Dynamics of DNA Double Strand Breaks
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 July 2022) | Viewed by 28745
Special Issue Editor
Special Issue Information
Dear Colleagues,
A DNA double-strand break (DSB) is one of the most toxic lesions for a cell. Repair systems exist that aim at maintaining genomic integrity, including non-homologous end joining (NHEJ) and homologous recombination (HR). NHEJ roughly and quickly ligates two DNA double-strand ends. HR is a more sophisticated pathway that searches a homologous partner in the genome and uses it as a template to restore the original sequence. NHEJ and HR guarantee the integrity of the genome, but are also generators of genomic instability: both can lead to rearrangements eventually associated to mutagenesis at the junction. Among other risks, finding the right partner is crucial. NHEJ between originally distant DNA ends leads to deletions, inversions, or translocations. HR between repeated sequences generates rearrangements. Avoiding these events is a keystone in the preservation of genomic integrity. In addition to HR and NHEJ, other DSB repair pathways exist that are necessarily mutagenic. They mostly rely on the use of microhomologies, which is quite a risky way to repair DSBs. Their outcomes are deletions and/or translocations, sometimes coupled to insertions. These pathways must be “last-resort” options, used when DSBs cannot be repaired by the more conservative HR and NHEJ.
Thus, the choices of the right pathway and the right partner are pivotal and are regulated by multiple safeguards, including the cell cycle phase, the chromatin context, and the nuclear compartment. In this Special Issue we propose to discuss how DSBs are transmitted along the cell cycle to be repaired in the appropriate phase. We will also examine where and how DSBs move in the nuclear compartment and how the chromatin context influences the outcome of the repair.
Dr. Josee Guirouilh-Barbat
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA double-strand breaks
- DSB dynamics
- Nuclear organization
- DNA damage response
- Chromatin
- DSB repair pathway choice
- Homologous recombination
- Non-homologous end joining
- Cell cycle phase
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.