Special Issue "Chromosome Replication and Genome Integrity"
Deadline for manuscript submissions: closed (31 October 2018) | Viewed by 99261
Genome replication is central for cellular proliferation and is critically implicated in several human diseases. Various factors associate with the replication fork, stably or transiently, to promote replication, globally or at specific genomic regions, such as telomeres and centromeres, and at genomic locations containing DNA lesions, structured DNA, repetitive segments, and heterochromatin. Some of the DNA metabolism reactions associated with genomic replication facilitate DNA synthesis and replication restart, activate or dampen DNA damage response pathways coordinating repair and/or the origin usage program, resolve topological intermediates arising from recombination or transcription-replication clashes, establish or disrupt chromatin modifications and chromosome structure. Deficiencies in these individual pathways associated with chromosome replication cause various human genetic disorders, or predispose to cancer and progeria. This Special Issue in Genes on “Chromosome Replication and Genome Integrity” will address the mechanisms through which processes responding to adverse genome perturbations occur, providing an overview of recent developments in specialized research topics and critical perspectives on upcoming challenges.
Dr. Dana Branzei
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Chromosome replication
- DNA damage tolerance and repair
- Fragile genomic regions
- Chromatin and chromosome structure
- DNA damage response