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Genes, Volume 9, Issue 12

December 2018 - 79 articles

Cover Story: The genome of the grizzly bear Samson was sequenced at BC Cancer’s Michael Smith Genome Sciences Centre. Orphaned in the wilds of Alaska 20 years ago, Samsom resides at the Toronto Zoo and his genome will now further research to better understand his species. This genome was the first to be published as part of the CanSeq150 project, which was launched to gain insight into our environment and to commemorate the 150th Birthday of Canada. This assembly is the most contiguous representative of the Ursus genus, benefiting from both microfluidic partitioning library construction and nanopore long read sequencing. View this paper.
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Articles (79)

  • Article
  • Open Access
43 Citations
5,111 Views
15 Pages

Fitness Costs of the Glutathione S-Transferase Epsilon 2 (L119F-GSTe2) Mediated Metabolic Resistance to Insecticides in the Major African Malaria Vector Anopheles Funestus

  • Magellan Tchouakui,
  • Jacob M. Riveron,
  • Doumani Djonabaye,
  • Williams Tchapga,
  • Helen Irving,
  • Patrice Soh Takam,
  • Flobert Njiokou and
  • Charles S. Wondji

19 December 2018

Metabolic resistance to insecticides threatens malaria control. However, little is known about its fitness cost in field populations of malaria vectors, thus limiting the design of suitable resistance management strategies. Here, we assessed the asso...

  • Article
  • Open Access
58 Citations
9,762 Views
20 Pages

Fragmented Nuclear DNA Is the Predominant Genetic Material in Human Hair Shafts

  • Michael D. Brandhagen,
  • Odile Loreille and
  • Jodi A. Irwin

18 December 2018

While shed hairs are one of the most commonly encountered evidence types, they are among the most limited in terms of DNA quantity and quality. As a result, nuclear DNA short tandem repeat (STR) profiling is generally unsuccessful and DNA testing of...

  • Article
  • Open Access
35 Citations
7,405 Views
15 Pages

Blood-Based Biomarkers for Predicting the Risk for Five-Year Incident Coronary Heart Disease in the Framingham Heart Study via Machine Learning

  • Meeshanthini V. Dogan,
  • Steven R. H. Beach,
  • Ronald L. Simons,
  • Amaury Lendasse,
  • Brandan Penaluna and
  • Robert A. Philibert

18 December 2018

An improved approach for predicting the risk for incident coronary heart disease (CHD) could lead to substantial improvements in cardiovascular health. Previously, we have shown that genetic and epigenetic loci could predict CHD status more sensitive...

  • Review
  • Open Access
50 Citations
9,055 Views
14 Pages

18 December 2018

Ribose 2′-O-methylation is certainly one of the most common RNA modifications found in almost any type of cellular RNA. It decorates transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), small nuclear RNAs (snRNAs) (and most probably small nucleolar R...

  • Article
  • Open Access
48 Citations
5,585 Views
9 Pages

Exploring the Variable Phenotypes of RPGR Carrier Females in Assessing Their Potential for Retinal Gene Therapy

  • Anika Nanda,
  • Anna P. Salvetti,
  • Penny Clouston,
  • Susan M. Downes and
  • Robert E. MacLaren

18 December 2018

Inherited retinal degenerations are the leading cause of blindness in the working population. X-linked retinitis pigmentosa (XLRP), caused by mutations in the Retinitis pigmentosa GTPase regulator (RPGR) gene is one of the more severe forms, and fema...

  • Article
  • Open Access
9 Citations
5,910 Views
16 Pages

MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets

  • Tania Singh,
  • Luis Sarmiento,
  • Cheng Luan,
  • Rashmi B. Prasad,
  • Jenny Johansson,
  • Luis R. Cataldo,
  • Erik Renström,
  • Shamit Soneji,
  • Corrado Cilio and
  • Isabella Artner

18 December 2018

Type 1 (T1D) and type 2 (T2D) diabetes are triggered by a combination of environmental and/or genetic factors. Maf transcription factors regulate pancreatic beta (β)-cell function, and have also been implicated in the regulation of immunomodulat...

  • Article
  • Open Access
40 Citations
6,669 Views
13 Pages

Genome Based Meta-QTL Analysis of Grain Weight in Tetraploid Wheat Identifies Rare Alleles of GRF4 Associated with Larger Grains

  • Raz Avni,
  • Leah Oren,
  • Gai Shabtay,
  • Siwar Assili,
  • Curtis Pozniak,
  • Iago Hale,
  • Roi Ben-David,
  • Zvi Peleg and
  • Assaf Distelfeld

17 December 2018

The domestication and subsequent genetic improvement of wheat led to the development of large-seeded cultivated wheat species relative to their smaller-seeded wild progenitors. While increased grain weight (GW) continues to be an important goal of ma...

  • Article
  • Open Access
22 Citations
5,341 Views
12 Pages

17 December 2018

Genus Epimedium consists of approximately 50 species in China, and more than half of them possess medicinal properties. The high similarity of species’ morphological characteristics complicates the identification accuracy, leading to potential...

  • Article
  • Open Access
8 Citations
4,632 Views
12 Pages

17 December 2018

Auxin is a major hormone which plays crucial roles in instructing virtually all developmental programs of plants. Its signaling depends primarily on its perception by four partially redundant receptors of the TIR1/AFB2 clade (TAARs), which subsequent...

  • Article
  • Open Access
24 Citations
4,751 Views
22 Pages

De Novo Analysis Reveals Transcriptomic Responses in Eriobotrya japonica Fruits during Postharvest Cold Storage

  • Shoukai Lin,
  • Ti Wu,
  • Hailan Lin,
  • Yanqing Zhang,
  • Shichang Xu,
  • Jinge Wang,
  • Bisha Wu,
  • Yu Chen,
  • Suying Lin and
  • Dahe Lin
  • + 3 authors

17 December 2018

Cold storage is the primary preservation method of postharvest loquat fruits. However, cold storage also results in many chilling injury physiological disorders called lignification, which decreases the quality and economic value of the fruits. Few s...

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Genes - ISSN 2073-4425