Table of Contents
Int. J. Mol. Sci., Volume 20, Issue 16 (August-2 2019)
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Cover Story (view full-size image) Although surfactant Protein B (SP-B) plays an essential role in breathing, its structural [...] Read more. Although surfactant Protein B (SP-B) plays an essential role in breathing, its structural mechanisms are still a mystery. SP-B has been proposed to foster lipid structures that promote the absorption of lung surfactant to the air–water interface in alveoli, as well as to refine this material during the breathing cycle. Detailed molecular dynamics simulations help to reveal the structural features and lipid transitions likely to underlie SP-B’s essential functions, including a flexible loop and hinge region that preferentially interact with curved lipid structures. View this paper.