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Open AccessArticle

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

by Yong Du 1,*, Qiang Cai 1, Jiadan Xue 2 and Qi Zhang 1
1
Centre for THz Research, China Jiliang University, Hangzhou 310018, China
2
Department of Chemisty, Zhejiang Sci-Tech University, Hangzhou 310018, China
*
Author to whom correspondence should be addressed.
Academic Editor: Srinivasulu Aitipamula
Crystals 2016, 6(12), 164; https://doi.org/10.3390/cryst6120164
Received: 1 November 2016 / Revised: 9 December 2016 / Accepted: 13 December 2016 / Published: 16 December 2016
(This article belongs to the Special Issue Novel Pharmaceutical Cocrystals and Their Applications)
Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from the molecule-level, and provides us with rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields. View Full-Text
Keywords: nitrofurantoin; active pharmaceutical ingredient; 4-aminobenzoic acid; cocrystallization; intermolecular interaction; Raman spectroscopy; terahertz spectroscopy nitrofurantoin; active pharmaceutical ingredient; 4-aminobenzoic acid; cocrystallization; intermolecular interaction; Raman spectroscopy; terahertz spectroscopy
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Du, Y.; Cai, Q.; Xue, J.; Zhang, Q. Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid. Crystals 2016, 6, 164.

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