Beyond Transcription: Fine-Tuning of Circadian Timekeeping by Post-Transcriptional Regulation
by
Julieta Lisa Mateos 1,*
, Maria José De Leone 1, Jeanette Torchio 1, Marlene Reichel 2 and Dorothee Staiger 2,*
Julieta Lisa Mateos 1,*, Maria José De Leone 1, Jeanette Torchio 1, Marlene Reichel 2 and Dorothee Staiger 2,*
1
Fundación Instituto Leloir, Av. Patricias Argentinas, Buenos Aires C1405BWE, Argentina
2
RNA Biology and Molecular Physiology, Faculty for Biology, Bielefeld University, Universitaetsstrasse 25, D-33615 Bielefeld, Germany
*
Authors to whom correspondence should be addressed.
Genes 2018, 9(12), 616; https://doi.org/10.3390/genes9120616
Received: 6 November 2018 / Revised: 29 November 2018 / Accepted: 3 December 2018 / Published: 10 December 2018
(This article belongs to the Special Issue Genetic Regulation of Circadian Rhythm in Plants)
The circadian clock is an important endogenous timekeeper, helping plants to prepare for the periodic changes of light and darkness in their environment. The clockwork of this molecular timer is made up of clock proteins that regulate transcription of their own genes with a 24 h rhythm. Furthermore, the rhythmically expressed clock proteins regulate time-of-day dependent transcription of downstream genes, causing messenger RNA (mRNA) oscillations of a large part of the transcriptome. On top of the transcriptional regulation by the clock, circadian rhythms in mRNAs rely in large parts on post-transcriptional regulation, including alternative pre-mRNA splicing, mRNA degradation, and translational control. Here, we present recent insights into the contribution of post-transcriptional regulation to core clock function and to regulation of circadian gene expression in Arabidopsis thaliana.
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Keywords:
circadian; post-transcriptional; RNA; splicing; RNA-binding proteins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Mateos, J.L.; De Leone, M.J.; Torchio, J.; Reichel, M.; Staiger, D. Beyond Transcription: Fine-Tuning of Circadian Timekeeping by Post-Transcriptional Regulation. Genes 2018, 9, 616.
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