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Genes, Volume 13, Issue 12

December 2022 - 241 articles

Cover Story: Clostridioides difficile is an obligate anaerobic pathogen that is among the most common causes of healthcare-associated infections. It poses a global threat due to the clinical outcomes of infection and resistance to antibiotics recommended by international guidelines for its eradication. In particular, C. difficile infection can lead to fulminant colitis associated with shock, hypotension, megacolon, and, in severe cases, death. It is therefore of the utmost urgency to fully characterize this pathogen and to better understand its spread, in order to reduce infection rates and improve therapy success. Our work focuses on the genetic evolution of C. difficile virulence, antimicrobial resistance, the molecular typing techniques used to characterize this pathogen, the global distribution of the most common ribotypes, and novel genetic engineering strategies to control this threat. View this paper
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Articles (241)

  • Article
  • Open Access
13 Citations
3,729 Views
11 Pages

19 December 2022

Recent studies have suggested an association between obesity and dyslipidemia in the development of type 2 diabetes (T2D). The purpose of this study was to explore the causal effects of obesity and dyslipidemia on T2D risk in Asians. Two-sample Mende...

  • Article
  • Open Access
3 Citations
2,319 Views
16 Pages

19 December 2022

Feed efficiency (FE) is a very important trait affecting the economic benefits of pig breeding enterprises. Adipose tissue can modulate a variety of processes such as feed intake, energy metabolism and systemic physiological processes. However, the m...

  • Article
  • Open Access
10 Citations
3,043 Views
10 Pages

Analysis of Copy Number Variation in the Whole Genome of Normal-Haired and Long-Haired Tianzhu White Yaks

  • Guangyao Meng,
  • Qi Bao,
  • Xiaoming Ma,
  • Min Chu,
  • Chun Huang,
  • Xian Guo,
  • Chunnian Liang and
  • Ping Yan

18 December 2022

Long-haired individuals in the Tianzhu white yak population are a unique genetic resource, and have important landscape value. Copy number variation (CNV) is an important source of phenotypic variation in mammals. In this study, we used resequencing...

  • Article
  • Open Access
6 Citations
2,526 Views
19 Pages

18 December 2022

Pyracantha fortuneana (Maxim.) Li (Rosaceae), commonly known as Chinese firethorn, is an evergreen shrub with high nutritional, medicinal, and horticultural importance. This species typically has white flowers, but a rare red flower phenotype has bee...

  • Article
  • Open Access
3 Citations
2,259 Views
13 Pages

MDSN: A Module Detection Method for Identifying High-Order Epistatic Interactions

  • Yan Sun,
  • Yijun Gu,
  • Qianqian Ren,
  • Yiting Li,
  • Junliang Shang,
  • Jin-Xing Liu and
  • Boxin Guan

18 December 2022

Epistatic interactions are referred to as SNPs (single nucleotide polymorphisms) that affect disease development and trait expression nonlinearly, and hence identifying epistatic interactions plays a great role in explaining the pathogenesis and gene...

  • Article
  • Open Access
4 Citations
2,943 Views
16 Pages

18 December 2022

Machilus chuanchienensis is an ecological tree distributed in southwestern China. It has a significant valuation with making Hawk tea using its leaves, an ethnic traditional tea-like beverage with a long history in Chinese tea culture. The whole chlo...

  • Article
  • Open Access
1 Citations
2,140 Views
7 Pages

Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma

  • Vladimír Vašků,
  • Jan Máchal,
  • Filip Zlámal and
  • Anna Vašků

18 December 2022

Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Departme...

  • Article
  • Open Access
20 Citations
3,404 Views
17 Pages

Revealing the Potential Markers of N(4)-Acetylcytidine through acRIP-seq in Triple-Negative Breast Cancer

  • Xingda Zhang,
  • Jiaqi Zeng,
  • Jianyu Wang,
  • Zihan Yang,
  • Song Gao,
  • Honghao Liu,
  • Guozheng Li,
  • Xin Zhang,
  • Yue Gu and
  • Da Pang

18 December 2022

Understanding the causes of tumorigenesis and progression in triple-receptor negative breast cancer (TNBC) can help the design of novel and personalized therapies and prognostic assessments. Abnormal RNA modification is a recently discovered process...

  • Article
  • Open Access
14 Citations
3,888 Views
14 Pages

Fragile X-Associated Neuropsychiatric Disorders (FXAND) in Young Fragile X Premutation Carriers

  • Ramkumar Aishworiya,
  • Dragana Protic,
  • Si Jie Tang,
  • Andrea Schneider,
  • Flora Tassone and
  • Randi Hagerman

17 December 2022

Background: The fragile X premutation carrier state (PM) (55–200 CGG repeats in the fragile X messenger ribonucleoprotein 1, FMR1 gene) is associated with several conditions, including fragile X-associated primary ovarian insufficiency (FXPOI)...

  • Communication
  • Open Access
5 Citations
2,480 Views
12 Pages

Cloning and Functional Characterization of SpZIP2

  • Tian-Long Han,
  • Ting-Wei Tang,
  • Pei-Hong Zhang,
  • Min Liu,
  • Jing Zhao,
  • Jia-Shi Peng and
  • Shuan Meng

17 December 2022

Zinc (Zn)-regulated and iron (Fe)-regulated transporter-like proteins (ZIP) are key players involved in the accumulation of cadmium (Cd) and Zn in plants. Sedum plumbizincicola X.H. Guo et S.B. Zhou ex L.H. Wu (S. plumbizincicola) is a Crassulaceae C...

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Genes - ISSN 2073-4425