Next Article in Journal
Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo
Next Article in Special Issue
Migration of Small Ribosomal Subunits on the 5′ Untranslated Regions of Capped Messenger RNA
Previous Article in Journal
Role of Autophagy in Zinc Oxide Nanoparticles-Induced Apoptosis of Mouse LEYDIG Cells
Previous Article in Special Issue
A tRNA-mimic Strategy to Explore the Role of G34 of tRNAGly in Translation and Codon Frameshifting
Open AccessReview

Control of Translation at the Initiation Phase During Glucose Starvation in Yeast

1
EMBL-Australia Collaborating Group, Department of Genome Sciences, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
2
Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(16), 4043; https://doi.org/10.3390/ijms20164043
Received: 1 July 2019 / Revised: 10 August 2019 / Accepted: 15 August 2019 / Published: 19 August 2019
(This article belongs to the Special Issue Structure, Function and Evolution of the Ribosome)
Glucose is one of the most important sources of carbon across all life. Glucose starvation is a key stress relevant to all eukaryotic cells. Glucose starvation responses have important implications in diseases, such as diabetes and cancer. In yeast, glucose starvation causes rapid and dramatic effects on the synthesis of proteins (mRNA translation). Response to glucose deficiency targets the initiation phase of translation by different mechanisms and with diverse dynamics. Concomitantly, translationally repressed mRNAs and components of the protein synthesis machinery may enter a variety of cytoplasmic foci, which also form with variable kinetics and may store or degrade mRNA. Much progress has been made in understanding these processes in the last decade, including with the use of high-throughput/omics methods of RNA and RNA:protein detection. This review dissects the current knowledge of yeast reactions to glucose starvation systematized by the stage of translation initiation, with the focus on rapid responses. We provide parallels to mechanisms found in higher eukaryotes, such as metazoans, for the most critical responses, and point out major remaining gaps in knowledge and possible future directions of research on translational responses to glucose starvation. View Full-Text
Keywords: nutrient stress; glucose starvation; stress response; eukaryotic translation; eukaryotic protein synthesis control; rapid response to stress; translation mechanisms; translation initiation; mRNA; mRNP; ribosome; eIF; 5’UTR; UTR; stress granules nutrient stress; glucose starvation; stress response; eukaryotic translation; eukaryotic protein synthesis control; rapid response to stress; translation mechanisms; translation initiation; mRNA; mRNP; ribosome; eIF; 5’UTR; UTR; stress granules
Show Figures

Figure 1

MDPI and ACS Style

Janapala, Y.; Preiss, T.; Shirokikh, N.E. Control of Translation at the Initiation Phase During Glucose Starvation in Yeast. Int. J. Mol. Sci. 2019, 20, 4043.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop