Special Issue "Pathophysiological and Molecular Mechanisms in Non-alcoholic Fatty Liver Disease"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2019
The worldwide obesity epidemic has increased the incidence of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). NAFLD prevalence is now estimated to be 25% of the world population and is the most common cause of liver transplantation. Although several mechanisms have been hypothesized, further research is needed to understand genetic modifiers, natural history, and the molecular pathogenesis of NAFLD, as well as the biological mechanisms by which NAFLD progresses to non-alcoholic steatohepatitis (NASH), influences the risk of hepatocarcinoma (HCC) and extra-hepatic diseases. Furthermore, the impact of environment (e.g., exposure to bacteria, virus or pollutants) on the onset of NAFLD and metabolic abnormalities is becoming evident.
This Special Issue of IJMS, will cover a selection of original articles and current reviews in the field of “Pathophysiological Molecular Mechanisms of Non-Alcoholic Fatty Liver Disease ".
We invite investigators to contribute either original research articles or review articles focusing on the variety of mechanisms that either contribute to the onset and worsening of NAFLD in lean vs obese patients, in type 2 diabetic vs non diabetics subjects and to the development of hepatocellular carcinoma in NASH.
Prof. Dr. Amalia Gastaldelli
Prof. Dr. Silvia Fargion
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Metabolic vs genetic NAFLD
- Alterations in lipid synthesis and lipid composition
- Ectopic fat accumulation, lipotoxicity and lipid mediated cell signaling
- Metabolomics and lipidomics
- Protein metabolism and sarcopenia
- NAFLD and virus
- Gut liver axis, gut microbiota and gut hormones
- Bile acids
- Mitochondrial function in NAFLD
- Energy expenditure and Exercise
- Food composition and different types of diets
- Environmental factors that can promote NAFLD
- Fibrosis in NAFLD
- Hepatocellular carcinoma in NASH