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Life, Volume 15, Issue 5

May 2025 - 150 articles

Cover Story: This article reviews the mechanisms, preclinical results, and potential clinical opportunities of sonodynamic therapy (SDT) for malignant gliomas. SDT has been reported to have a synergistic effect when combining low-intensity ultrasound with the sonosensitizer protoporphyrin IX (PpIX), leading to significant potential in the targeted treatment of high-grade gliomas. Our research of the existing literature found that the sonodynamic effect of PpIX increases tumor immunogenicity and induces apoptosis. It appears that SDT with 5-aminolevulinc acid (5-ALA)—the prodrug of PpIX—holds potential for the treatment of malignant gliomas. This review enhances our understanding of the multifaceted possibilities of SDT for brain tumor patients. View this paper
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Articles (150)

  • Article
  • Open Access
1 Citations
847 Views
16 Pages

20 May 2025

Micro-computed tomography assessment of osteochondral microstructural properties of the distal femur and proximal tibia was comprehensively conducted to compare adult patients with knee rheumatoid arthritis (RA) and primary knee osteoarthritis (KOA),...

  • Article
  • Open Access
1,032 Views
18 Pages

20 May 2025

Retrogressive succession alters soil conditions and microbial community dynamics in cold-region wetlands, yet its ecological implications remain understudied. This study explored the structure and function of soil microbial communities across three s...

  • Article
  • Open Access
2,609 Views
13 Pages

Impact of Neuromuscular Fatigue on Dynamic Knee Valgus in Female Basketball Players

  • Beatriz B. Gomes,
  • Ricardo Cardoso,
  • Rui A. Fernandes and
  • Rui A. Ferreira

20 May 2025

Dynamic knee valgus is a biomechanical condition often linked to an increased risk of knee injuries, particularly in female athletes, due to greater hip adduction, internal rotation, and knee abduction during dynamic movements. This study aimed to as...

  • Article
  • Open Access
905 Views
11 Pages

Prevalence and Characteristics of Patients with Cystic Fibrosis-Related Diabetes in Croatia

  • Lora Stanka Kirigin Biloš,
  • Maja Baretić,
  • Andrea Vukić Dugac,
  • Krešimir Schoenwald,
  • Ivan Bambir,
  • Duška Tješić Drinković,
  • Nevena Krnić and
  • Velimir Altabas

20 May 2025

This study investigated the prevalence of cystic fibrosis-related diabetes (CFRD) in the Croatian cystic fibrosis (CF) population, the age at diagnosis, insulin requirements, and the relationship between age at diagnosis and other clinical parameters...

  • Article
  • Open Access
1 Citations
898 Views
14 Pages

Impact of Left Ventricular Mass on Mortality in Symptomatic Severe Aortic Stenosis: A Sex-Specific Analysis

  • Solange Desirée Avakian,
  • Flávio Tarasoutchi and
  • Antonio de Padua Mansur

20 May 2025

Aortic stenosis (AS) is a common and serious valvular disease in older adults, often leading to increased left ventricular mass (LVM) due to pressure overload. Excessive LVM is linked to adverse outcomes, but its sex-specific prognostic significance...

  • Article
  • Open Access
4 Citations
2,204 Views
14 Pages

Engineered Chlamydomonas reinhardtii Strains for Enhanced Astaxanthin Production

  • Federico Perozeni,
  • Margherita Angelini,
  • Matteo Ballottari and
  • Stefano Cazzaniga

20 May 2025

Microalgae have evolved a diverse carotenoid profile, enabling efficient light harvesting and photoprotection. Previous studies have demonstrated the feasibility of genome editing in the green algal model species Chlamydomonas reinhardtii, leading to...

  • Review
  • Open Access
1 Citations
3,969 Views
17 Pages

Milpa Diet for MASLD in Mesoamerican Populations: Feasibility, Advantages, and Future Perspectives

  • Aline Huerta-Álvarez,
  • Mariana Arellano,
  • Clyo Anahí Chávez-Méndez,
  • Paulina Carpinteyro-Espin,
  • Carmen Palacios-Reyes and
  • Juanita Pérez-Escobar

19 May 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease, linked closely to metabolic syndrome and rising obesity rates. Affecting up to 37% of the global adult population, MASLD prevalence is exc...

  • Case Report
  • Open Access
1,528 Views
9 Pages

Bilateral Choroidal Detachment Following Pseudophakic Cystoid Macular Edema Treatment with Oral Acetazolamide

  • Agnieszka Kudasiewicz-Kardaszewska,
  • Małgorzata Ozimek,
  • Tomasz Urbański and
  • Sławomir Cisiecki

19 May 2025

Aim: This case report presents an unusual instance of bilateral choroidal effusion following the oral administration of acetazolamide for the treatment of pseudophakic cystoid macular edema (PCME). Case Presentation: An 87-year-old Caucasian man expe...

  • Review
  • Open Access
2 Citations
2,203 Views
16 Pages

Complex Transfemoral Access During Transcatheter Aortic Valve Replacement: A Narrative Review of Management, Complexity Scores, and Alternative Access

  • Ioannis Skalidis,
  • Neila Sayah,
  • Thierry Unterseeh,
  • Thomas Hovasse,
  • Francesca Sanguineti,
  • Philippe Garot,
  • Youcef Lounes,
  • Antoinette Neylon and
  • Mariama Akodad

19 May 2025

Transcatheter aortic valve replacement (TAVR) has become a well-established treatment for severe aortic stenosis across all levels of surgical risk. While transfemoral access remains the default approach, complications arising from vascular access&md...

  • Article
  • Open Access
936 Views
17 Pages

19 May 2025

The effects of proline co-solvent on helix folding are explored through the single discrete coordinate of the number of helical hydrogen bonds. The analysis is based on multi-microsecond length molecular dynamics simulations of alanine-based helix-fo...

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Life - ISSN 2075-1729