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Review

Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health

1
South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, Institute of Aquaculture and Protection of Waters, University of South Bohemia in České Budějovice, Na Sádkách 1780, 37005 České Budějovice, Czech Republic
2
Institute of Entomology, Biology Centre, Czech Academy of Science, 37005 České Budějovice, Czech Republic
3
Department of Parasitology, Faculty of Science, University of South Bohemia, 37005 České Budějovice, Czech Republic
4
Institute of Plant Genetics, Polish Academy of Sciences, 34 Strzeszynska Street, 60-479 Poznan, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Natalizia Miceli
Molecules 2021, 26(22), 7036; https://doi.org/10.3390/molecules26227036
Received: 20 October 2021 / Revised: 15 November 2021 / Accepted: 16 November 2021 / Published: 21 November 2021
Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C20H30O5) isolated from Andrographis paniculate (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster. View Full-Text
Keywords: Andrographis paniculata (AP); andrographolide (AGL); anti-manic; anti-microbial; COVID-19 epidemic; immune booster; herbal-chemo remedy Andrographis paniculata (AP); andrographolide (AGL); anti-manic; anti-microbial; COVID-19 epidemic; immune booster; herbal-chemo remedy
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MDPI and ACS Style

Mishra, A.; Shaik, H.A.; Sinha, R.K.; Shah, B.R. Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health. Molecules 2021, 26, 7036. https://doi.org/10.3390/molecules26227036

AMA Style

Mishra A, Shaik HA, Sinha RK, Shah BR. Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health. Molecules. 2021; 26(22):7036. https://doi.org/10.3390/molecules26227036

Chicago/Turabian Style

Mishra, Archana, Haq A. Shaik, Rakesh K. Sinha, and Bakht R. Shah. 2021. "Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health" Molecules 26, no. 22: 7036. https://doi.org/10.3390/molecules26227036

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