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Palliative and Precision Medicine Treatment for Biliary Tract Cancers (BTCs)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 July 2026) | Viewed by 1074

Editor


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Guest Editor
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
Interests: minimally invasive hepatobiliary surgery; liver transplantation; systemic treatment of biliary tract cancer

Special Issue Information

Dear Colleagues,

Biliary tract cancers (BTCs) represent a group of highly heterogeneous malignancies with poor prognosis, posing significant challenges in diagnosis and treatment. With advances in precision medicine, targeted therapies (e.g., against FGFR2 fusions, IDH1 mutations) and immunotherapies have brought new hope for patients with advanced BTC. However, integrating these cutting-edge developments effectively with palliative care to optimize patients’ quality of life and prolong survival remains a critical issue in clinical practice. This Special Issue aims to compile the latest research in the field, focusing on the application of precision medicine strategies in personalized BTC treatment and the central role of palliative care throughout disease management. We welcome original research articles, reviews, and that emphasize biomarker-guided targeted therapy, innovations in immunotherapy, symptom management, supportive care, and improvements in patient quality of life.

Dr. Xiaoyong Huang
Guest Editor

Manuscript Submission Information

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Keywords

  • biliary tract cancers
  • precision medicine
  • palliative care
  • targeted therapy
  • immunotherapy

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Published Papers (1 paper)

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Review

25 pages, 2974 KB  
Review
Prognostic, Predictive, and Clinical Relevance of DNA Damage Repair Alterations in Biliary Tract Cancers
by Jawad Tarfouss, Oier Azurmendi Senar, Kosta Stosic, Laurine Verset, Christelle Bouchart, Julie Navez, Jean-Luc Van Laethem, Anne Demols and Tatjana Arsenijevic
Cancers 2026, 18(13), 2134; https://doi.org/10.3390/cancers18132134 - 1 Jul 2026
Viewed by 671
Abstract
Biliary tract cancers (BTCs) comprise a heterogeneous group of malignancies arising from the biliary tree, including cholangiocarcinomas and gallbladder carcinomas. Although their incidence is rising globally in Western countries, these cancers are rare and most often diagnosed at advanced stages. Their molecular heterogeneity [...] Read more.
Biliary tract cancers (BTCs) comprise a heterogeneous group of malignancies arising from the biliary tree, including cholangiocarcinomas and gallbladder carcinomas. Although their incidence is rising globally in Western countries, these cancers are rare and most often diagnosed at advanced stages. Their molecular heterogeneity and frequent resistance to therapy further contribute to their dismal prognosis. In recent years, molecular profiling studies have led to a better understanding of BTC biology and have opened new therapeutic opportunities, particularly for patients with advanced or metastatic disease. Alterations in DNA damage repair (DDR) genes have been identified in a substantial proportion of BTC cases, with some cohorts observing frequencies approaching ~70%. These genetic alterations play a critical role in tumorigenesis and disease progression and may contribute to treatment resistance. In this article, we discuss the current knowledge on: (1) the main DDR signaling pathways; (2) the prevalence of DDR gene alterations across BTC subtypes; (3) the potential of DDR gene alterations as prognostic and/or predictive biomarkers of treatment response; and (4) the latest advances in DDR-based targeted therapies and ongoing clinical trials in BTC. Full article
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