,
  • Ana Maria Pah,
  • Lucretia Marin-Bancila,
  • Marcel Mihai Vaduva Berceanu,
  • Milan Daniel Velimirovici,
  • Anca-Raluca Dinu,
  • Simona Ruxanda Drăgan and
  • Nilima Rajpal Kundnani

16 June 2025

Background: Cardiovascular disorders, especially atherosclerosis, have been associated with allergic inflammation. In addition to traditional inflammatory responses, there is evidence that the development and instability of coronary artery plaque may...

  • Article
  • Open Access
951 Views
16 Pages

HISLIS: Histology, Sarcopenia, and Lung Inflammation Score—A New Perspective for Lung Cancer Patients?

  • Claudia Raluca Mariean,
  • Oana Mirela Tiucă,
  • Cristina Flavia Al-Akel and
  • Ovidiu Simion Cotoi

16 June 2025

Background: Since lung cancer remains a health problem worldwide and is the leading cause of cancer death, finding new tools that can help in the early identification of high-risk patients remains a key target. Methods: A retrospective descriptive st...

  • Article
  • Open Access
1,120 Views
17 Pages

OsMYBR1, a 1R-MYB Family Transcription Factor Regulates Starch Biosynthesis in Rice Endosperm

  • Kunyong Huang,
  • Long Chen,
  • Guiai Jiao,
  • Zheyan Ruan,
  • Xinwei Li,
  • Shaoqing Tang,
  • Peisong Hu and
  • Xiangjin Wei

16 June 2025

Starch is the primary component of the endosperm and plays a crucial role in rice quality. Although the enzymes involved in starch synthesis have been extensively studied, the transcription factors that regulate these enzymes remain largely unknown....

  • Article
  • Open Access
1,179 Views
14 Pages

Associations Between Shift Work, Sociodemographic and Lifestyle Characteristics, Body Measurements, and MASLD

  • Javier Tosoratto,
  • Pedro Juan Tárraga López,
  • Ángel Arturo López-González,
  • Carla Busquets-Cortes,
  • Joan Obrador de Hevia and
  • José Ignacio Ramirez-Manent

16 June 2025

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder worldwide and is closely linked to the components of metabolic syndrome. Shift work, through its disruption of circadian rhythms...

  • Article
  • Open Access
4 Citations
1,802 Views
15 Pages

The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities

  • Evelina Maria Gosav,
  • Daniela Maria Tanase,
  • Anca Ouatu,
  • Oana Nicoleta Buliga-Finis,
  • Diana Popescu,
  • Cristina Gena Dascalu,
  • Nicoleta Dima,
  • Minerva Codruta Badescu and
  • Ciprian Rezus

16 June 2025

Atrial fibrillation (AF) is one of the most common cardiac arrhythmias encountered globally, characterized by a pro-inflammatory pattern. This analysis evaluated the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patie...

  • Article
  • Open Access
2,419 Views
15 Pages

Alterations in the Morphology of the Testis and Epididymis Caused by the Consumption of Hyperlipidic Diets in Wistar Rats

  • Rosario Tarragó Castellanos,
  • Maria Mendoza Delgado,
  • Lorena Ruiz Valderrama,
  • Isabel Arrieta Cruz,
  • Edith Cortés Barberena,
  • Adriana Morales Otal,
  • Ernesto Rodríguez Tobón,
  • Ahiezer Rodríguez Tobón,
  • Javier Olvera Ramírez and
  • Edith Arenas Ríos

14 June 2025

Obesity is considered a metabolic disease, in which leptin is used as an indicator of energy in the body. This hormone, in turn, is related to the neuroendocrine regulation of the reproductive axis. However, leptin excess secretion due to obesity can...

  • Article
  • Open Access
1,468 Views
10 Pages

14 June 2025

Cultures of primary human nasal epithelial cells (hNECs) differentiated at the air–liquid interface (ALI) represent a sophisticated and widely used model of the human upper respiratory epithelium. Despite the availability of various cell cultur...

  • Article
  • Open Access
3,719 Views
19 Pages

Bladder p75NTR-Mediated Anti-Inflammatory Response via the TLR4/TRAF6/NF-κB Axis

  • Claudia Covarrubias,
  • Abubakr H. Mossa,
  • Laura R. Yan,
  • Benjamin Desormeau,
  • Philippe G. Cammisotto,
  • H. Uri Saragovi and
  • Lysanne Campeau

14 June 2025

Recurrent bacterial cystitis in women can lead to interstitial cystitis or bladder pain syndrome (IC/BPS). Activation of Toll-like receptor 4 (TLR4) by LPS can upregulate signaling of the pro-inflammatory receptor p75NTR. The aim of the presented stu...

  • Article
  • Open Access
1,233 Views
12 Pages

The Influence of Drinking Water Intake on Pollutant Levels in the Human Body: Evidence from NHANES Data

  • Chenxu Dai,
  • Ziyi Qian,
  • Linjie Yang,
  • Siyan Chen,
  • Hongfei Hu and
  • Xia Huo

13 June 2025

Most studies have focused on the levels of pollutants in drinking water and the health risks they pose. However, no studies have reported the effects of drinking water intake on pollutant levels in the human body. Therefore, this study collected data...

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Life - ISSN 2075-1729