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Special Issue "Electroporation and Electrochemotherapy in Cancer: from Laboratory Models to Human Applications"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 March 2020).

Special Issue Editor

Dr. Alfonso Baldi
Website
Guest Editor
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Caserta, Italy
Interests: electrochemotherapy; cell cycle; apoptosis; cancer biomarkers; endometriosis; melanoma; mesothelioma

Special Issue Information

Dear Colleagues,

Electroporation is a procedure adopted to increase the uptake of molecules by biological targets. Electrochemotherapy is a form of electroporation where the molecules that are to be electroporated in the cells have anti-neoplastic effects. Electrochemotherapy is based on the simple principle that increasing the delivery of chemotherapeutic agents to the cancer cell is able to improve its clinical effectiveness. In recent years, the field of electrochemotherapy has paid increasing attention, through preclinical studies, to the clinic, due to its low cost, feasibility, and efficacy. In human oncology, the adoption of therapeutic protocols based on electrochemotherapy is still largely unknown, and approved indications are still limited. Nevertheless, in several western countries, the use of electrochemotherapy is now approved for the treatment of cutaneous or subcutaneous tumors and for palliative therapy. The principal purpose of this Special Issue is to define a comprehensive and up-to-date overview on electroporation from its theoretical concepts to its applications in human oncology. Furthermore, we will pay due attention to the work of translational research on spontaneous tumors in domestic animals, which represent an important contribution to our understanding of the underlying biological phenomena and the possible applications of human oncology.

Prof. Dr. Alfonso Baldi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Electroporation
  • Electrochemotherapy
  • Human cancer
  • Pet tumor
  • Tumor xenograft
  • Metastasis
  • Palliation

Published Papers (1 paper)

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Research

Open AccessArticle
A Novel Method for Controlled Gene Expression via Combined Bleomycin and Plasmid DNA Electrotransfer
Int. J. Mol. Sci. 2019, 20(16), 4047; https://doi.org/10.3390/ijms20164047 - 19 Aug 2019
Abstract
Electrochemotherapy is an efficient method for the local treatment of cutaneous and subcutaneous metastases, but its efficacy as a systemic treatment remains low. The application of gene electrotransfer (GET) to transfer DNA coding for immune system modulating molecules could allow for a systemic [...] Read more.
Electrochemotherapy is an efficient method for the local treatment of cutaneous and subcutaneous metastases, but its efficacy as a systemic treatment remains low. The application of gene electrotransfer (GET) to transfer DNA coding for immune system modulating molecules could allow for a systemic effect, but its applications are limited because of possible side effects, e.g., immune system overactivation and autoimmune response. In this paper, we present the simultaneous electrotransfer of bleomycin and plasmid DNA as a method to increase the systemic effect of bleomycin-based electrochemotherapy. With appropriately selected concentrations of bleomycin and plasmid DNA, it is possible to achieve efficient cell transfection while killing cells via the cytotoxic effect of bleomycin at later time points. We also show the dynamics of both cell electrotransfection and cell death after the simultaneous electrotransfer of bleomycin and plasmid DNA. Therefore, this method could have applications in achieving the transient, cell death-controlled expression of immune system activating genes while retaining efficient bleomycin mediated cell killing. Full article
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