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Current Oncology, Volume 31, Issue 5

May 2024 - 46 articles

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Cover Story: Pancreatic ductal adenocarcinoma (PDAC) ranks third among cancer-related fatalities in Canada, with 7200 new cases and 5900 deaths recorded in 2023. Despite advancements, PDAC patients still face a low median overall survival of around 13%. The majority present with inoperable disease and endure significant symptom burdens, with limited treatment options. Chemotherapy remains the primary approach, but immunotherapy and targeted therapies haven't significantly impacted management. Managing PDAC complexities demands an inter-professional collaborative model, which has shown promise in improving patient outcomes and quality of life. We conducted a retrospective study at the Wallace McCain Centre for Pancreatic Cancer (WMCPC) to evaluate the impact of an inter-professional clinic on patient care and treatment outcomes, hypothesizing that it facilitates timely and tailored treatment plans. View this paper

Articles (46)

  • Article
  • Open Access
2 Citations
2,032 Views
14 Pages

Molecular Markers in Melanoma Progression: A Study on the Expression of miRNA Gene Subtypes in Tumoral vs. Benign Nevi

  • Mihaela Prodan,
  • Sergiu Costescu,
  • Ahmed Elagez,
  • Sorina Maria Denisa Laitin,
  • Vlad Bloanca,
  • Zorin Crainiceanu,
  • Edward Seclaman,
  • Ana-Olivia Toma,
  • Roxana Manuela Fericean and
  • George Puenea
  • + 1 author

17 May 2024

This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi in individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor sta...

  • Protocol
  • Open Access
2 Citations
2,500 Views
7 Pages

Establishing the Top 10 Research Priorities for Adolescent and Young Adult (AYA) Cancer in Canada: A Protocol for a James Lind Alliance Priority Setting Partnership

  • Perri R. Tutelman,
  • Chantale Thurston,
  • Tamara Rader,
  • Brianna Henry,
  • Tristyn Ranger,
  • Mohamed Abdelaal,
  • Michelle Blue,
  • Timothy W. Buckland,
  • Stefanie Del Gobbo and
  • Lexy Dobson
  • + 17 authors

17 May 2024

Adolescents and young adults (AYAs; 15–39 years) diagnosed with cancer have unique medical and psychosocial needs. These needs could be better addressed through research that is focused on the topics that matter most to them. However, there is...

  • Article
  • Open Access
1,945 Views
7 Pages

Pharmacy Workload in Clinical Trial Management: A Preliminary Complexity Assessment Tool for Sponsored Oncology and Haematology Trials

  • Lorenzo Gasperoni,
  • Carla Masini,
  • Giada Toscano,
  • Alessandro Cafaro,
  • Chiara Zani,
  • Cristina Andrianò,
  • Paolo Silimbani,
  • Caterina Donati,
  • Giorgia Bortolin and
  • Sara Cecco

16 May 2024

Investigational drug services need to be organised in a structured approach, especially for sites with a large number of ongoing clinical trials. The aim of this study was to develop a tool to assess the complexity of pharmacy involvement in a sponso...

  • Case Report
  • Open Access
5 Citations
3,966 Views
11 Pages

Multidisciplinary and Tailored Treatment of Locally Advanced Breast Cancer in Progression during Neoadjuvant Chemotherapy: Case Report

  • Letizia Cuniolo,
  • Marco Gipponi,
  • Federica Murelli,
  • Francesca Depaoli,
  • Chiara Cornacchia,
  • Simonetta Franchelli,
  • Marianna Pesce,
  • Elena Ronda,
  • Stefano Picardi and
  • Raquel Diaz
  • + 4 authors

16 May 2024

Locally advanced breast cancer (LABC) is a complex disease that requires a multidisciplinary approach. Neoadjuvant chemotherapy (NAC) is usually performed in order to achieve loco-regional radical resection; although its importance in the multidiscip...

  • Article
  • Open Access
2,228 Views
10 Pages

Discrepancy in the Location of Prostate Cancer Indicated on Biparametric Magnetic Resonance Imaging and Pathologically Diagnosed Using Surgical Specimens

  • Masayuki Tomioka,
  • Keita Nakane,
  • Makoto Kawase,
  • Koji Iinuma,
  • Daiki Kato,
  • Kota Kawase,
  • Tomoki Taniguchi,
  • Yuki Tobisawa,
  • Fumiya Sugino and
  • Tetsuro Kaga
  • + 9 authors

16 May 2024

Accurate diagnosis of the localization of prostate cancer (PCa) on magnetic resonance imaging (MRI) remains a challenge. We aimed to assess discrepancy between the location of PCa pathologically diagnosed using surgical specimens and lesions indicate...

  • Article
  • Open Access
3 Citations
2,116 Views
10 Pages

Trends in Early-Stage Cervical Cancer Management in the US: A National Cancer Database Analysis

  • Jennifer Wolf,
  • Yiyuan Wu,
  • Judy Hayek,
  • Qi Zhang and
  • Ioannis Alagkiozidis

16 May 2024

The Laparoscopic Approach to Cervical Cancer (LACC) trial was published in 2018 and demonstrated that minimally invasive surgery (MIS) yields inferior survival outcomes in early-stage cervical cancer compared to open surgery. This study investigates...

  • Article
  • Open Access
2 Citations
1,847 Views
19 Pages

15 May 2024

This study describes the conception, development, and growth of the Triage Cancer Conference hosted by Triage Cancer, a national nonprofit organization providing free legal and financial education to the cancer community. We conducted a retrospective...

  • Article
  • Open Access
3 Citations
1,529 Views
12 Pages

A Two-Step Approach to the Surgical Treatment of Soft-Tissue Sarcomas

  • Camillo Fulchignoni,
  • Luigi Cianni,
  • Maria Rosaria Matrangolo,
  • Mariagrazia Cerrone,
  • Francesco Cavola,
  • Elisabetta Pataia,
  • Raffaele Vitiello,
  • Giulio Maccauro,
  • Pasquale Farsetti and
  • Giuseppe Rovere

15 May 2024

Background: Nowadays, limb-sparing procedures are the gold standard in the treatment of soft-tissue sarcomas of the limbs. Wide tumor resection with appropriate oncological margins, reconstruction, and stabilization of the involved bone and joint and...

  • Article
  • Open Access
4 Citations
2,718 Views
9 Pages

The Consistency and Quality of ChatGPT Responses Compared to Clinical Guidelines for Ovarian Cancer: A Delphi Approach

  • Dario Piazza,
  • Federica Martorana,
  • Annabella Curaba,
  • Daniela Sambataro,
  • Maria Rosaria Valerio,
  • Alberto Firenze,
  • Basilio Pecorino,
  • Paolo Scollo,
  • Vito Chiantera and
  • Giuseppe Scibilia
  • + 3 authors

14 May 2024

Introduction: In recent years, generative Artificial Intelligence models, such as ChatGPT, have increasingly been utilized in healthcare. Despite acknowledging the high potential of AI models in terms of quick access to sources and formulating respon...

  • Review
  • Open Access
3 Citations
2,825 Views
16 Pages

14 May 2024

Epstein–Barr virus-related post-transplantation lymphoproliferative disorder (EBV-PTLD) is a serious complication following hematopoietic stem cell transplantation (HSCT). A pre-emptive strategy using rituximab, which aims to manage patients ea...

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