Skip to Content

21 Results Found

  • Article
  • Open Access
1 Citations
2,250 Views
16 Pages

Utility of Radiological Follow Up of Main-Duct Intraductal Papillary Mucinous Neoplasms and Mixed-Type Intraductal Papillary Mucinous Neoplasms

  • Roie Tzadok,
  • Rivka Kessner,
  • Einat Ritter,
  • Asaf Aizic and ,
  • Hila Yashar,
  • Sapir Lazar,
  • Yuval Katz,
  • Zur Ronen-Amsalem,
  • Arthur Chernomorets and
  • Dana Ben-Ami Shor
  • + 6 authors+ 1 author

Background: Intraductal papillary mucinous neoplasms (IPMNs) have the potential to evolve into pancreatic adenocarcinoma (PDAC). While main-duct IPMNs (MD-IPMNs), involving the main pancreatic duct (MPD), are less common than side-branch IPMNs (SB-IP...

(This article belongs to the Special Issue New Insights in Gastric, Colorectal, and Pancreatic Cancer)
  • Article
  • Open Access
1 Citations
617 Views
15 Pages

Feasibility of Peroral Pancreatoscopy Using the 9-Fr eyeMAX for Surgical Planning in Main-Duct and Mixed-Type Intraductal Papillary Mucinous Neoplasms

  • Haruo Miwa,
  • Kuniyasu Irie,
  • Tomoko Fujiyoshi,
  • Nene Sakai and ,
  • Ryo Soma,
  • Kozue Shibasaki,
  • Yugo Ishino,
  • Shotaro Tsunoda,
  • Yuto Matsuoka and
  • Shin Maeda
  • + 15 authors+ 10 authors

Background/Objectives: The role of peroral pancreatoscopy (POPS) in patients with main-duct and mixed-type intraductal papillary mucinous neoplasm (MD/mixed-IPMN) remains unclear. This retrospective multicenter case series aimed to evaluate the feasi...

(This article belongs to the Special Issue New Insights into Endoscopy-Guided Diagnosis)
  • Systematic Review
  • Open Access
22 Citations
5,535 Views
13 Pages

Ductal Dilatation of ≥5 mm in Intraductal Papillary Mucinous Neoplasm Should Trigger the Consideration for Pancreatectomy: A Meta-Analysis and Systematic Review of Resected Cases

  • Y.H. Andrew Wu,
  • Atsushi Oba,
  • Laurel Beaty,
  • Kathryn L. Colborn and ,
  • Salvador Rodriguez Franco,
  • Ben Harnke,
  • Cheryl Meguid,
  • Daniel Negrini,
  • Roberto Valente and
  • Marco Del Chiaro
  • + 7 authors+ 2 authors

22 April 2021

Intraductal papillary mucinous neoplasms (IPMN) are common but difficult to manage since accurate tools for diagnosing malignancy are unavailable. This study tests the diagnostic value of the main pancreatic duct (MPD) diameter for detecting IPMN mal...

(This article belongs to the Special Issue Surgical Treatment of Pancreatic Ductal Adenocarcinoma)
  • Article
  • Open Access
4 Citations
3,270 Views
13 Pages

Histological Subtypes Might Help Risk Stratification in Different Morphological Types of IPMNs: Back to the Future?

  • Giuseppe Anzillotti,
  • Francesca Vespasiano,
  • Chiara Maria Scandavini,
  • Marco Del Chiaro and ,
  • Asif Halimi,
  • Alessandro Anselmo,
  • Giuseppe Tisone,
  • Carlos Fernández Moro,
  • Zeeshan Ateeb and
  • Roberto Valente
  • + 8 authors+ 3 authors

10 November 2024

Background: Intraductal papillary mucinous neoplasms (IPMNs) display four histological subtypes: gastric foveolar, pancreaticobiliary, intestinal, and oncocytic. All of these subtypes harbor a different risk of cancer development. The clinical impact...

(This article belongs to the Section General Surgery)
  • Review
  • Open Access
16 Citations
10,873 Views
15 Pages

Pancreatic Cystic Neoplasms: Translating Guidelines into Clinical Practice

  • Sonmoon Mohapatra,
  • Somashekar G. Krishna and
  • Rahul Pannala

16 February 2023

A combination of several factors, including the increasing use of cross-sectional imaging and an aging population, has led to pancreatic cystic lesions (PCLs) becoming the most detected incidental pancreatic lesions. Accurate diagnosis and risk strat...

(This article belongs to the Special Issue Diagnosis and Management of Pancreatic Cysts)
  • Review
  • Open Access
9 Citations
14,695 Views
20 Pages

Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Challenging Diagnosis

  • Charikleia Triantopoulou,
  • Sofia Gourtsoyianni,
  • Dimitriοs Karakaxas and
  • Spiros Delis

Intraductal papillary mucinous neoplasm of the pancreas (IPMN) was classified as a distinct entity from mucinous cystic neoplasm by the WHO in 1995. It represents a mucin-producing tumor that originates from the ductal epithelium and can evolve from...

(This article belongs to the Special Issue Imaging Diagnosis in Abdomen)
  • Review
  • Open Access
19 Citations
5,224 Views
16 Pages

Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification

  • Vincenzo Nasca,
  • Marta Chiaravalli,
  • Geny Piro,
  • Annachiara Esposito and ,
  • Lisa Salvatore,
  • Giampaolo Tortora,
  • Vincenzo Corbo and
  • Carmine Carbone
  • + 3 authors+ 0 author

2 September 2020

Pancreatic ductal adenocarcinoma is one of the most lethal human cancers. Its precursor lesions include pancreatic intra-epithelial neoplasia, mucinous cystic neoplasm, and intraductal papillary mucinous neoplasm (IPMN). IPMNs usually present as an i...

(This article belongs to the Special Issue Pancreatic Ductal Adenocarcinoma: Precursors and Variants)
  • Review
  • Open Access
7 Citations
7,286 Views
21 Pages

Diagnostic, Structured Classification and Therapeutic Approach in Cystic Pancreatic Lesions: Systematic Findings with Regard to the European Guidelines

  • Christopher Kloth,
  • Benedikt Haggenmüller,
  • Annika Beck,
  • Martin Wagner and ,
  • Marko Kornmann,
  • Jochen P. Steinacker,
  • Nora Steinacker-Stanescu,
  • Daniel Vogele,
  • Meinrad Beer and
  • Stefan A. Schmidt
  • + 6 authors+ 1 author

Due to the increasing use of cross-sectional imaging techniques and new technical possibilities, the number of incidentally detected cystic lesions of the pancreas is rapidly increasing in everyday radiological routines. Precise and rapid classificat...

(This article belongs to the Special Issue Advances in the Diagnostic Imaging of Gastrointestinal Diseases)
  • Article
  • Open Access
26 Citations
6,016 Views
17 Pages

Predictive Features of Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Meta-Analysis

  • Wooil Kwon,
  • Youngmin Han,
  • Yoonhyeong Byun,
  • Jae Seung Kang and ,
  • Yoo Jin Choi,
  • Hongbeom Kim and
  • Jin-Young Jang
  • + 2 authors+ 0 author

14 September 2020

The current guidelines on branch duct type intraductal papillary mucinous neoplasm (BD-IPMN) recommend various predictive features of malignancy as well as different treatment strategies. This study aimed to identify the risk factors for malignancy w...

(This article belongs to the Special Issue Surgical Treatment of Pancreatic Ductal Adenocarcinoma)
  • Review
  • Open Access
34 Citations
8,947 Views
17 Pages

Humoral Predictors of Malignancy in IPMN: A Review of the Literature

  • Enrico C. Nista,
  • Tommaso Schepis,
  • Marcello Candelli,
  • Lucia Giuli and ,
  • Giulia Pignataro,
  • Francesco Franceschi,
  • Antonio Gasbarrini and
  • Veronica Ojetti
  • + 3 authors+ 0 author

27 November 2021

Pancreatic cystic lesions are increasingly detected in cross-sectional imaging. Intraductal papillary mucinous neoplasm (IPMN) is a mucin-producing subtype of the pancreatic cyst lesions arising from the pancreatic duct system. IPMN is a potential pr...

(This article belongs to the Special Issue Focus on Gastrointestinal Diseases)
  • Review
  • Open Access
15 Citations
5,192 Views
14 Pages

Application of Artificial Intelligence in the Management of Pancreatic Cystic Lesions

  • Shiva Rangwani,
  • Devarshi R. Ardeshna,
  • Brandon Rodgers,
  • Jared Melnychuk and ,
  • Ronald Turner,
  • Stacey Culp,
  • Wei-Lun Chao and
  • Somashekar G. Krishna
  • + 3 authors+ 0 author

The rate of incidentally detected pancreatic cystic lesions (PCLs) has increased over the past decade and was recently reported at 8%. These lesions pose a unique challenge, as each subtype of PCL carries a different risk of malignant transformation,...

(This article belongs to the Special Issue Artificial Intelligence (AI))
  • Article
  • Open Access
3 Citations
2,847 Views
9 Pages

Efficacy and Safety of Pancreatic Juice Cytology with Synthetic Secretin in Diagnosing Malignant Intraductal Papillary Mucinous Neoplasms of the Pancreas

  • Yohei Takeda,
  • Kazuya Matsumoto,
  • Takumi Onoyama,
  • Taro Yamashita and ,
  • Hiroki Koda,
  • Wataru Hamamoto,
  • Yuri Sakamoto,
  • Takuya Shimosaka,
  • Shiho Kawahara and
  • Hajime Isomoto
  • + 6 authors+ 1 author

The risk of malignant transformation of intraductal papillary mucinous neoplasm (IPMN) is presently assessed using imaging, which remains unsatisfactory. Given the high viscosity of pancreatic juice, pancreatic juice cytology (PJC) is considered an i...

(This article belongs to the Special Issue Advances in Diagnostic Cytopathology)
  • Review
  • Open Access
42 Citations
6,631 Views
22 Pages

Pre-Operative Imaging and Pathological Diagnosis of Localized High-Grade Pancreatic Intra-Epithelial Neoplasia without Invasive Carcinoma

  • Ryota Sagami,
  • Kentaro Yamao,
  • Jun Nakahodo,
  • Ryuki Minami and ,
  • Masakatsu Tsurusaki,
  • Kazunari Murakami and
  • Yuji Amano
  • + 2 authors+ 0 author

24 February 2021

Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions, such as pancreatic intra-epithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). The prognosis of high-grade precancerous lesions, including high-grade Pa...

(This article belongs to the Special Issue Advances in Pancreatic Cancer Imaging)
  • Review
  • Open Access
51 Citations
26,088 Views
9 Pages

The Role of Transabdominal Ultrasound in the Diagnosis of Early Stage Pancreatic Cancer: Review and Single-Center Experience

  • Reiko Ashida,
  • Sachiko Tanaka,
  • Hiromi Yamanaka,
  • Suetsumi Okagaki and ,
  • Keiko Nakao,
  • Junko Fukuda,
  • Miho Nakao,
  • Tatsuya Ioka and
  • Kazuhiro Katayama
  • + 4 authors+ 0 author

Pancreatic cancer (PC) is the fourth leading cause of cancer-related death with a 5-year survival rate less than 10%. In the absence of effective screening methods, such as blood markers, most clinical diagnoses of PC are made at an advanced stage. H...

(This article belongs to the Special Issue Early Diagnosis of Pancreatic Cancer)
  • Review
  • Open Access
13 Citations
7,615 Views
22 Pages

An Overview for Clinicians on Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas

  • Dimitrios Moris,
  • Ioannis Liapis,
  • Piyush Gupta,
  • Ioannis A. Ziogas and ,
  • Georgia-Sofia Karachaliou,
  • Nikolaos Dimitrokallis,
  • Brian Nguyen and
  • Pejman Radkani
  • + 3 authors+ 0 author

14 November 2024

Currently, there is no reliable method of discerning between low-risk and high-risk intraductal papillary mucinous neoplasms (IPMNs). Operative resection is utilized in an effort to resect those lesions with high-grade dysplasia (HGD) prior to the de...

(This article belongs to the Special Issue Advanced Research in Oncology in 2024)
  • Review
  • Open Access
2,316 Views
29 Pages

Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas: History, Myths, and Realities Between Past and Future

  • Riccardo Urgesi,
  • Cristiano Pagnini,
  • Maria Carla Di Paolo,
  • Lorella Pallotta and ,
  • Gianfranco Fanello,
  • Pavlos Antypas,
  • Elio Pietro Perrone,
  • Giuseppe Villotti,
  • Andrea D’Amico and
  • Maria Giovanna Graziani
  • + 6 authors+ 1 author

19 July 2026

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is among the most clinically relevant and conceptually intricate precancerous lesions encountered in modern gastroenterology. First identified in the early 1980s as a “mucin-produci...

(This article belongs to the Section Hepatic and Gastroenterology Diseases)
  • Article
  • Open Access
5 Citations
6,342 Views
19 Pages

Single-Breath-Hold MRI-SPACE Cholangiopancreatography with Compressed Sensing versus Conventional Respiratory-Triggered MRI-SPACE Cholangiopancreatography at 3Tesla: Comparison of Image Quality and Diagnostic Confidence

  • Olivier Chevallier,
  • Hélène Escande,
  • Khalid Ambarki,
  • Elisabeth Weiland and ,
  • Bernd Kuehn,
  • Kévin Guillen,
  • Sylvain Manfredi,
  • Sophie Gehin,
  • Julie Blanc and
  • Romaric Loffroy
  • + 5 authors+ 0 author

13 October 2021

To compare two magnetic resonance cholangiopancreatography (MRCP) sequences at 3 Tesla (3T): the conventional 3D Respiratory-Triggered SPACE sequence (RT-MRCP) and a prototype 3D Compressed-Sensing Breath-Hold SPACE sequence (CS-BH-MRCP), in terms of...

(This article belongs to the Special Issue Advances and Novelties in Hepatobiliary and Pancreatic Imaging)
  • Article
  • Open Access
1 Citations
3,081 Views
15 Pages

Clinical Features of Intraductal Papillary Mucinous Neoplasm-Related Pancreatic Carcinomas in Long-Term Surveillance

  • Kyohei Matsuura,
  • Shinsaku Nagamatsu,
  • Shoma Kikukawa,
  • Yuya Nishio and ,
  • Yusuke Komeda,
  • Yuya Matsuo,
  • Kohei Ohta,
  • Chisa Yamamoto,
  • Ayana Sueki and
  • Kei Moriya
  • + 5 authors+ 0 author

27 June 2025

Background and Aims: An appropriate surveillance system must be established to efficiently identify cases of intraductal papillary mucinous neoplasm (IPMN)-related malignant transformation. We analyzed the initial clinical background that affects lon...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
6 Citations
9,595 Views
28 Pages

Pancreatic Cancer Detection in Intraductal Papillary Mucinous Neoplasm (IPMN)—New Insights

  • Wojciech Pawłowski,
  • Mateusz Stefański,
  • Barbara Włodarczyk,
  • Łukasz Durko and
  • Ewa Małecka-Wojciesko

16 October 2025

Early diagnosis of pancreatic cancer, particularly in intraductal papillary mucinous neoplasm (IPMN), remains challenging despite advances in imaging and biomarkers. Pancreatic adenocarcinoma (PDAC) has a high mortality rate; therefore, its early det...

(This article belongs to the Section Methods and Technologies Development)
  • Review
  • Open Access
404 Views
13 Pages

Peroral Pancreatoscopy for Differentiating Main Duct IPMN from Chronic Pancreatitis: A Narrative Review and a Case Series

  • Federica Fimiano,
  • Annachiara De Conte,
  • Carmela Abbatiello,
  • Elio Donnarumma and ,
  • Mario Gagliardi,
  • Michele Fusco,
  • Giuseppina Pontillo,
  • Mariano Sica and
  • Claudio Zulli
  • + 4 authors+ 0 author

19 August 2026

Main pancreatic duct (MPD) dilatation may occur in both main-duct intraductal papillary mucinous neoplasm (MD-IPMN) and chronic pancreatitis (CP). In selected patients, MRI/MRCP, endoscopic ultrasonography (EUS), and contrast-enhanced EUS may remain...

(This article belongs to the Special Issue Clinical Advances in Gastrointestinal Endoscopy)
  • Article
  • Open Access
332 Views
15 Pages

Neutrophil-to-Lymphocyte Ratio Is Associated with Disease Progression in a Surveillance Cohort of Patients with Branch-Duct IPMN

  • Frederik J. Hansen,
  • Peter Ewald,
  • Luis Sorncharoen,
  • Daniel R. Quast and ,
  • Maximilian Stögbauer,
  • Christian Torres Reyes,
  • Renate Schlottmann,
  • Christoph Zeidler,
  • Mousa Ayoub and
  • Alanna Ebigbo
  • + 10 authors+ 5 authors

8 October 2026

Background: A Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) are common pancreatic precursor lesions requiring varying duration of surveillance because of their potential for malignant transformation. Current risk stratification reli...

(This article belongs to the Special Issue Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition)