Table of Contents
Crystals, Volume 6, Issue 12 (December 2016)
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Cover Story (view full-size image) BilE is important for bile resistance and colonization of the gastrointestinal tract by the [...] Read more. BilE is important for bile resistance and colonization of the gastrointestinal tract by the pathogen Listeria monocytogenes. BilE shares significant sequence similarity with well-studied ATP-binding cassette importers but no transport activity has been observed. We solved a crystal structure of the putative substrate-binding domain of BilE at 1.5 Å and found that the binding site varies considerably relative to characterized homologs. This suggests that BilE may bind an as-yet unknown ligand. Elucidation of the natural substrate could reveal a novel bile resistance mechanism. View this paper.