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Genes 2018, 9(12), 617;

Mechanisms of DNA Methyltransferase Recruitment in Mammals

Epigenetics and Cell Fate, UMR7216 CNRS, University Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France
New England Biolabs, 240 County Rd, Ipswich, MA 01938, USA
Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 30 November 2018 / Accepted: 5 December 2018 / Published: 10 December 2018
(This article belongs to the Special Issue Role of DNA Methyltransferases in the Epigenome)
PDF [1557 KB, uploaded 10 December 2018]


DNA methylation is an essential epigenetic mark in mammals. The proper distribution of this mark depends on accurate deposition and maintenance mechanisms, and underpins its functional role. This, in turn, depends on the precise recruitment and activation of de novo and maintenance DNA methyltransferases (DNMTs). In this review, we discuss mechanisms of recruitment of DNMTs by transcription factors and chromatin modifiers—and by RNA—and place these mechanisms in the context of biologically meaningful epigenetic events. We present hypotheses and speculations for future research, and underline the fundamental and practical benefits of better understanding the mechanisms that govern the recruitment of DNMTs. View Full-Text
Keywords: epigenetics; DNA methylation; DNA methyltransferases epigenetics; DNA methylation; DNA methyltransferases

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Laisné, M.; Gupta, N.; Kirsh, O.; Pradhan, S.; Defossez, P.-A. Mechanisms of DNA Methyltransferase Recruitment in Mammals. Genes 2018, 9, 617.

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