Sepsis: Pathogenesis, Pathophysiology, Molecular and Cellular Mechanisms and Immunity
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 1706
Special Issue Editors
Interests: sepsis; critical care medicine; coagulopathy; innate immunity; MODS; molecular and cellular biology
Interests: translational research into haemostatic dysfunction in critical illness; focused on understanding the cross talk between coagulation activation; inflammation; innate immunity
Special Issue Information
Dear Colleagues,
Sepsis can lead to infection-induced multiple organ dysfunction syndrome (MODS), often companied by lymphocytopenia, immunosuppression, shock, coagulopathy and disseminated intravascular coagulation (DIC). The infection initiates from the release of pathogen-associated molecule patterns (PAMPs), which activate Toll-like receptors (TLRs) and downstream pathways, and subsequently, various innate immune responses, including the emergence of cytokine storms. When progressing to the late stages, sepsis is dominated by immunosuppression and MODS, which is very similar to other critical illnesses.
Many investigations have focused on late-stage sepsis and have not allowed us to gain sufficient knowledge about the early stages of sepsis. To understand how infection induces sepsis and what are the key molecular pathways, we are pleased to announce a Special Issue of Cells, inviting authors to submit their original research, communications and review articles aiming to enhance our mechanistic understanding. We encourage contributions on a wide range of topics, including, but not limited to, the following:
- PAMPs and TLRs;
- Novel signal pathways that bridge the triggers and immune responses;
- Cell death and DAMPs;
- Mechanisms of coagulopathy;
- Mechanisms of septic shock;
- Immune cell biology, including neutrophils, macrophages, dendritic cells and lymphocytes;
- Endothelial activation and damage;
- Small non-coding RNAs and RNA splicing;
- Genome recombination and immune responses;
- Roles of toxins and complements;
- NETosis and microcirculation impairments.
Prof. Dr. Guozheng Wang
Dr. Simon Abrams
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sepsis
- bacterial infection
- PAMPs
- DAMPs
- TLRs
- small RNAs
- RNA splicing
- DNA recombination
- signaling pathways
- cell death
- NET/NETosis
- coagulopathy
- DIC
- toxins
- complements
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