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Special Issue "Nanotoxicology and Nanosafety 2.0"
Deadline for manuscript submissions: 29 February 2020.
Interests: nanotoxicology; environmental toxicology; ecotoxicology; nanosafety; alternative testing methods; regulatory toxicology; adverse outcome pathways
With the rapid development of nanotechnology, nanomaterials have been widely applied in many industrial sectors, including medicine, consumer products, and electronics. While such technology has brought benefits and convenience into our daily lives, it may also potentially threaten human health and environmental safety. However, knowledge of the adverse health effects of these nanomaterials is still very limited. In this Special Issue, we hope to bring together significant research that advances the knowledge base on the adverse effects of nanomaterials, as well as the regulatory aspects of nanomaterials. In vitro, in vivo, and human studies that contribute to our understanding of human health and environmental impacts are welcome. Of particular interest will be papers that describe studies where modes of action and adverse outcome pathways could be evaluated during nanomaterials intoxication. In addition, alternative testing methods using zebrafish, drosophila, and C. Elegant are also welcome. This Special Issue will focus on the publication of original manuscripts and critical reviews to advance our understanding of the possible health effects of nanomaterials, as well as the means to protect workers and consumers exposed to them.
Prof. Dr. Ying-Jan Wang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- molecular and cellular mechanisms of nanomaterials intoxication
- regulatory toxicology
- alternative testing methods
- ecotoxicity of nanomaterials
- adverse effects of nanomaterials in zebrafish
- adverse effects of nanomaterials in drosophila
- adverse effects of nanomaterials in C. Elegant
- risk assessment of engineered nanomaterials
- risk management of engineered nanomaterials
- biological monitoring of engineered nanomaterials
- environmental monitoring of engineered nanomaterials
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Magnetic nanoparticles toxicity on larvae and adult fish.
Nemi Malhotra 1, Tzong-Rong Ger 1 * and Chung-Der Hsiao 2,3,4 *
- Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 32023, Taiwan
- Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan
- Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan
- Center for Nanotechnology, Chung Yuan Christian University, Chung-Li 32023, Taiwan
The noteworthy intensification in development of nanotechnology, has led to development of various nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, cosmetics, medicine, electronics, contrast agents for MRI and so on. Magnetic nanoparticles are a branch of nanoparticle’s which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles. Besides the mentioned advantages, the toxicity of these magnetic nanoparticles is still less explored. Some nanoparticles have demonstrated the toxic effect on plants, cell lines as well as animal models, such as causing inflammation, ulceration, decrease in growth rate and decline in viability. The cause of nanoparticles toxicity is attributed to its specific characteristics of greater surface to volume ratio, surface coatings, size, dosage, retention in body, breakdown and elimination from body. In the current review paper, we therefore aim to sum up the toxicity effect of different magnetic nanoparticles on fish embryo/larvae and adults. As an important vertebrate model for assessing the effect of drugs fish has gained tremendous popularity. Also, the characteristic features of short reproductive cycle, transparency for visual assessment of developing organs and ease of maintenance make fish a good model for toxicity valuation. Therefore, we believe attaining a profound knowledge on the background of the subject we might get some insights on the field to give research in this field a new sustainable direction.
Nano-plastics Cause Neurobehavioral Impairments, Oxidative Damage and Biomarker Response in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure
Sreeja Sarasamma 1,2 #, Gilbert Audira 1,2 #, Petrus Siregar 2, Yu-Heng Lai 3, Sung-Tzu Liang 2, Jung-Ren Chen 4 * and Chung-Der Hsiao 1,2,4,5 *
- Department of Chemistry, Chung Yuan Christian University, Chung-Li, 32023, Taiwan
- Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, 32023, Taiwan
- Department of Biological Science & Technology, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan
- Department of Chemistry, Chinese Culture university, Taipei, 11114, Taiwan
- Center for Nanotechnology, Chung Yuan Christian University, Chung-Li, 32023, Taiwan
＊ Corresponding: Jung-Ren Chen ([email protected]); Department of Biological Science & Technology, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan; Chung-Der Hsiao ([email protected]); Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, 32023, Taiwan
BACKGROUND: Plastic pollution is a growing global emergency and it could serve as a geological indicator of the Anthropocene era. Micro-plastics are potentially more hazardous than macro-plastics as the former can permeate biological membranes.
OBJECTIVE: Toxicity of micro-plastic exposure on humans and aquatic organisms has been documented, but the toxicity and behavioral changes of nano-plastics in mammals is scarce. Despite their small size nano-plastics have an enormous surface area, bearing the potential to bind an even bigger amounts of toxic compounds than micro-plastics.
METHODS: Here we used polystyrene (PS) nano-plastics (diameter size at ~70nm) to investigate the neurobehavioral alterations, tissue distribution, accumulation and specific health risk of nano-plastics (NPs) in adult zebrafish.
RESULTS: Results demonstrated that NPs accumulated in gonads, intestine, liver and brain with a tissue distribution pattern greatly dependent on the size and shape of the NPs particle. Importantly, analysis of multiple behavior endpoints, different biochemical biomarkers and histology evidenced that NPs exposure induced disturbance of lipid and energy metabolism as well as oxidative stress and tissue accumulation. Moreover, neurotransmitter biomarkers of neurotoxicity were significantly altered after one week of NPs exposure.
CONCLUSION: Our results revealed the accumulation and distribution of NPs across zebrafish tissues and demonstrated significant changes in several biomarkers that indicate potential toxicity from NPs exposure. Overall, our results provided new evidence for the adverse consequences of NPs-induced behavioral dysregulation and changes at the molecular level that eventually reduce the survival fitness of zebrafish in the ecosystem.