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Marine Drugs, Volume 19, Issue 4

April 2021 - 55 articles

Cover Story: Screening of the Harbor Branch fraction library against the Plasmodium falciparum chloroquine-resistant strain (Dd2) led to the identification of the novel diterpene, bebrycin A, and the known terpene, nitenin, as potent antiplasmodials with EC50s of 1.08 ± 0.21 and 0.29 ± 0.02 µM, respectively. Assessment of the stage-specific antiplasmodial effects of these inhibitors during the intraerythrocytic life cycle suggests that Bebrycin A blocks maturation at the schizont stage, while early exposure to nitenin may inhibit the maturation of the parasite during the transition from ring to early trophozoite (6–18 HPI), a novel property among known antimalarials. View this paper
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Articles (55)

  • Article
  • Open Access
63 Citations
7,117 Views
13 Pages

Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A

  • M. Mallique Qader,
  • Ahmed A. Hamed,
  • Sylvia Soldatou,
  • Mohamed Abdelraof,
  • Mohamed E. Elawady,
  • Ahmed S. I. Hassane,
  • Lassaad Belbahri,
  • Rainer Ebel and
  • Mostafa E. Rateb

20 April 2021

Epicotripeptin (1), a new cyclic tripeptide along with four known cyclic dipeptides (2–5) and one acetamide derivative (6) were isolated from seagrass-associated endophytic fungus Epicoccum nigrum M13 recovered from the Red Sea. Additionally, two new...

  • Article
  • Open Access
16 Citations
3,366 Views
16 Pages

Electrochromic Properties and Electrochemical Behavior of Marennine, a Bioactive Blue-Green Pigment Produced by the Marine Diatom Haslea ostrearia

  • Nellie Francezon,
  • Mickaël Herbaut,
  • Jean-François Bardeau,
  • Charles Cougnon,
  • William Bélanger,
  • Réjean Tremblay,
  • Boris Jacquette,
  • Jens Dittmer,
  • Jean-Bernard Pouvreau and
  • Jean-Luc Mouget
  • + 1 author

19 April 2021

Marennine has long been known as the unique peculiar pigment responsible for the natural greening of oysters. It is specifically produced by the marine diatom Haslea ostrearia and it is a natural blue molecule indeed promising for food industry becau...

  • Article
  • Open Access
20 Citations
5,272 Views
10 Pages

Rapid Sorting of Fucoxanthin-Producing Phaeodactylum tricornutum Mutants by Flow Cytometry

  • Yong Fan,
  • Xiao-Ting Ding,
  • Li-Juan Wang,
  • Er-Ying Jiang,
  • Phung Nghi Van and
  • Fu-Li Li

17 April 2021

Fucoxanthin, which is widely found in seaweeds and diatoms, has many benefits to human health, such as anti-diabetes, anti-obesity, and anti-inflammatory physiological activities. However, the low content of fucoxanthin in brown algae and diatoms lim...

  • Article
  • Open Access
8 Citations
3,754 Views
10 Pages

Svalbamides A and B, Pyrrolidinone-Bearing Lipodipeptides from Arctic Paenibacillus sp.

  • Young Eun Du,
  • Eun Seo Bae,
  • Yeonjung Lim,
  • Jang-Cheon Cho,
  • Sang-Jip Nam,
  • Jongheon Shin,
  • Sang Kook Lee,
  • Seung-Il Nam and
  • Dong-Chan Oh

17 April 2021

Two new secondary metabolites, svalbamides A (1) and B (2), were isolated from a culture extract of Paenibacillus sp. SVB7 that was isolated from surface sediment from a core (HH17-1085) taken in the Svalbard archipelago in the Arctic Ocean. The comb...

  • Article
  • Open Access
3 Citations
3,335 Views
17 Pages

Two Benthic Diatoms, Nanofrustulum shiloi and Striatella unipunctata, Encapsulated in Alginate Beads, Influence the Reproductive Efficiency of Paracentrotus lividus by Modulating the Gene Expression

  • Francesca Glaviano,
  • Nadia Ruocco,
  • Emanuele Somma,
  • Giuseppe De Rosa,
  • Virginia Campani,
  • Pasquale Ametrano,
  • Davide Caramiello,
  • Maria Costantini and
  • Valerio Zupo

17 April 2021

Physiological effects of algal metabolites is a key step for the isolation of interesting bioactive compounds. Invertebrate grazers may be fed on live diatoms or dried, pelletized, and added to compound feeds. Any method may reveal some shortcomings,...

  • Article
  • Open Access
30 Citations
6,004 Views
19 Pages

16 April 2021

The utilization of bigeye tuna skin as a source of collagen has been increasing the value of these skins. In this study, the quality of the skin was studied first. The skin after 14 h freeze-drying showed a high protein level (65.42% ± 0.06%, db), no...

  • Review
  • Open Access
30 Citations
5,652 Views
11 Pages

Antifungal and Larvicidal Activities of Phlorotannins from Brown Seaweeds

  • Bertoka Fajar Surya Perwira Negara,
  • Jae-Hak Sohn,
  • Jin-Soo Kim and
  • Jae-Suk Choi

16 April 2021

Phlorotannins are secondary metabolites produced by brown seaweeds with antiviral, antibacterial, antifungal, and larvicidal activities. Phlorotannins’ structures are formed by dibenzodioxin, ether and phenyl, ether, or phenyl linkages. The polymeriz...

  • Article
  • Open Access
15 Citations
3,706 Views
12 Pages

Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus

  • Cui-Ping Xing,
  • Dan Chen,
  • Chun-Lan Xie,
  • Qingmei Liu,
  • Tian-Hua Zhong,
  • Zongze Shao,
  • Guangming Liu,
  • Lian-Zhong Luo and
  • Xian-Wen Yang

16 April 2021

Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The...

  • Article
  • Open Access
21 Citations
3,322 Views
12 Pages

Marine-Source Quorum Quenching Enzyme YtnP to Improve Hygiene Quality in Dental Units

  • Xiaohui Sun,
  • Philip Hill,
  • Jia Liu,
  • Jing Qian,
  • Yuting Ma and
  • Shufeng Zhou

16 April 2021

Biofilm in dental unit water lines may pose a health risk to patients and dental practitioners. An AdiC-like quorum quenching enzyme, YtnP, was cloned from a deep-sea probiotic Bacillus velezensis, and heterologously expressed in E. coli to examine t...

  • Article
  • Open Access
19 Citations
4,372 Views
15 Pages

Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases

  • Alberto Ribes-Navarro,
  • Juan C. Navarro,
  • Francisco Hontoria,
  • Naoki Kabeya,
  • Inger B. Standal,
  • Jan O. Evjemo and
  • Óscar Monroig

16 April 2021

Long-chain (C20–24) polyunsaturated fatty acids (LC-PUFAs) are essential nutrients that are mostly produced in marine ecosystems. Previous studies suggested that gammarids have some capacity to endogenously produce LC-PUFAs. This study aimed to inves...

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Mar. Drugs - ISSN 1660-3397