Genetic and Cellular Basis of Autoimmune Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 644

Special Issue Editor


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Guest Editor
Department of Dermatology, Universität zu Lübeck, Lübeck, Germany
Interests: innate immunity; granulocytes; autoimmune diseases; skin inflammation; lipid mediators; Fcγ receptors
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Special Issue Information

Dear Colleagues,

Autoimmune diseases represent a significant and growing challenge to public health, affecting millions worldwide and contributing to considerable morbidity and mortality. In recent years, advances in genomic technologies and cellular biology have transformed our understanding of the intricate mechanisms underlying these diseases. High-throughput sequencing and genome-wide association studies (GWASs) have identified numerous genetic loci associated with autoimmune conditions, shedding light on the heritable components of these disorders. Concurrently, research into cellular pathways and immune responses has unveiled the roles of various immune cell types, including T cells, B cells, and innate immune cells, such as neutrophils and macrophages, in the pathogenesis of autoimmune diseases

This Special Issue aims to consolidate current knowledge on the genetic and cellular foundations of autoimmune diseases, highlighting recent discoveries and ongoing research. We invite contributions that explore the molecular mechanisms driving autoimmunity, the impact of genetic variations on immune function, and the interactions between genetic and environmental factors. By fostering a comprehensive understanding of these complex interactions, particularly the role of effector cells like neutrophils, we hope to pave the way for innovative therapeutic strategies and improved patient outcomes. In this Special Issue, we want to bring together leading experts in the field, showcasing diverse perspectives that underscore the importance of interdisciplinary collaboration in unraveling the complexities of autoimmune diseases.

Prof. Dr. Christian Sadik
Guest Editor

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Keywords

  • autoimmune disease
  • break of tolerance
  • effector cells
  • immunodysregulation
  • risk genes

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Published Papers (1 paper)

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9 pages, 6690 KiB  
Brief Report
Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients
by Bharati Matta, Lydia Thomas, Vinay Sharma and Betsy J. Barnes
Cells 2025, 14(6), 454; https://doi.org/10.3390/cells14060454 - 19 Mar 2025
Viewed by 412
Abstract
T follicular helper (Tfh) and T follicular regulatory cells (Tfr) are required for antibody production and are dysregulated in SLE. Genetic variants within or near interferon regulatory factor 5 (IRF5) are associated with SLE risk. We previously reported higher plasma cells [...] Read more.
T follicular helper (Tfh) and T follicular regulatory cells (Tfr) are required for antibody production and are dysregulated in SLE. Genetic variants within or near interferon regulatory factor 5 (IRF5) are associated with SLE risk. We previously reported higher plasma cells and autoantibodies in healthy IRF5-SLE homozygous risk carriers. Here, we report the dysregulation of circulating Tfh and Tfr in both SLE patients and presymptomatic IRF5-SLE homozygous risk carriers. Full article
(This article belongs to the Special Issue Genetic and Cellular Basis of Autoimmune Diseases)
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