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Life, Volume 13, Issue 7

July 2023 - 196 articles

Cover Story: Although immunotherapy has proved to be a very efficient therapeutic strategy for many types of tumors, the results for pancreatic cancer (PC) have been very poor. Indeed, chemotherapy remains the standard treatment for this tumor in the advanced stage. The main reasons for the poor efficacy of immunotherapy probably lie in the peculiar features of the pancreatic tumor microenvironment in comparison with other malignancies. In addition, the biomarkers usually evaluated to define immunotherapy efficacy in other cancers appear to be useless in PC. This review aims to describe the main features of the pancreatic tumor microenvironment from an immunological point of view and to summarize the current data on immunotherapy efficacy and immune biomarkers in PC. View this paper
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Articles (196)

  • Article
  • Open Access
4 Citations
2,602 Views
12 Pages

Suppression of Metastatic Ovarian Cancer Cells by Bepridil, a Calcium Channel Blocker

  • Songzi Zhang,
  • Dokyeong Kim,
  • Minyoung Park,
  • Jing Hu Yin,
  • Junseong Park and
  • Yeun-Jun Chung

22 July 2023

Although surgery followed by platinum-based therapy is effective as a standard treatment in the early stages of ovarian cancer, the majority of cases are diagnosed at advanced stages, leading to poor prognosis. Thus, the identification of novel thera...

  • Article
  • Open Access
1 Citations
4,678 Views
11 Pages

21 July 2023

Background: The passive leg-raising (PLR) test was developed to predict fluid responsiveness and reduce fluid overload. However, the hemodynamic response of healthy individuals to the PLR test and how it changes during the day, between the morning an...

  • Review
  • Open Access
4 Citations
2,880 Views
13 Pages

21 July 2023

Due to technological advancements during the past 20 years, transcatheter aortic valve replacements (TAVRs) have significantly improved the treatment of symptomatic and severe aortic stenosis, significantly improving patient outcomes. The continuous...

  • Article
  • Open Access
8 Citations
2,212 Views
20 Pages

21 July 2023

Plants with high biomass adapted to conditions of increased moisture and with significant salt tolerance appear to be particularly attractive candidates for phytoremediation studies. The aim of the present study was to examine the tolerance of Rumex...

  • Review
  • Open Access
10 Citations
5,589 Views
18 Pages

Lung Transplantation in a New Era in the Field of Cystic Fibrosis

  • Wei Huang,
  • Alexander T. Smith,
  • Maksim Korotun,
  • Aldo Iacono and
  • Janice Wang

21 July 2023

Lung transplantation for people with cystic fibrosis (PwCF) is a critical therapeutic option, in a disease without a cure to this day, and its overall success in this population is evident. The medical advancements in knowledge, treatment, and clinic...

  • Article
  • Open Access
4 Citations
2,672 Views
13 Pages

Decreased HDL-C Levels as a Predictor of Organ Failure in Acute Pancreatitis in the Emergency Department

  • Ana Rocío Venegas-Tamayo,
  • Olga Mariel Peña-Veites,
  • Martha Alicia Hernández-González and
  • Cornelio Barrientos-Alvarado

21 July 2023

High-density lipoprotein cholesterol (HDL-C) is reported as a biomarker of systemic inflammation and multi-organ failure (MOF), which has been rarely investigated in acute pancreatitis (AP), a frequent condition in the emergency department (ED). The...

  • Review
  • Open Access
4 Citations
3,332 Views
11 Pages

Golimumab for Polyarticular Juvenile Idiopathic Arthritis and Psoriatic Arthritis: Pharmacologic and Clinical Considerations

  • Sydney Moore McIntosh,
  • Christian Kerut,
  • Payton P. Hollenshead,
  • Dorothy H. Askins,
  • Kasra Mansourian,
  • Zachary R. Palowsky,
  • Varsha Allampalli,
  • Shahab Ahmadzadeh,
  • Sahar Shekoohi and
  • Alan D. Kaye

21 July 2023

Psoriatic arthritis is a chronic debilitating autoimmune condition, and when diagnosed in patients before the age of eighteen, it is considered pediatric polyarticular juvenile idiopathic arthritis. Monoarticular or polyarticular psoriatic arthritis...

  • Article
  • Open Access
3 Citations
2,566 Views
24 Pages

21 July 2023

Breast cancer continuously poses serious clinical challenges to human health due to its intrinsic heterogenicity and evolving drug resistance. Recently, increasing evidence has shown that pyroptosis, known as a programmed and inflammatory form of cel...

  • Review
  • Open Access
27 Citations
5,703 Views
16 Pages

The Role of Renin–Angiotensin System in Diabetic Cardiomyopathy: A Narrative Review

  • João Pedro Thimotheo Batista,
  • André Oliveira Vilela de Faria,
  • Thomas Felipe Silva Ribeiro and
  • Ana Cristina Simões e Silva

21 July 2023

Diabetic cardiomyopathy refers to myocardial dysfunction in type 2 diabetes, but without the traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease. The activation of the renin–angiotensin system (RAS), o...

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Life - ISSN 2075-1729