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16 Results Found

  • Article
  • Open Access
25 Citations
5,180 Views
24 Pages

Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project

  • Nina Nauwelaerts,
  • Julia Macente,
  • Neel Deferm,
  • Rodolfo Hernandes Bonan,
  • Miao-Chan Huang,
  • Martje Van Neste,
  • David Bibi,
  • Justine Badee,
  • Frederico S. Martins and
  • Anne Smits
  • + 3 authors

Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacok...

  • Article
  • Open Access
1 Citations
2,523 Views
11 Pages

A Correlation Study of Plasma and Breast Milk Retinol Concentrations in Breastfeeding Women in China

  • Jing Qin,
  • Yubo Zhou,
  • Hongtian Li,
  • Ying Meng,
  • Sherry A. Tanumihardjo and
  • Jianmeng Liu

12 December 2023

Retinol in breast milk is related to plasma concentration among breastfeeding women, but the linear or curvilinear relationships between the two remains unclear. We conducted a cross-sectional study in 403 Chinese breastfeeding women at 42 ± 7...

  • Review
  • Open Access
8,966 Views
34 Pages

Breast milk provides significant health benefits to both infants and mothers, offering protection against infections and enhancing cognitive development. This paper examines the complex effects of substance use disorder (SUD) during pregnancy and lac...

  • Article
  • Open Access
17 Citations
4,953 Views
21 Pages

4 December 2018

Deoxynivalenol (DON) contamination of feed may result in reduced growth, feed refusal, immunosuppression, and health problems in swine. Piglets can be exposed to DON via placenta before birth and via milk during lactation. The extent of early-life ex...

  • Article
  • Open Access
3 Citations
2,562 Views
12 Pages

The Toxicokinetics, Excretion Patterns, and Milk Transmission of Ochratoxin A in Lactating Sows

  • Qiufeng Zhu,
  • Honglei Qu,
  • Ruifen Kang,
  • Yunduo Zheng,
  • Qiuying Guo,
  • Shimeng Huang,
  • Lihong Zhao and
  • Qiugang Ma

1 March 2024

Ochratoxin A (OTA), a mycotoxin commonly found in feedstuffs, is known for its detrimental effects on the kidneys and liver, posing significant health risks to animals and humans. This study investigated the toxicokinetics, excretion patterns, and mi...

  • Article
  • Open Access
3 Citations
3,778 Views
9 Pages

1 April 2020

Perfluoroalkyl carboxylic acids (PFCAs), such as perfluorooctanoic acid (PFOA, C8), are a group of industrial chemicals that are detected in the serum of people throughout the world. Long-chain PFCAs (C9 to C13) have high lipophilicity, therefore the...

  • Feature Paper
  • Article
  • Open Access
10 Citations
3,827 Views
16 Pages

PK/PD Analysis of Marbofloxacin by Monte Carlo Simulation against Mycoplasmaagalactiae in Plasma and Milk of Lactating Goats after IV, SC and SC-Long Acting Formulations Administration

  • Emilio Fernández-Varón,
  • Edgar García-Romero,
  • Juan M. Serrano-Rodríguez,
  • Carlos M. Cárceles,
  • Ana García-Galán,
  • Carlos Cárceles-García,
  • Rocío Fernández,
  • Cristina Muñoz and
  • Christian de la Fe

12 April 2021

Contagious agalactia is a mycoplasmosis affecting small ruminants that have become an important issue in many countries. However, PK/PD studies of antibiotics to treat this problem in lactating goats affected by Mycoplasma (M.) agalactiae, the main C...

  • Article
  • Open Access
8 Citations
3,189 Views
22 Pages

Alterations in Essential Fatty Acids, Immunoglobulins (IgA, IgG, and IgM), and Enteric Methane Emission in Primiparous Sows Fed Hemp Seed Oil and Their Offspring Response

  • Mihaela Hăbeanu,
  • Nicoleta Aurelia Lefter,
  • Anca Gheorghe,
  • Mariana Ropota,
  • Smaranda Mariana Toma,
  • Gina Cecilia Pistol,
  • Ioan Surdu and
  • Mihaela Dumitru

11 July 2022

This study shows the effects of dietary hemp seed oil on the milk composition, blood immunoglobulins (Ig), and enteric methane (E-CH4) production of primiparous sows, and their offspring’s response at three time points. A bifactorial experiment...

  • Article
  • Open Access
11 Citations
5,976 Views
11 Pages

16 February 2022

This study investigated the effects of the casein to whey proteins (CW) ratio in milk on body composition, muscle strength, and endurance exercise capacity in rats. Thirty rats were assigned into five groups, and each treatment was administered for e...

  • Article
  • Open Access
40 Citations
8,204 Views
14 Pages

Almond skins are a waste byproduct of blanched almond production. Polyphenols extracted from almond skins possess antioxidant activities in vitro and in vivo. Thus, we examined the pharmacokinetic profile of almond skin polyphenols (ASP) and their ef...

  • Article
  • Open Access
3 Citations
2,683 Views
14 Pages

24 October 2023

Appropriate protein sources are vital for the growth, development and health of neonates. Twenty–four 2–day–old piglets were randomly divided into three groups and fed isoenergetic and isonitrogenous diets. The experimental diets in...

  • Article
  • Open Access
8 Citations
6,506 Views
13 Pages

Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians

  • Namita Mahalle,
  • Vijayshri Bhide,
  • Eva Greibe,
  • Christian W. Heegaard,
  • Ebba Nexo,
  • Sergey N. Fedosov and
  • Sadanand Naik

1 February 2019

We assessed improvements in the vitamin B12 status of Indian lactovegetarians receiving four weeks supplementation with natural B12 in milk versus cyano-B12 in capsules. Three groups (n = 22, 23, 22) received daily oral doses of cyano-B12 (2 ×...

  • Article
  • Open Access
841 Views
11 Pages

Optimizing Cryopreservation of Pseudoplatystoma magdaleniatum Semen: Evaluation of Two Permeable and Two Non-Permeable Cryoprotectants

  • César Montes-Petro,
  • Betty Rodríguez-Peroza,
  • Diana Madariaga-Mendoza,
  • Carlos Tapia-Pacheco,
  • José Espinosa-Araujo and
  • Víctor Atencio-García

17 April 2025

The study aimed to evaluate the effectiveness of the cryopreservation protocols for Pseudoplatystoma magdaleniatum semen using dimethyl sulfoxide (DMSO) or methanol (MET) as permeable cryoprotectants at two concentrations (5% and 10%) combined with 1...

  • Article
  • Open Access
7 Citations
2,865 Views
14 Pages

19 August 2020

The aim of this study is to investigate the effect of the maternal diet with fish oil on the oxidative stress and inflammatory response in sows, and the protective effect on the piglets suckling the sows fed the diet with fish oil in the context of i...

  • Article
  • Open Access
47 Citations
6,465 Views
9 Pages

3 September 2018

Sodium (Na), potassium (K), and the ratio Na:K in human milk (HM) may be useful biomarkers to indicate secretory activation or inflammation in the breast. Previously, these elements have been measured in a laboratory setting requiring expensive equip...

  • Article
  • Open Access
7 Citations
3,124 Views
10 Pages

2 August 2023

The current study examined the effects of supplementary zinc proteinate (ZnPro) and zinc oxide (ZnO) on growth performance, diarrhea, antioxidant capacity, immune function, and mineral element concentrations of calves aged 1 to 28 days. A total of tw...