Special Issue "Electroporation and Electrochemotherapy in Cancer: from Laboratory Models to Human Applications"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2020).
Interests: electrochemotherapy; cell cycle; apoptosis; cancer biomarkers; endometriosis; melanoma; mesothelioma
Electroporation is a procedure adopted to increase the uptake of molecules by biological targets. Electrochemotherapy is a form of electroporation where the molecules that are to be electroporated in the cells have anti-neoplastic effects. Electrochemotherapy is based on the simple principle that increasing the delivery of chemotherapeutic agents to the cancer cell is able to improve its clinical effectiveness. In recent years, the field of electrochemotherapy has paid increasing attention, through preclinical studies, to the clinic, due to its low cost, feasibility, and efficacy. In human oncology, the adoption of therapeutic protocols based on electrochemotherapy is still largely unknown, and approved indications are still limited. Nevertheless, in several western countries, the use of electrochemotherapy is now approved for the treatment of cutaneous or subcutaneous tumors and for palliative therapy. The principal purpose of this Special Issue is to define a comprehensive and up-to-date overview on electroporation from its theoretical concepts to its applications in human oncology. Furthermore, we will pay due attention to the work of translational research on spontaneous tumors in domestic animals, which represent an important contribution to our understanding of the underlying biological phenomena and the possible applications of human oncology.
Prof. Dr. Alfonso Baldi
Manuscript Submission Information
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- Human cancer
- Pet tumor
- Tumor xenograft