Special Issue "Peptidylarginine Deiminases and Protein Deimination in Health and Disease"
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 40341
Interests: peptidylarginine deiminases; tissue remodelling; extracellular vesicles; CNS regeneration; cancer; mucosal immunity; innate immunity; stem cells
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Topics: Animal Models of Human Disease
Peptidylarginine deiminases (PADs) are a group of calcium-dependent enzymes that are conserved throughout phylogeny and involved in physiological and pathophysiological processes. PADs cause post-translational deimination of proteins by converting arginine into citrulline (citrullination/deimination), resulting in structural and functional changes in target proteins.
The field of PADs has grown increasingly in the past few years with PADs and post-translational deimination being widely studied in autoimmune and neurodegenerative pathologies as well as in cancer. Protein deimination has, for example, been found to be involved in neo-epitope generation in autoimmunity, as well as neurodegeneration and inflammation, in epigenetic regulation via histone deimination in cancers and in the regulation of extracellular vesicle release.
The development of PAD inhibitors and PAD-knockout models has helped in elucidating some PAD-mediated roles in various pathologies. Protective roles for pharmacological PAD inhibitors have for example been shown in several animal models of autoimmunity and acute CNS injury, while regulatory roles for PAD inhibitors on histone modifications and extracellular vesicle release have been implicated in cancers, including sensitisation to chemotherapy.
While the physiological roles of PADs have been less studied, implications have been found in CNS development, embryo-preimplantation and in mucosal and innate immunity, among others. Post-translational protein changes, such as protein deimination, may facilitate protein moonlighting, an evolutionary acquired phenomenon where proteins are allowed to exhibit more than one physiologically relevant function within one polypeptide chain.
This Special Issue aims to collect state-of-the-art primary research studies and review articles from international experts and diverse leading groups in the field to update our current understanding of the contributions of PADs in both physiological and pathophysiological processes.
Dr. Sigrun Lange
Prof. Dr. Anthony P Nicholas
Manuscript Submission Information
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- Peptidylargine deiminases
- Posttranslational protein deimination
- CNS injury
- PAD antagonists
- PAD animal models