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Life, Volume 15, Issue 4

April 2025 - 172 articles

Cover Story: New roles for immune cells, overcoming the classical cytotoxic response, have been highlighted by growing evidence. The immune cells, such as neutrophils, monocytes/macrophages, and eosinophils, are versatile cells involved in the release of web-like DNA structures called extracellular traps (ETs) which represent a relevant mechanism by which these cells prevent microbes’ dissemination. In this review, we discuss the release mechanisms and the double-edged sword role of ETs both in physiological and in pathological contexts. In addition, we evaluated some possible strategies to target ETs aimed at either preventing their formation or degrading existing ones. View this paper
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Articles (172)

  • Article
  • Open Access
2 Citations
1,603 Views
9 Pages

The Role of Polysomnography for Children with Attention-Deficit/Hyperactivity Disorder

  • Chien-Heng Lin,
  • Po-Yen Wu,
  • Syuan-Yu Hong,
  • Yu-Tzu Chang,
  • Sheng-Shing Lin and
  • I-Ching Chou

21 April 2025

Objective: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children, characterized by inattention, hyperactivity, and impulsive behavior. In recent years, studies have shown that patients with ADHD often exp...

  • Review
  • Open Access
1,656 Views
35 Pages

Primary Hyperparathyroidism: An Analysis Amid the Co-Occurrence of Type 2 Diabetes Mellitus

  • Ana-Maria Gheorghe,
  • Mihaela Stanciu,
  • Claudiu Nistor,
  • Ioana Codruta Lebada and
  • Mara Carsote

21 April 2025

Background: Apart from classical elements in primary hyperparathyroidism (PHPT), non-classical complications, including type 2 diabetes mellitus (T2DM), are reported in some patients, but currently, they do not represent a parathyroidectomy (PTx) ind...

  • Article
  • Open Access
1,158 Views
23 Pages

Critical Management of Septic Orthopedic Patients: The Impact of Intensive Care on Survival and Recovery

  • Angelica Bratu,
  • Catalin Cirstoiu,
  • Mihnea Ioan Gabriel Popa,
  • Mihai Popescu,
  • Oana Clementina Dumitrascu,
  • Mihaela Agapie and
  • Carmen Orban

21 April 2025

The management of septic orthopedic patients, particularly those with periprosthetic joint infections (PJIs) and trauma-related sepsis, remains a significant clinical challenge. This retrospective cohort study evaluated 27 patients admitted to the In...

  • Review
  • Open Access
2,180 Views
18 Pages

Exploring the Relationship Between Obstructive Sleep Apnea and Olfactory Function

  • Antonino Maniaci,
  • Mario Lentini,
  • Maria Rita Bianco,
  • Daniele Salvatore Paternò,
  • Salvatore Lavalle,
  • Annalisa Pace,
  • Giannicola Iannella,
  • Paolo Boscolo-Rizzo,
  • Miguel Mayo-Yanez and
  • Christian Calvo-Henriquez
  • + 2 authors

21 April 2025

Obstructive sleep apnea (OSA) is increasingly recognized as a chronic condition that is closely interrelated to olfactory disorders, with a significant contribution to quality of health and overall quality of life. This narrative review aims to provi...

  • Article
  • Open Access
2 Citations
1,799 Views
13 Pages

Prevalence and Prognostic Significance of Chloride Levels in Patients with Acute Medical Conditions: A Prospective Observational Study

  • Rhita Bennis Nechba,
  • Jihane Belayachi,
  • Mina Agrou,
  • Elmostapha El Fahime,
  • Nawal Meknassi,
  • Maha Louriz,
  • Naoufel Madani and
  • Redouane Abouqal

21 April 2025

Chloride plays a considerable role in physiology. This study aimed to assess the association between serum chloride and prognosis in the population of adults with acute medical conditions. A prospective cohort study was conducted in an acute medical...

  • Review
  • Open Access
1 Citations
1,486 Views
18 Pages

Malignant Mesenchymal Tumors of the Breast: Current Challenges and New Perspectives on Primary Sarcomas and Malignant Phyllodes Tumors

  • Flavia De Lauretis,
  • Alejandro Martin Sanchez,
  • Cristina Accetta,
  • Beatrice Carnassale,
  • Sabatino D’Archi,
  • Alba Di Leone,
  • Antonio Franco,
  • Federica Gagliardi,
  • Stefano Magno and
  • Elena Jane Mason
  • + 17 authors

20 April 2025

Mesenchymal tumors of the breast constitute a rare and heterogeneous group of neoplasms, representing only 0.5% to 1% of all breast tumors. Originating from mesenchymal tissues, these tumors include various histological subtypes. They are particularl...

  • Article
  • Open Access
1 Citations
1,746 Views
14 Pages

Immune Escape and Drug Resistance Mutations in Patients with Hepatitis B Virus Infection: Clinical and Epidemiological Implications

  • Maria Antonia De Francesco,
  • Franco Gargiulo,
  • Francesca Dello Iaco,
  • Laert Zeneli,
  • Serena Zaltron,
  • Giorgio Tiecco,
  • Simone Pellizzeri,
  • Emanuele Focà,
  • Arnaldo Caruso and
  • Eugenia Quiros-Roldan

20 April 2025

Hepatitis B virus (HBV) genetic variability, shaped by high mutation rates and selective pressures, complicates its management and increases the emergence of drug-resistant and immune-escape variants. This study aims to analyze immune escape mutation...

  • Article
  • Open Access
1,219 Views
32 Pages

Nanometric and Hydrophobic Green Rust Minerals upon Exposure to Amino Acids and Nickel as Prerequisites for a Primitive Chemiosmosis

  • Nil Gaudu,
  • Chloé Truong,
  • Orion Farr,
  • Adriana Clouet,
  • Olivier Grauby,
  • Daniel Ferry,
  • Philippe Parent,
  • Carine Laffon,
  • Georges Ona-Nguema and
  • François Guyot
  • + 2 authors

19 April 2025

Geological structures known as alkaline hydrothermal vents (AHVs) likely displayed dynamic energy characteristics analogous to cellular chemiosmosis and contained iron-oxyhydroxide green rusts in the early Earth. Under specific conditions, those mine...

  • Article
  • Open Access
1 Citations
1,452 Views
24 Pages

Investigating the Effect of Algal Inclusions in Broiler Chickens

  • Hanan Al-Khalaifah,
  • Afaf Al-Nasser and
  • Tahani Al-Surrayai

17 April 2025

There is growing interest in adding marine algae to poultry feed rations. The aim of the present study is to examine the effect of various inclusions of Sargassum sp., Gracilaria sp., and Spirulina sp. on productive performance, serum proteins, liver...

  • Article
  • Open Access
787 Views
14 Pages

17 April 2025

The role of WRKY transcription factor proteins in plant defense reactions against fungal and bacterial pathogens is well studied, but less information is available about plant–virus interactions. We observed the rapid and strong activation of t...

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Life - ISSN 2075-1729