Special Issue "Marine Natural Products against Coronaviruses"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editor

Prof. Dr. Orazio Taglialatela-Scafati
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Guest Editor

Special Issue Information

Dear Colleagues,

Coronaviruses are a large group of enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. This group includes various human respiratory diseases: some common colds, Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and the recently appeared COVID-19. Marine Drugs, as the leading journal in reporting marine natural products and their biological/pharmacological/therapeutical applications, would like to provide a publication platform on this topic. Thus, scientists in the marine field are invited to present original and advanced research outcomes about marine natural products with potential efficacy against coronavirus. We welcome both research articles and comprehensive reviews.

Prof. Orazio Taglialatela-Scafati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessFeature PaperArticle
Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study
Mar. Drugs 2020, 18(4), 225; https://doi.org/10.3390/md18040225 - 23 Apr 2020
Cited by 30
Abstract
The current emergency due to the worldwide spread of the COVID-19 caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great concern for global public health. Already in the past, the outbreak of severe acute respiratory syndrome (SARS) in [...] Read more.
The current emergency due to the worldwide spread of the COVID-19 caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great concern for global public health. Already in the past, the outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle Eastern respiratory syndrome (MERS) in 2012 demonstrates the potential of coronaviruses to cross-species borders and further underlines the importance of identifying new-targeted drugs. An ideal antiviral agent should target essential proteins involved in the lifecycle of SARS-CoV. Currently, some HIV protease inhibitors (i.e., Lopinavir) are proposed for the treatment of COVID-19, although their effectiveness has not yet been assessed. The main protease (Mpro) provides a highly validated pharmacological target for the discovery and design of inhibitors. We identified potent Mpro inhibitors employing computational techniques that entail the screening of a Marine Natural Product (MNP) library. MNP library was screened by a hyphenated pharmacophore model, and molecular docking approaches. Molecular dynamics and re-docking further confirmed the results obtained by structure-based techniques and allowed this study to highlight some crucial aspects. Seventeen potential SARS-CoV-2 Mpro inhibitors have been identified among the natural substances of marine origin. As these compounds were extensively validated by a consensus approach and by molecular dynamics, the likelihood that at least one of these compounds could be bioactive is excellent. Full article
(This article belongs to the Special Issue Marine Natural Products against Coronaviruses)
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