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23 Results Found

  • Review
  • Open Access
12 Citations
5,975 Views
13 Pages

The Role of Rosavin in the Pathophysiology of Bone Metabolism

  • Piotr Wojdasiewicz,
  • Paweł Turczyn,
  • Anna Lach-Gruba,
  • Łukasz A. Poniatowski,
  • Daryush Purrahman,
  • Mohammad-Reza Mahmoudian-Sani and
  • Dariusz Szukiewicz

9 February 2024

Rosavin, a phenylpropanoid in Rhodiola rosea’s rhizome, and an adaptogen, is known for enhancing the body’s response to environmental stress. It significantly affects cellular metabolism in health and many diseases, particularly influenci...

  • Article
  • Open Access
2,233 Views
13 Pages

The Effect of Rosavin, a Characteristic Compound of Rhodiola rosea, on BMP-2 Induction and Osteoblast Proliferation In Vitro

  • Piotr Wojdasiewicz,
  • Edyta Wróbel,
  • Krzysztof Stolarczyk,
  • Elżbieta U. Stolarczyk,
  • Agnieszka Mikulska and
  • Dariusz Szukiewicz

Rosavin, a glycoside isolated from Rhodiola rosea, exhibits various biological activities, including potential modulation of metabolic pathways. Despite promising findings in animal models, its effects on many human bone cells remain unexplored. This...

  • Review
  • Open Access
17 Citations
7,612 Views
15 Pages

3 November 2023

Rhodiola rosea L. (RRL) is a popular plant in traditional medicine, and Rosavin, a characteristic ingredient of RRL, is considered one of the most important active ingredients in it. In recent years, with deepening research on its pharmacological act...

  • Article
  • Open Access
20 Citations
4,887 Views
19 Pages

Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death

  • Reda Albadawy,
  • Amany Helmy Hasanin,
  • Sara H. A. Agwa,
  • Shaimaa Hamady,
  • Yasmin M. Aboul-Ela,
  • Mona Hussien Raafat,
  • Samaa Samir Kamar,
  • Mohamed Othman,
  • Yahia A. Yahia and
  • Marwa Matboli

5 September 2022

Background: Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease that urgently needs effective therapy. Rosavin, a major constituent of the Rhodiola Rosea plant of the family Crassulaceae, is believed to...

  • Article
  • Open Access
9 Citations
3,212 Views
24 Pages

Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4/NF-κB/MAPK Singnaling Pathways

  • Qiao-Hui Liu,
  • Ke Zhang,
  • Shu-Shu Feng,
  • Li-Juan Zhang,
  • Shun-Ying Li,
  • Hang-Yu Wang and
  • Jin-Hui Wang

3 February 2024

Acute lung injury (ALI) is a serious inflammatory disease with high morbidity and mortality. Rosavin is an anti-inflammatory and antioxidant phenylpropanoid and glucoside, which is isolated from Rhodiola rosea L. However, its potential molecular mech...

  • Article
  • Open Access
32 Citations
1,794 Views
8 Pages

Evaluation of biologically active compounds in roots and rhizomes of Rhodiola rosea L. cultivated in Lithuania

  • Agnė Kučinskaitė,
  • Loretta Pobłocka-Olech,
  • Mirosława Krauze-Baranowska,
  • Małgorzata Sznitowska,
  • Arūnas Savickas and
  • Vitalis Briedis

16 June 2007

Salidroside and rosavins (rosavin, rosarin, and rosin), biologically active compounds of Rhodiola rosea L., were analyzed in dried roots and rhizomes of the plants cultivated in Lithuania and naturally growing in Altai geographical region in Russian...

  • Article
  • Open Access
3 Citations
3,550 Views
11 Pages

28 November 2022

Artic root is a well-known plant adaptogen with multipotential pharmacological properties. Thin-layer chromatography (TLC)—screening followed by diode-array high-performance liquid chromatography and nuclear magnetic resonance spectroscopy prov...

  • Article
  • Open Access
4 Citations
2,880 Views
17 Pages

In this study, growth parameters of underground parts and concentrations of phenylpropanoids, phenylethanoids, flavonoids, hydroxybenzoic acids, and catechins in aqueous–ethanol extracts of 6-year-old cultivated plants of Rhodiola rosea (propag...

  • Article
  • Open Access
66 Citations
10,194 Views
14 Pages

Antioxidant and Antibacterial Activity of Roseroot (Rhodiola rosea L.) Dry Extracts

  • Olga Kosakowska,
  • Katarzyna Bączek,
  • Jarosław L. Przybył,
  • Ewelina Pióro-Jabrucka,
  • Weronika Czupa,
  • Alicja Synowiec,
  • Małgorzata Gniewosz,
  • Rosaria Costa,
  • Luigi Mondello and
  • Zenon Węglarz

Roseroot (Rhodiola rosea L.) belongs to plants revealing adaptogenic properties, which are attributed to the presence of specific phenolic compounds and are reflected mainly as antioxidant activity. The aim of the present study was to determine the a...

  • Article
  • Open Access
19 Citations
3,819 Views
12 Pages

Variability of Major Phenyletanes and Phenylpropanoids in 16-Year-Old Rhodiola rosea L. Clones in Norway

  • Abdelhameed Elameen,
  • Vera M. Kosman,
  • Mette Thomsen,
  • Olga N. Pozharitskaya and
  • Alexander N. Shikov

30 July 2020

Rhodiola rosea L. (roseroot) is an adaptogen plant belonging to the Crassulaceae family. The broad spectrum of biological activity of R. rosea is attributed to its major phenyletanes and phenylpropanoids: rosavin, salidroside, rosin, cinnamyl alcohol...

  • Article
  • Open Access
2 Citations
2,498 Views
10 Pages

The Effect of Low Positive Temperatures on the Formation of Secondary Metabolites in Rhodiola quadrifida (Pall.) Fisch. et C.A. Mey. In Vitro Cultures

  • Anna Y. Stepanova,
  • Evgeny A. Gladkov,
  • Dmitry V. Tereshonok,
  • Renat N. Selimov,
  • Elisaveta N. Goncharova and
  • Aleksandra I. Solov’eva

23 December 2022

Global warming is one of the most serious problems leading to changes in the distribution areas of species and biodiversity. Rhodiola quadrifida is a rare plant with adaptogenic properties and grows in the highlands in a narrow temperature range of 2...

  • Article
  • Open Access
79 Citations
6,488 Views
11 Pages

Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

  • Alexander N. Shikov,
  • Vera M. Kosman,
  • Elena V. Flissyuk,
  • Irina E. Smekhova,
  • Abdelhameed Elameen and
  • Olga N. Pozharitskaya

16 April 2020

The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett–Burman design with five variables, followed by the steepest asc...

  • Article
  • Open Access
9 Citations
4,830 Views
9 Pages

13 December 2021

Rhodiola rosea produces nearly 150 bioactive compounds. Cinnamyl alcohol glycosides (CAGs) are among the most important secondary metabolites which are specific to this plant species, exhibiting adaptogenic properties along with salidroside. However,...

  • Article
  • Open Access
36 Citations
7,447 Views
14 Pages

Qualitative and Quantitative Analysis of Different Rhodiola rosea Rhizome Extracts by UHPLC-DAD-ESI-MSn

  • Fabian Alperth,
  • Ivana Turek,
  • Sandra Weiss,
  • Dietmar Vogt and
  • Franz Bucar

Rhodiola rosea has been used in folk medicine as ethanolic macerates for a long time. This study aims to provide a quantitative and qualitative analysis and comparison of different ethanolic Rhodiola rosea rhizome macerates (35%, 70%, and 96% v/v) an...

  • Article
  • Open Access
25 Citations
5,062 Views
14 Pages

Phytochemical, Antibacterial and Antioxidant Activity Evaluation of Rhodiola crenulata

  • Lingyun Zhong,
  • Lianxin Peng,
  • Jia Fu,
  • Liang Zou,
  • Gang Zhao and
  • Jianglin Zhao

12 August 2020

The chemical components, as well as the antibacterial and antioxidant activities of the essential oil (EO) and crude extracts prepared from Rhodiola crenulata were investigated. The essential oil was separated by hydrodistillation, and gas chromatogr...

  • Article
  • Open Access
8 Citations
2,804 Views
13 Pages

Rhodiola rosea Reduces Intercellular Signaling in Campylobacter jejuni

  • Ajda Kunčič,
  • Franz Bucar and
  • Sonja Smole Možina

8 September 2022

Campylobacter jejuni is a major foodborne pathogen and the leading cause of bacterial gastroenteritis, i.e., campylobacteriosis. Besides searching for novel antimicrobials, identification of new targets for their action is becoming increasingly impor...

  • Article
  • Open Access
22 Citations
4,134 Views
18 Pages

Application of Natural Deep Eutectic Solvents for Extraction of Bioactive Components from Rhodiola rosea (L.)

  • Nikita Tsvetov,
  • Oksana Paukshta,
  • Nadezhda Fokina,
  • Natalia Volodina and
  • Artemiy Samarov

16 January 2023

Rhodiola rosea (L.) is a valuable source of nutrients. Nutrients have adaptogenic, immunostimulating, nootropic, anti-inflammatory and anti-cancer properties. Natural deep eutectic solvents (NADES) consisting of choline chloride and malonic, malic, t...

  • Article
  • Open Access
15 Citations
4,677 Views
17 Pages

Optimization of Biomass Accumulation and Production of Phenolic Compounds in Callus Cultures of Rhodiola rosea L. Using Design of Experiments

  • Anna A. Erst,
  • Anastasia A. Petruk,
  • Andrey S. Erst,
  • Denis A. Krivenko,
  • Nadezhda V. Filinova,
  • Svetlana Y. Maltseva,
  • Maxim S. Kulikovskiy and
  • Evgeny V. Banaev

2 January 2022

Rhodiola rosea L. is a valuable medicinal plant with adaptogenic, neuroprotective, antitumor, cardioprotective, and antidepressant effects. In this study, design of experiments methodology was employed to analyze and optimize the interacting effects...

  • Review
  • Open Access
46 Citations
19,346 Views
17 Pages

The roots and rhizomes of Rhodiola rosea L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds...

  • Article
  • Open Access
27 Citations
11,847 Views
20 Pages

11 May 2015

Rhodiola rosea (Rro) has been reported to have various pharmacological properties, including anti-fatigue, anti-stress and anti-inflammatory activity. It is also known to improve glucose and lipid metabolism, but the effects of Rhodiola rosea on adip...

  • Article
  • Open Access
8 Citations
3,728 Views
16 Pages

5 February 2023

Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible. The profil...

  • Article
  • Open Access
3,733 Views
17 Pages

Development of Orally Disintegrating Tablets of Standardized Rhodiola rosea Extract

  • Oxana Brante,
  • Rihards Talivaldis Bagons,
  • Santa Niedra,
  • Austris Mazurs,
  • Baiba Mauriņa,
  • Jurga Bernatoniene and
  • Konstantins Logviss

4 September 2025

Background/Objectives: Rhodiola rosea L. (Crassulaceae), a perennial adaptogenic herb native to Northern Europe, Asia, and North America, is renowned for its therapeutic properties attributed to phenolic compounds including flavonoids, phenyleth...

  • Article
  • Open Access
13 Citations
4,988 Views
22 Pages

Chemical Profiling and Biological Activity of Extracts from Nine Norwegian Medicinal and Aromatic Plants

  • Rune Slimestad,
  • Amritha Johny,
  • Mette Goul Thomsen,
  • Christian Renè Karlsen and
  • Jan Thomas Rosnes

28 October 2022

There is an increased interest in identifying beneficial compounds of plant origin that can be added to animal diets to improve animal performance and have a health-promoting effect. In the present study, nine herb species of the Norwegian wild flora...