Molbank, Volume 2012, Issue 3

The heterocyclic carboxylic α-aminoester methyl 2-benzamido-2-(1H-benzimidazol-1-ylmethoxy)acetate is obtained by O-alkylation of methyl α-azido glycinate N-benzoylated with 1H-benzimidazol-1-ylmethanol.

A simple route for synthesis of compound 3 via three component reaction involving ethyl 6-methyl-4-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1), 3-(3,4-dichlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde (2) and monochloro...

2-[(4-Bromophenylimino)methyl]-5-pentadecylphenol has been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with 4-bromoaniline in 1,4-dioxane and its IR, ¹H-NMR, ¹³C-NMR and MS spectroscopic data are presented.

A novel synthesis of a fully substituted fluorescent phenol by a one-pot reaction of dimethyl acetylendicarboxylate and malononitrile in the presence of catalysts has been developed. The structure of the synthesized compound was assigned on the basis...

An hydroxypropyl-aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.

A novel route for the synthesis of new spirocyclic derivative is developed. The present work involves the synthesis of title compound 3 by Suzuki coupling of 3,5-difluorophenyl boronic acid with tert-butyl 1-(5-bromofuran-2-yl)-4-oxo-2,3,7-triazaspir...

A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N-arylation of pyrazolone (1) using copper(I) iodide catalyst followed by reduction to give amine (2). The coupling of 2 wit...

One novel molecular emissive probe L has been synthesized by classical Schiff-base reaction between 1H-indazole-6-carboxaldehyde and tetraethylenepentamine. The structure of compound L was confirmed by melting point, elemental analysis, ESI-MS spectr...

A simple and novel route for synthesis of new spirocyclic amide derivative is developed. The present work involves the oxidative cleavage of tert-butyl 1-(furan-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate 1 followed by the amine couplin...

A novel probe L has been synthesized by classical Schiff-base reaction between 1-benzothiophene-3-carbaldehyde and tetraethylenepentamine as diamine. The structure of compound L was confirmed by melting point, elemental analysis, ESI-MS spectrometry,...

1-Methyl-7-(propan-2-yl)-4-oxatricyclo[5.2.2.0^2,6]undec-8-ene-3,5-dione (1) as starting material and hydroxylamine were used for the preparation of the title compound 4-hydroxy-1-methyl-7-(propan-2-yl)-4-azatricyclo[5.2.2.0^2,6]undec-8-ene-3,5-dione (...

The title compound, 1-(1H-benzimidazol-2-yl)-3-[5-(trichloromethyl)-1,3,4-oxadiazol-2-yl]propan-1-one (2) was synthesized successfully from 4-(1H-benzimidazol-2-yl)-4-oxobutanehydrazide (1) under microwave irradiation in good yield by reacting with t...

The title compound, 2-methoxy-5-{4-oxo-2-[(E)-2-(4-sulfamoylphenyl) ethenyl-3, 4-dihydroquinazolin-3-yl] benzene-1-sulfonamide 2 has been synthesized by the reaction of 3-(4-methoxyphenyl)-2-styryl-4(3H)-quinazolinone 1 with an excess of chlorosulfon...

Novel terphenyl chalcone containing benzimidazole moiety (3) is synthesized by the base-catalyzed Claisen–Schmidt condensation of acetyl terphenyl derivative (1) with 4-(1H-benzimidazol-2-ylmethoxy)-3-methoxybenzaldehyde (2). Newly prepared chalcone...

A new thiosemicarbazone, 1-methyl-2-imino-N-(methanethialdiamine)-yl-4-iminoimidazolidin was synthesized and its UV-VIS, IR, and NMR spectroscopic data and CHN analysis are presented.

A new Schiff base ester, 3-hydroxy-4-[(phenylimino)methyl]phenyl 4-(hexadecanoyloxy)benzoate was synthesized and its IR, ¹H-NMR, ¹³C-NMR and MS spectroscopic data are presented.