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In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds

1
Department of Biotechnology, Graduate School, Korea University, Seoul 02841, Korea
2
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
3
School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
4
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: María Lourdes Mourelle, Herminia Domínguez and Jose Luis Legido
Mar. Drugs 2021, 19(4), 213; https://doi.org/10.3390/md19040213
Received: 4 March 2021 / Revised: 4 April 2021 / Accepted: 7 April 2021 / Published: 12 April 2021
(This article belongs to the Special Issue Nutra-Cosmeceuticals from Algae for Health and Wellness)
Numerous health benefits of diets containing red seaweeds or agar-derived sugar mixtures produced by enzymatic or acid hydrolysis of agar have been reported. However, among various agar-derived sugars, the key components that confer health-beneficial effects, such as prebiotic and anti-colon cancer activities, remain unclear. Here, we prepared various agar-derived sugars by multiple enzymatic reactions using an endo-type and an exo-type of β-agarase and a neoagarobiose hydrolase and tested their in vitro prebiotic and anti-colon cancer activities. Among various agar-derived sugars, agarotriose exhibited prebiotic activity that was verified based on the fermentability of agarotriose by probiotic bifidobacteria. Furthermore, we demonstrated the anti-colon cancer activity of 3,6-anhydro-l-galactose, which significantly inhibited the proliferation of human colon cancer cells and induced their apoptosis. Our results provide crucial information regarding the key compounds derived from red seaweeds that confer beneficial health effects, including prebiotic and anti-colon cancer activities, to the host. View Full-Text
Keywords: red seaweeds; agarose; agarotriose; 3,6-anhydro-l-galactose; prebiotics; anti-colon cancer activity red seaweeds; agarose; agarotriose; 3,6-anhydro-l-galactose; prebiotics; anti-colon cancer activity
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MDPI and ACS Style

Yun, E.J.; Yu, S.; Kim, Y.-A.; Liu, J.-J.; Kang, N.J.; Jin, Y.-S.; Kim, K.H. In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds. Mar. Drugs 2021, 19, 213. https://doi.org/10.3390/md19040213

AMA Style

Yun EJ, Yu S, Kim Y-A, Liu J-J, Kang NJ, Jin Y-S, Kim KH. In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds. Marine Drugs. 2021; 19(4):213. https://doi.org/10.3390/md19040213

Chicago/Turabian Style

Yun, Eun J., Sora Yu, Young-Ah Kim, Jing-Jing Liu, Nam J. Kang, Yong-Su Jin, and Kyoung H. Kim 2021. "In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds" Marine Drugs 19, no. 4: 213. https://doi.org/10.3390/md19040213

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