Skip Content
You are currently on the new version of our website. Access the old version .

Current Oncology, Volume 33, Issue 1

2026 January - 65 articles

Cover Story: Immunohistochemistry (IHC)-based biomarker studies remain central to oncology, yet their interpretation is subject to multiple sources of variability. This review examines how machine learning (ML)-enabled digital pathology is transforming IHC scoring by enabling reproducible, quantitative, and spatially resolved biomarker assessments. Using clinically validated markers as exemplars, we outline the evolutionary trajectory of automated IHC analysis toward prognostic and predictive applications. With a particular focus on genitourinary (GU) malignancies, we discuss emerging biomarkers and the translational pathway toward clinical implementation. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (65)

  • Review
  • Open Access
120 Views
15 Pages

Artificial Intelligence and Machine Learning in Bone Metastasis Management: A Narrative Review

  • Halil Bulut,
  • Serdar Demiröz,
  • Enes Kanay,
  • Korhan Ozkan and
  • Costantino Errani

Background: Artificial intelligence (AI) and machine learning (ML) are increasingly used in the diagnosis and management of bone metastases, spanning lesion detection, segmentation, prognostic modeling, fracture risk assessment, and surgical decision...

  • Case Report
  • Open Access
160 Views
7 Pages

Anal Squamous Cell Carcinoma with Bilateral Renal Metastases: A Rare Presentation with Literature Review

  • Khujasta Gul,
  • Saivaishnavi Kamatham,
  • Guido Chiriboga,
  • Ahmed Abdelhakeem,
  • Aziza Nassar,
  • Conor O’Donnell and
  • Umair Majeed

Anal squamous cell carcinoma (ASCC) is a rare malignancy of the lower gastrointestinal tract, with distant metastases typically involving the liver and lungs. Metastasis to the kidneys is uncommon, and only one prior case has been reported in the lit...

  • Article
  • Open Access
136 Views
16 Pages

Assessment of Patient Expectations and Preferences Following OPHL: Results from an Evaluation Study

  • Erika Crosetti,
  • Francesca Piccinini,
  • Anastasia Dyrda,
  • Daniela Nassisi,
  • Marco Fantini and
  • Giovanni Succo

Open partial horizontal laryngectomy (OPHL) is a key conservative option for laryngeal cancer, with established oncological outcomes but limited data on functional results and patient perspectives. Voice preservation is mainly associated with type I...

  • Case Report
  • Open Access
186 Views
17 Pages

Two-Stage Surgical Management of Intramedullary Holocord Astrocytoma in an Adult: A Case Report and Literature Review

  • Trong Huy Mai,
  • Firat Taskaya,
  • Sifian Al-Hamid,
  • Julius Reiser,
  • Vanessa Magdalena Swiatek,
  • Ardeshir Ardeshiri,
  • Ali Rashidi,
  • Klaus-Peter Stein,
  • Christian Mawrin and
  • I. Erol Sandalcioglu
  • + 1 author

Background/Objectives: Holocord astrocytomas are exceptionally rare intramedullary tumors, especially in adults, and often present with extensive longitudinal growth. Because only a small number of cases have been described, management strategies rem...

  • Review
  • Open Access
268 Views
21 Pages

SOGUG Multidisciplinary Expert Panel Consensus on Updated Diagnosis and Characterization of Prostate Cancer Patients

  • Enrique Gallardo,
  • Alfonso Gómez-de-Iturriaga,
  • Jesús Muñoz-Rodríguez,
  • Isabel Chirivella-González,
  • Enrique González-Billababeita,
  • Claudio Martínez-Ballesteros,
  • María José Méndez-Vidal,
  • Mercedes Mitjavila-Casanovas,
  • Paula Pelechano Gómez and
  • Fernando López-Campos
  • + 1 author

A group of experts of different specialties involved in the care of prostate cancer (PCa) patients participated in the ENFOCA2 project, promoted by the Spanish Oncology Genitourinary Group (SOGUG), with the aim to review, discuss, and summarize curre...

  • Article
  • Open Access
200 Views
23 Pages

Parent Perspectives on Physical Therapy for Their Child with Acute Lymphoblastic Leukemia: The Light at the End of the Tunnel

  • Paula A. Ospina,
  • Palana Shah,
  • Livleen Dhaliwal,
  • Sara Fisher,
  • Beverly A. Wilson,
  • Lesley Pritchard,
  • David D. Eisenstat and
  • Margaret L. McNeely

Many children with cancer referred to physical therapy (PT) do not attend the service. We conducted a pilot study, comprising a cross-sectional survey and interviews with parents of children with acute lymphoblastic leukemia. The survey explored pare...

  • Review
  • Open Access
434 Views
21 Pages

The Role of Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in the Tumor Microenvironment and Their Impact on Ovarian Cancer Survival and Therapy

  • Alena A. McQuarter,
  • Joseph Cruz,
  • Celina R. Yamauchi,
  • Mariem Chouchen,
  • Cody S. Carter,
  • Tonya J. Webb and
  • Salma Khan

Ovarian cancer is the deadliest gynecologic cancer, mainly because it is often diagnosed late and resists standard treatments. The tumor microenvironment (TME) plays a major role in disease progression and therapy failure. Two key components of the T...

  • Review
  • Open Access
215 Views
16 Pages

Frailty in Hepatocellular Carcinoma: An Unsettled Clinical Challenge

  • Antonio Bonato,
  • Pietro Guerra,
  • Alessandro Vitale and
  • Andrea Martini

Frailty is a clinical syndrome originally described in geriatrics but increasingly recognized across multiple medical fields. A wide variety of clinical tools have been developed to identify and quantify frailty in different contexts. In oncology, th...

  • Article
  • Open Access
235 Views
12 Pages

Clinical Outcomes of Pembrolizumab in Head and Neck Squamous Cell Carcinoma Subsites Excluded from the KEYNOTE-048 Trial

  • Gai Yamashita,
  • Takuro Okada,
  • Isaku Okamoto,
  • Takahito Kondo,
  • Tatsuya Ito,
  • Shota Fujii,
  • Takuma Kishida,
  • Yusuke Aihara,
  • Kenji Hanyu and
  • Kiyoaki Tsukahara
  • + 10 authors

Recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) carries a poor prognosis; however, immune checkpoint inhibitors have emerged as critical therapeutic options. Although the KEYNOTE-048 trial established the efficacy of...

  • Article
  • Open Access
215 Views
11 Pages

Metastasis-Free Survival in Patients with Biochemical Recurrence After Robot-Assisted Radical Prostatectomy: A Multicenter, Retrospective Cohort Study in Japan (MSUG94 Group)

  • Minori Nezasa,
  • Masayuki Tomioka,
  • Tomoyuki Tatenuma,
  • Takeshi Sasaki,
  • Yoshinori Ikehata,
  • Akinori Nakayama,
  • Masahiro Toide,
  • Tatsuaki Yoneda,
  • Kazushige Sakaguchi and
  • Takuya Koie
  • + 6 authors

Robot-assisted radical prostatectomy (RARP) is the definitive surgical treatment for localized prostate cancer (PCa). Some patients with post-RARP biological recurrence (BCR) eventually develop distant metastases and subsequent PCa-related mortality....

of 7

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Curr. Oncol. - ISSN 1718-7729