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Medicina
Volume 61
Issue 7
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Medicina, Volume 61, Issue 7 (July 2025) – 5 articles

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15 pages, 1201 KiB  
Article
An Evaluation of Turkish Dentists’ Approach to Indirect Pulp Capping and Material Preferences: A Questionnaire-Based Survey
by Baturalp Arslan, Batu Can Yaman, Özge Çeliksöz and Havva Can Aydın
Medicina 2025, 61(7), 1120; https://doi.org/10.3390/medicina61071120 - 20 Jun 2025
Abstract
Background and Objectives: The aim of this study was to evaluate how the indirect pulp
capping treatment approaches and material choices used by dentists actively practicing
in Turkey vary according to demographic data. Materials and Methods: Dentists practicing
in Turkey were included in [...] Read more.
Background and Objectives: The aim of this study was to evaluate how the indirect pulp
capping treatment approaches and material choices used by dentists actively practicing
in Turkey vary according to demographic data. Materials and Methods: Dentists practicing
in Turkey were included in this study. A 13-question survey was used and distributed to
the participants via social media. The statistical analysis of the data obtained from this
study was performed using IBM SPSS v23. The chi-square test was used to compare categorical
variables between groups, and multiple comparisons of the proportions were analyzed
using the Bonferroni correction. The results of the analysis are presented as frequencies
(percentages) for categorical data. The significance level was set at p < 0.05. Results:
A total of 402 dentists from across Turkey participated in this study. A total of 331
participants (82.3%) reported that they performed indirect pulp capping treatment. The
most commonly used materials for indirect pulp capping were Ca(OH)₂-containing liners
(73.4%) and glass ionomer cement (58.3%). The use of amalgam and cotton roll isolation
was more common among dentists working in the public sector, whereas rubber dam
isolation and the use of contemporary materials such as MTA and Biodentine were more
frequently observed among dentists working in the private sector. Conclusions: Significant
differences were found in the dentists’ indirect pulp capping approaches and the materials
they used based on their specialty, years of experience, and workplace setting. These
findings suggest that dentists’ knowledge and experience regarding indirect pulp capping
should be enhanced during their education and post-graduation training. Full article
(This article belongs to the Section Dentistry and Oral Health)
10 pages, 340 KiB  
Article
The Effect of Thymoquinone and Platelet-Rich Plasma on Intra-Abdominal Adhesions
by Gökhan Karaca, Hakan Amioğlu, Mevlüt Recep Pekcici and Huri Demirci
Medicina 2025, 61(7), 1119; https://doi.org/10.3390/medicina61071119 - 20 Jun 2025
Abstract
Background and Objectives: At present, intra-abdominal adhesions (IAAs) continue to be an important problem in surgery due to morbidity and mortality risks. Thymoquinone (TQ) and platelet-rich plasma (PRP) are molecules with known anti-inflammatory and antioxidant effects. However, a limited number of studies have [...] Read more.
Background and Objectives: At present, intra-abdominal adhesions (IAAs) continue to be an important problem in surgery due to morbidity and mortality risks. Thymoquinone (TQ) and platelet-rich plasma (PRP) are molecules with known anti-inflammatory and antioxidant effects. However, a limited number of studies have investigated their efficacy in IAAs. In this study, we aimed to demonstrate the efficacy of TQ and PRP in reducing the development of IAAs and determine which molecule is more advantageous using an experimental animal model. Materials and Methods: Fifty-five male Wistar albino rats were included in the study. Five rats were used to obtain PRP, while fifty rats were randomly assigned to five groups (n = 10 per group): group I (sham) did not receive any treatment; group II (control) received no treatment after a cecum hemorrhage procedure; group III (saline) received 1 mL of saline treatment around the cecum after hemorrhage; group IV (PRP) received 1 mL of PRP (containing 3 × 106 platelets/mL) around the cecum after hemorrhage; and group V (TQ) received 1 mL of TQ (containing 2 mg/mL TQ) around the cecum after hemorrhage. On the 10th day, IL1-β, TNF-α, E-selectin, and P-selectin levels were measured from the blood serum samples, and the cecum was histopathologically evaluated. Results: The lowest adhesion formation in terms of biochemical parameters was obtained in the TQ group (p < 0.05). Histopathological evaluations showed that saline, PRP, and TQ treatments were all effective, but none was superior. Conclusions: When histopathologically evaluated, saline, TQ, and PRP have similar effects in IAAs. However, when evaluated in terms of biochemical parameters, TQ prevented the formation of intra-abdominal adhesions more effectively than saline or PRP, owing to its strong anti-inflammatory and antioxidant properties. Full article
(This article belongs to the Section Pharmacology)
17 pages, 2352 KiB  
Article
An In Vitro Evaluation of the Effect of Ceramic Material, Surface Treatment, and Adhesive Cement on Shear Bond Strength in Prosthodontics
by Izabella Éva Mureșan, Diana Cerghizan, Attila Gergely, Rudolf-László Farmos, László Jakab-Farkas, John-Jason Șimon, Bernadette Kerekes-Máthé, Dóra-Anna Giliga, Esztella Éva Kis, Kinga Mária Jánosi and Krisztina Mártha
Medicina 2025, 61(7), 1118; https://doi.org/10.3390/medicina61071118 - 20 Jun 2025
Abstract
Background and Objectives: Ensuring the optimal shear bond strength (SBS) is essential for the long-term success of prosthodontic restorations. Our in vitro study aimed to evaluate the SBS of three types of ceramics (feldspathic, alumina, and lithium disilicates) using three adhesive cements [...] Read more.
Background and Objectives: Ensuring the optimal shear bond strength (SBS) is essential for the long-term success of prosthodontic restorations. Our in vitro study aimed to evaluate the SBS of three types of ceramics (feldspathic, alumina, and lithium disilicates) using three adhesive cements (Variolink Esthetic LC, Variolink Esthetic DC, and Maxcem Elite). Materials and Methods: Healthy molars were prepared, and ceramic blocks were cemented following universally accepted luting protocols. SBS tests were performed using a custom-made testing machine. A multiple linear regression model assessed the effects of ceramic type, surface treatment, and luting agent on SBS. Results: The regression model explained 61.3% of the variation in SBS values (R2 = 0.613); the adjusted R2 = 0.605 confirmed the model’s robustness. The global F-test was statistically significant (F = 78.96, p < 0.001). The total-etch technique (+4.47), the use of feldspathic ceramic, and 5% hydrofluoric acid treatment (+3.28) significantly affected SBS. Feldspathic ceramic and lithium disilicate showed superior performance against alumina. Light-cured and self-cured cement showed negative effects. Conclusions: Ceramic material and cement type have combined effects on SBS. Optimal results were obtained with the total-etch technique, feldspathic ceramic, 5% hydrofluoric acid treatment, and dual-cured cement. Full article
(This article belongs to the Special Issue Advancements in Dental Medicine, Oral Anesthesiology and Surgery)
12 pages, 452 KiB  
Article
Association Between Hearing Loss and Systemic Small-Vessel Vasculitis: Audiological Aspects Across Disease Types
by Vija Vainutienė, Eugenijus Lesinskas, Tatjana Ivaškienė, Diana Mieliauskaitė, Jolanta Dadonienė, Dalia Miltinienė and Justinas Ivaška
Medicina 2025, 61(7), 1117; https://doi.org/10.3390/medicina61071117 - 20 Jun 2025
Abstract
Background and Objectives: Systemic small-vessel vasculitis (SV) represents a group of rare autoimmune disorders with varied etiologies and clinical manifestations. Audiovestibular involvement in SV may present with a broad spectrum of symptoms, often complicating diagnosis and management. This study aimed to evaluate [...] Read more.
Background and Objectives: Systemic small-vessel vasculitis (SV) represents a group of rare autoimmune disorders with varied etiologies and clinical manifestations. Audiovestibular involvement in SV may present with a broad spectrum of symptoms, often complicating diagnosis and management. This study aimed to evaluate auditory function and speech perception in individuals diagnosed with SV and to investigate associations with disease-specific clinical parameters. Materials and Methods: A total of 40 patients diagnosed with SV (mean age: 48.9 years; range: 28–65 years) were recruited for comprehensive audiological assessment. The evaluation protocol included otoscopic examination, tympanometry, pure-tone audiometry, and speech audiometry. Statistical analysis was conducted using R software (version 4.3.1), and significance was set at p < 0.05. Results: Diagnoses included granulomatosis with polyangiitis (52.5%), eosinophilic granulomatosis with polyangiitis (27.5%), necrotizing vasculopathy (12.5%), and microscopic polyangiitis (7.5%). Mean disease duration was 4.14 years. Hearing complaints were reported by 77.5%; in 20%, they were the initial symptoms. Audiometry identified hearing loss in 50% of patients—predominantly sensorineural (33.8%), followed by mixed (13.7%) and conductive (2.5%) types. Hearing loss was most frequent in necrotizing vasculopathy (60%) and among ANCA-positive individuals (53.7%). Conclusions: Sensorineural hearing loss is common in SV, particularly in ANCA-positive patients, highlighting the need for routine hearing assessment in SV management. Full article
(This article belongs to the Section Hematology and Immunology)
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17 pages, 766 KiB  
Article
Development of the GDF-TRACK-AKI Score for Predicting Acute Kidney Injury in Patients with Rhabdomyolysis Due to Excessive Exercise or Trauma
by Oğuzhan Zengin, Burak Göre, Melike Yakut, Mustafa Yaylalı, Muhammet Göv, Safa Dönmez, Gülhan Kurtoğlu Çelik, Gül Pamukçu Günaydın, Esma Andaç Uzdoğan, Emra Asfuroğlu Kalkan and İhsan Ateş
Medicina 2025, 61(7), 1116; https://doi.org/10.3390/medicina61071116 - 20 Jun 2025
Abstract
Background and Objectives: Rhabdomyolysis is a disorder in which skeletal muscle tissues are damaged, resulting in the escape of their internal substances into the blood circulation. Acute kidney injury (AKI) is a serious complication of rhabdomyolysis that necessitates early recognition to ensure [...] Read more.
Background and Objectives: Rhabdomyolysis is a disorder in which skeletal muscle tissues are damaged, resulting in the escape of their internal substances into the blood circulation. Acute kidney injury (AKI) is a serious complication of rhabdomyolysis that necessitates early recognition to ensure effective clinical management. The objective of this research was to create a practical scoring tool for forecasting AKI in patients experiencing rhabdomyolysis due to trauma or excessive exercise. Materials and Methods: A novel scoring system, termed the growth differentiation factor-15-trauma-creatine kinase acute kidney injury score (GDF-TRACK-AKI score), was established. The model integrates serum levels of growth differentiation factor-15 (GDF-15), creatine kinase (CK), and occurrence of rhabdomyolysis associated with trauma. Clinical and biochemical data were prospectively collected, and the model’s predictive performance was evaluated using receiver operating characteristic ROC curve analysis. Results: Among patients with rhabdomyolysis, those who developed AKI had significantly higher GDF-TRACK-AKI scores (median: 3.00 (IQR: 2.00)) compared to patients without AKI (median: 0.48 (IQR 0.89); p < 0.001). Serum CK and GDF-15 levels were also markedly elevated in the AKI group (p < 0.001). ROC analysis identified a cut-off value of 2.5, providing 67% sensitivity and 98% specificity. Patients with scores ≥ 2 demonstrated a significantly increased risk of AKI. Conclusions: Designed as a practical and dependable tool, the GDF-TRACK-AKI score facilitates prompt identification of kidney injury in patients whose rhabdomyolysis is linked to either trauma or vigorous activity. The integration of trauma history with GDF-15 and CK biomarker data improves risk stratification precision and supports timely treatment decisions. To verify its practical utility and prognostic capabilities, the GDF-TRACK-AKI score should undergo additional evaluation across expansive and demographically varied clinical populations. Full article
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