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Cells, Volume 14, Issue 6

March-2 2025 - 79 articles

Cover Story: Two Drosophila antimicrobial peptides (AMPs), Cecropin A and Drosocin, are induced in the body fat of multiple sex combs (mxc) mutant larvae with tumors in hematopoietic tissues depending on the Toll- and Imd-mediated innate immune pathways. Overexpression of the AMPs suppressed tumor growth via apoptosis induction in the mutant but not in normal tissues, indicating anti-tumor properties. The injection of synthetic Cecropin also induced apoptosis in the tumors. The AMPs were incorporated into the macrophage-like cells in mutant but not normal larvae. Another AMP, Drosomycin, was taken up via phagocytosis factors, Draper and Shark. Enhanced phosphatidylserine signals were observed on the tumor surface. Inhibition of the exposed signals enhanced tumor growth. AMPs may target the signals to induce apoptosis to execute their tumor-specific effects. View this paper
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Articles (79)

  • Review
  • Open Access
1 Citations
2,065 Views
68 Pages

Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches

  • Thea Chevalley,
  • Marion Dübi,
  • Laurent Fumeaux,
  • Maria Serena Merli,
  • Alexandre Sarre,
  • Natacha Schaer,
  • Umberto Simeoni and
  • Catherine Yzydorczyk

20 March 2025

The global incidence and prevalence of cardiometabolic disorders have risen significantly in recent years. Although lifestyle choices in adulthood play a crucial role in the development of these conditions, it is well established that events occurrin...

  • Review
  • Open Access
3 Citations
2,178 Views
32 Pages

Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma

  • Mahmoud Zhra,
  • Muhammad Affan Elahi,
  • Aamira Tariq,
  • Ahmed Abu-Zaid and
  • Ahmed Yaqinuddin

20 March 2025

Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The gut microbiome interacts with the liver via a bidirectional relations...

  • Article
  • Open Access
1 Citations
1,305 Views
30 Pages

Juglone-Bearing Thiopyrano[2,3-d]thiazoles Induce Apoptosis in Colorectal Adenocarcinoma Cells

  • Yuliia Kozak,
  • Nataliya Finiuk,
  • Robert Czarnomysy,
  • Agnieszka Gornowicz,
  • Roman Pinyazhko,
  • Andrii Lozynskyi,
  • Serhii Holota,
  • Olga Klyuchivska,
  • Andriy Karkhut and
  • Svyatoslav Polovkovych
  • + 5 authors

20 March 2025

Colorectal cancer is a major global health challenge, with current treatments limited by toxicity and resistance. Thiazole derivatives, known for their bioactivity, are emerging as promising alternatives. Juglone (5-hydroxy-1,4-naphthoquinone) is a n...

  • Article
  • Open Access
1,432 Views
14 Pages

Extracellular Vesicles from Regenerating Skeletal Muscle Mitigate Muscle Atrophy in an Amyotrophic Lateral Sclerosis Mouse Model

  • Jinghui Gao,
  • Aria Sikal,
  • Rachel Hankin,
  • Yaochao Zheng,
  • Elijah Sterling,
  • Kenny Chan and
  • Yao Yao

20 March 2025

Amyotrophic lateral sclerosis (ALS) is a devastating neuromuscular disease characterized by progressive motor neuron degeneration and muscle atrophy, with no effective treatments available. Chronic inflammation, which impairs muscle regeneration and...

  • Article
  • Open Access
8 Citations
6,214 Views
16 Pages

20 March 2025

Over the last few decades, the prevalence of metabolic diseases such as obesity, diabetes, non-alcoholic fatty liver disease, hypertension, and hyperuricemia has surged, primarily due to high-fat diet (HFD). The pathologies of these metabolic disease...

  • Review
  • Open Access
3 Citations
1,975 Views
17 Pages

20 March 2025

Chronic pain is a global health problem with major socioeconomic implications. Drug therapy for chronic pain is limited, prompting search for non-pharmacological treatments. One such approach is physical exercise, which has been found to be beneficia...

  • Article
  • Open Access
1 Citations
1,193 Views
24 Pages

Efficacy of Deferoxamine Mesylate in Serum and Serum-Free Media: Adult Ventral Root Schwann Cell Survival Following Hydrogen Peroxide-Induced Cell Death

  • Yee Hang Ethan Ma,
  • Abhinay R. Putta,
  • Cyrus H. H. Chan,
  • Stephen R. Vidman,
  • Paula Monje and
  • Giles W. Plant

20 March 2025

Schwann cell (SC) transplantation shows promise in treating spinal cord injury as a pro-regenerative agent to allow host endogenous neurons to bridge over the lesion. However, SC transplants face significant oxidative stress facilitated by ROS in the...

  • Review
  • Open Access
2,467 Views
28 Pages

Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure

  • Ivan Sherstnev,
  • Aleksandra Judina,
  • Giovanni Battista Luciani,
  • Alessandra Ghigo,
  • Emilio Hirsch and
  • Julia Gorelik

20 March 2025

Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signall...

  • Review
  • Open Access
2 Citations
2,378 Views
19 Pages

Ciliary Ion Channels in Polycystic Kidney Disease

  • Lubna A. Alshriem,
  • Raghad Buqaileh,
  • Qasim Alorjani and
  • Wissam AbouAlaiwi

19 March 2025

Polycystic kidney disease (PKD) is the most common hereditary disorder that disrupts renal function and frequently progresses to end-stage renal disease. Recent advances have elucidated the critical role of primary cilia and ciliary ion channels, inc...

  • Review
  • Open Access
4 Citations
3,145 Views
50 Pages

Colorectal Organoids: Models, Imaging, Omics, Therapy, Immunology, and Ethics

  • Martina Taglieri,
  • Linda Di Gregorio,
  • Serena Matis,
  • Chiara Rosa Maria Uras,
  • Massimo Ardy,
  • Sara Casati,
  • Monica Marchese,
  • Alessandro Poggi,
  • Lizzia Raffaghello and
  • Roberto Benelli

19 March 2025

Colorectal epithelium was the first long-term 3D organoid culture established in vitro. Identification of the key components essential for the long-term survival of the stem cell niche allowed an indefinite propagation of these cultures and the modul...

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Cells - ISSN 2073-4409Creative Common CC BY license