Special Issue "Genetic Epidemiology of Complex Diseases in Latin America"
Deadline for manuscript submissions: closed (1 November 2018)
Dr. Carolina Bonilla
Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, Brazil
Interests: genetic epidemiology, mendelian randomization, cancer, pigmentation, admixture, population genetics, mitochondrial DNA, Latin America
The identification of genetic risk factors for complex diseases has been carried out for the most part in populations of European ancestry, and whilst this has been an important and exciting advance in the field of genetic epidemiology, there is much more to be done in terms of globally understanding the risk of disease. Uncovering and characterising complex disease loci in diverse populations is paramount for revealing underlying biological mechanisms and for the future development of risk prediction models in non-European populations.
Latin American populations exhibit vast genetic and phenotypic diversity due in part to their history of admixture between indigenous populations, Europeans and West Africans during the conquest and colonisation of the American continent, as well as to their adaptation to a range of different environments. Subsequent migratory waves have added to this already diverse background. Although a few genome-wide association studies (GWAS) have included Hispanic/Latinos, as per the US Census Bureau definition, the diversity within this—somewhat artificial—grouping deserves to be examined more closely if we are keen to address population health inequalities.
In this special issue we would like to provide an overview of the state of the art of genetic epidemiology research on complex diseases in Latin American populations. We welcome studies of any design (e.g., GWAS, candidate gene, case-control, cohort, meta-analysis, Mendelian randomization) that have been performed on any complex disease in a Latin American population. We look forward to your contributions.
Dr. Carolina Bonilla
Manuscript Submission Information
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- Complex diseases
- Latin America
- Risk factor
- Mendelian randomization
- Genome-wide association study