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Molecules, Volume 26, Issue 22

November-2 2021 - 307 articles

Cover Story: The triazolopyrimidine derivatives are valuable pharmacophores due to their resemblance with purine bases. Hence, they are used as scaffolds to obtain metal complexes with superior biological performance, and especially Cu(II) species, due to their essential character for humans, as well as redox and stereochemical versatility. By combining these synthons, we have synthesized new species with antiproliferative effect on murine melanoma B16 cells, low toxicity on normal BJ cells and no effect on the membrane integrity. The complexes exhibit also a potent antimicrobial activity on Gram-positive strains, including methicillin-resistant Staphylococcus aureus, DNA intercalative ability, and nuclease-like activity. View this paper
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Articles (307)

  • Article
  • Open Access
6 Citations
3,000 Views
15 Pages

Theoretical Thermodynamic Efficiency Limit of Isothermal Solar Fuel Generation from H2O/CO2 Splitting in Membrane Reactors

  • Hongsheng Wang,
  • Hui Kong,
  • Jian Wang,
  • Mingkai Liu,
  • Bosheng Su and
  • Sean-Thomas B. Lundin

22 November 2021

Solar fuel generation from thermochemical H2O or CO2 splitting is a promising and attractive approach for harvesting fuel without CO2 emissions. Yet, low conversion and high reaction temperature restrict its application. One method of increasing conv...

  • Article
  • Open Access
30 Citations
3,731 Views
14 Pages

22 November 2021

Graphitic carbon nitride (g-C3N4) photocatalysts were synthesized via a one-step pyrolysis process using melamine, dicyandiamide, thiourea, and urea as precursors. The obtained g-C3N4 materials exhibited a significantly different performance for the...

  • Review
  • Open Access
69 Citations
10,448 Views
33 Pages

22 November 2021

The creation of new bonds via C-F bond cleavage of readily available per- or oligofluorinated compounds has received growing interest. Using such a strategy, a myriad of valuable partially fluorinated products can be prepared, which otherwise are dif...

  • Article
  • Open Access
13 Citations
3,050 Views
12 Pages

22 November 2021

Between 293.2 and 313.2 K and at 0.1 MPa, the solubility of the weak base, cinnarizine (CNZ) (3), in various {Transcutol-P (TP) (1) + water (2)} combinations is reported. The Hansen solubility parameters (HSP) of CNZ and various {(TP) (1) + water (2)...

  • Review
  • Open Access
113 Citations
12,150 Views
13 Pages

22 November 2021

Lactic acid bacteria (LAB) are Gram-positive and catalase-negative microorganisms used to produce fermented foods. They appear morphologically as cocci or rods and they do not form spores. LAB used in food fermentation are from the Lactobacillus and...

  • Article
  • Open Access
6 Citations
3,096 Views
13 Pages

Synthesis and Characterization of the Ethylene-Carbonate-Linked L-Valine Derivatives of 4,4-Dimethylcurcumin with Potential Anticancer Activities

  • Der-Yen Lee,
  • Hui-Yi Lin,
  • Manickavasakam Ramasamy,
  • Sheng-Chu Kuo,
  • Pei-Chih Lee and
  • Min-Tsang Hsieh

22 November 2021

Natural phenolic products from herbal medicines and dietary plants constitute the main source of lead compounds for the development of the new drug. 4,4-Dimethylcurcumin (DMCU) is a synthetic curcumin derivative and exhibits anticancer activities aga...

  • Review
  • Open Access
34 Citations
13,325 Views
20 Pages

Peptide Regulation of Gene Expression: A Systematic Review

  • Vladimir Khatskelevich Khavinson,
  • Irina Grigor’evna Popovich,
  • Natalia Sergeevna Linkova,
  • Ekaterina Sergeevna Mironova and
  • Anastasiia Romanovna Ilina

22 November 2021

Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems. The mechanism of such action of peptides involves their ability to regulate gene expression and protein synt...

  • Article
  • Open Access
23 Citations
4,368 Views
24 Pages

22 November 2021

In this study, the blueberries (BLUB), raspberries (RASB), blackberries (BLCB), pomegranates pomace (POME) and beetroots (BEET) freeze-dried powders were used as the sources of phenolic compounds to enrich different types of chocolates, substituting...

  • Article
  • Open Access
1 Citations
2,465 Views
15 Pages

22 November 2021

The excellent suspension stability of the high-viscosity linear polysiloxane magnetorheological fluid (HVLP MRF) makes it a great controlled medium for magnetorheological energy absorbers (MREAs). In our previous work, the Herschel–Bulkley flow...

  • Article
  • Open Access
20 Citations
4,848 Views
12 Pages

22 November 2021

Alzheimer’s disease (AD) is a severe neurodegenerative disorder. AD is pathologically characterized by the formation of intracellular neurofibrillary tangles, and extracellular amyloid plaques which were comprised of amyloid-beta (Aβ) pept...

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Molecules - ISSN 1420-3049