Pathophysiological and Molecular Mechanisms in Non-alcoholic Fatty Liver Disease

Dear Colleagues,

The worldwide obesity epidemic has increased the incidence of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). NAFLD prevalence is now estimated to be 25% of the world population and is the most common cause of liver transplantation. Although several mechanisms have been hypothesized, further research is needed to understand genetic modifiers, natural history, and the molecular pathogenesis of NAFLD, as well as the biological mechanisms by which NAFLD progresses to non-alcoholic steatohepatitis (NASH), influences the risk of hepatocarcinoma (HCC) and extra-hepatic diseases. Furthermore, the impact of environment (e.g., exposure to bacteria, virus or pollutants) on the onset of NAFLD and metabolic abnormalities is becoming evident. 

This Special Issue of IJMS, will cover a selection of original articles and current reviews in the field of “Pathophysiological Molecular Mechanisms of Non-Alcoholic Fatty Liver Disease ".

We invite investigators to contribute either original research articles or review articles focusing on the variety of  mechanisms that either contribute to the onset and worsening of NAFLD in lean vs obese patients, in  type 2 diabetic vs non diabetics subjects and to the development of hepatocellular carcinoma in NASH.

Prof. Dr. Amalia Gastaldelli
Prof. Dr. Silvia Fargion
Guest Editors

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