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Genes 2018, 9(12), 622; https://doi.org/10.3390/genes9120622

Chromatin as a Platform for Modulating the Replication Stress Response

1
Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada
2
Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 1L3, Canada
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Received: 30 October 2018 / Revised: 3 December 2018 / Accepted: 4 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)
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Abstract

Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances in our understanding of histone supply, histone recycling and nascent histone incorporation during replication. Furthermore, much is now known about the roles of histone remodellers and post-translational modifications in replication. It has also become clear that nucleosome dynamics during replication play critical roles in genome maintenance and that chromatin modifiers are important for preventing DNA replication stress. An understanding of how cells deploy specific nucleosome modifiers, chaperones and remodellers directly at sites of replication fork stalling has been building more slowly. Here we will specifically discuss recent advances in understanding how chromatin composition contribute to replication fork stability and restart. View Full-Text
Keywords: chromatin; replication stress; histone chaperone; chromatin remodeller; genome instability chromatin; replication stress; histone chaperone; chromatin remodeller; genome instability
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Fournier, L.-A.; Kumar, A.; Stirling, P.C. Chromatin as a Platform for Modulating the Replication Stress Response. Genes 2018, 9, 622.

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