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2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III)

Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstraße 14, A- 1090 Vienna, Austria
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Molbank 2012, 2012(3), M772; https://doi.org/10.3390/M772
Received: 27 June 2012 / Accepted: 13 August 2012 / Published: 24 August 2012
An hydroxypropyl-aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively. View Full-Text
Keywords: pyrrole; DNA-alkylation; anticancer pyrrole; DNA-alkylation; anticancer
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Spreitzer, H.; Puschmann, C. 2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III). Molbank 2012, 2012, M772.

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