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Life, Volume 13, Issue 7

July 2023 - 196 articles

Cover Story: Although immunotherapy has proved to be a very efficient therapeutic strategy for many types of tumors, the results for pancreatic cancer (PC) have been very poor. Indeed, chemotherapy remains the standard treatment for this tumor in the advanced stage. The main reasons for the poor efficacy of immunotherapy probably lie in the peculiar features of the pancreatic tumor microenvironment in comparison with other malignancies. In addition, the biomarkers usually evaluated to define immunotherapy efficacy in other cancers appear to be useless in PC. This review aims to describe the main features of the pancreatic tumor microenvironment from an immunological point of view and to summarize the current data on immunotherapy efficacy and immune biomarkers in PC. View this paper
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Articles (196)

  • Article
  • Open Access
5 Citations
4,031 Views
20 Pages

Leaf Morphological and Epidermal Traits Variability along Environmental Gradients in Ten Natural Populations of Pistacia lentiscus

  • Abdelghafour Doghbage,
  • Safia Belhadj,
  • Fathi Abdellatif Belhouadjeb,
  • Hassen Boukerker,
  • Jean Philippe Mevy,
  • Thierry Gauquelin,
  • Alain Tonetto,
  • Saifi Merdas,
  • Bakria Touati and
  • Walid Soufan
  • + 3 authors

24 July 2023

The species belonging to the genus Pistacia possess ecological, economic, and medicinal value. They show a very high ecological plasticity. This research is a contribution to the study of the intraspecific diversity and variability of 10 populations...

  • Review
  • Open Access
10 Citations
5,790 Views
12 Pages

24 July 2023

This review article discusses the clinical significance of intraoperative neurophysiological monitoring (IONM), provides recommendations for monitoring protocols, and considers the interpretation of results in microvascular decompression (MVD) for he...

  • Article
  • Open Access
2 Citations
3,789 Views
10 Pages

Bacterial Contamination in Total Joint Replacement: Should We Change into a New Set of Clean Scrub Suits Whenever Entering the Operating Room?

  • Toshiyuki Tateiwa,
  • Yasuhito Takahashi,
  • Tsunehito Ishida,
  • Toshinori Masaoka,
  • Takaaki Shishido and
  • Kengo Yamamoto

24 July 2023

Background: The aims of this study are as follows: (1) to investigate the level and probability of bacterial contamination on scrub suits over time for medical personnel working inside and/or outside the operating room (OR) area; (2) to discuss the p...

  • Review
  • Open Access
4 Citations
3,629 Views
13 Pages

Cerebral Vasomotor Reactivity in COVID-19: A Narrative Review

  • Zahra Ghotbi,
  • Mehrdad Estakhr,
  • Melika Hosseini and
  • Reza Bavarsad Shahripour

24 July 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Among COVID-19 patients, the endothelium is considered the Achilles heel. A variety of endothelial...

  • Review
  • Open Access
3 Citations
2,977 Views
18 Pages

24 July 2023

Most human proteins are modified by enzymes that act on the α-amino group of a newly synthesized polypeptide. Methionine aminopeptidases can remove the initiator methionine and expose the second amino acid for further modification by enzymes responsi...

  • Article
  • Open Access
1 Citations
2,150 Views
11 Pages

Hemostatic Effects of Raloxifene in Ovariectomized Rats

  • Denys Alva-Chavarría,
  • Maribel Soto-Núñez,
  • Edgar Flores-Soto and
  • Ruth Jaimez

23 July 2023

This study aimed to explore the effects of raloxifene (Rx) and estradiol (E2) on prothrombin time (PT), partial thromboplastin time (APTT), coagulation factors (VII, X, XI), and fibrinogen concentrations in rats. Female rats were ovariectomized 11 da...

  • Article
  • Open Access
12 Citations
4,489 Views
14 Pages

Antiviral Potential of Specially Selected Bulgarian Propolis Extracts: In Vitro Activity against Structurally Different Viruses

  • Neli Milenova Vilhelmova-Ilieva,
  • Ivanka Nikolova Nikolova,
  • Nadya Yordanova Nikolova,
  • Zdravka Dimitrova Petrova,
  • Madlena Stephanova Trepechova,
  • Dora Ilieva Holechek,
  • Mina Mihaylova Todorova,
  • Mariyana Georgieva Topuzova,
  • Ivan Georgiev Ivanov and
  • Yulian Dimitrov Tumbarski

23 July 2023

Propolis is a natural mixture of resins, wax, and pollen from plant buds and flowers, enriched with enzymes and bee saliva. It also contains various essential oils, vitamins, mineral salts, trace elements, hormones, and ferments. It has been found th...

  • Article
  • Open Access
3 Citations
2,268 Views
12 Pages

Hypofractionated Post-Prostatectomy Radiotherapy in 16 Fractions: A Single-Institution Outcome

  • Pavol Dubinsky,
  • Vladimir Vojtek,
  • Katarina Belanova,
  • Natalia Janickova,
  • Noemi Balazova and
  • Zuzana Tomkova

23 July 2023

Background: The optimal hypofractionated schedule of post-prostatectomy radiotherapy remains to be established. We evaluated treatment outcomes and toxicity of moderately hypofractionated post-prostatectomy radiotherapy in 16 daily fractions delivere...

  • Article
  • Open Access
3 Citations
3,372 Views
17 Pages

Histopathological Pulmonary Lesions in 1st-Day Newborn Piglets Derived from PRRSV-1 MLV Vaccinated Sows at the Last Stage of Gestation

  • Georgios I. Papakonstantinou,
  • Dimitra Psalla,
  • Aris Pourlis,
  • Ioanna Stylianaki,
  • Labrini V. Athanasiou,
  • Eleni Tzika,
  • Eleftherios Meletis,
  • Polychronis Kostoulas,
  • George Maragkakis and
  • Vasileios G. Papatsiros
  • + 1 author

23 July 2023

Modified live virus (MLV) vaccines for the control of porcine respiratory and reproductive syndrome virus (PRRSV) have been associated with the vertical and horizontal transmission of vaccine viruses. The present study aimed to describe pathological...

  • Review
  • Open Access
7 Citations
3,124 Views
12 Pages

22 July 2023

Metabolic syndrome (MetS) imposes a substantial burden on the healthcare systems and economies of countries and is a major public health concern worldwide. MetS is mainly caused by an imbalance between calorie intake and energy expenditure; however,...

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Life - ISSN 2075-1729