Molecules, Volume 23, Issue 2 (February 2018) – 290 articles
Cover Story (view full-size image): Biocatalysts able to convert nitroaromatics to aromatic amines are in high demand, yet they are not commonly found in nature and only succeed for a small number of known substrates. The question therefore is “Why”? We show that substrates with large pi systems-bearing electron withdrawing groups, are more likely to form amines. Crucially, nitroreductases accommodate many such substrates. We attribute this to their intertwined architecture that supports very diverse active site shapes and sizes. This segregation of core structure vs. catalytic site, eminently suits the engineering of nitroreductases. View this paper
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