New Insights into Endoscopy-Guided Diagnosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 619

Special Issue Editor

Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan
Interests: gastrointestinal disease; pancreatobiliary disease; magnifying endoscope; endoscopic ultrasonography; peroral cholangiopancreatography; endo-hepatology; artificial intelligence

Special Issue Information

Dear Colleagues, 

I am delighted to introduce a collection dedicated to exploring “Novel Methods in Endoscopy-Guided Diagnosis” for patients with gastrointestinal, hepatic, and pancreatobiliary diseases. Endoscopy continues to evolve as a cornerstone of precision medicine, offering innovative diagnostic possibilities. This Special Issue focuses particularly on advanced techniques in magnifying endoscopy, endoscopic ultrasonography (EUS), peroral cholangiopancreatoscopy, and artificial intelligence-guided endoscopy. It not only highlights advanced imaging techniques but also details various methods for tissue sampling, such as biopsies for gastrointestinal diseases, EUS-guided tissue acquisition, and cholangiopancreatoscopy-guided biopsies. These innovative approaches are transforming clinical practice and improving diagnostic accuracy. We welcome original research articles, case studies, case reports, and reviews on the various novel approaches that deepen our understanding of the role of endoscopy in challenging diseases.

Dr. Haruo Miwa
Guest Editor

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Keywords

  • gastrointestinal disease
  • pancreatobiliary disease
  • magnifying endoscope
  • endoscopic ultrasonography
  • peroral cholangiopancreatography
  • endo-hepatology
  • artificial intelligence

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Published Papers (1 paper)

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Research

14 pages, 3811 KB  
Article
Ultrasonography Elastography to Predict the Diagnosis, Severity, and Treatment Indication of Esophageal Varices in Patients with Chronic Liver Diseases
by Azusa Wada, Yasunobu Yamashita, Mikitaka Iguchi, Yoshiyuki Ida, Takao Maekita, Reiko Ashida and Masayuki Kitano
Diagnostics 2025, 15(15), 1867; https://doi.org/10.3390/diagnostics15151867 - 25 Jul 2025
Viewed by 433
Abstract
Background/Objectives: Esophageal varices (EVs) are a serious complication of liver cirrhosis. Guidelines for cirrhosis/chronic liver diseases (CLDs) do not specify a follow-up period or the need for esophagogastroduodenoscopy (EGD). EGD is a useful but uncomfortable procedure for the assessment of varices. Follow-up [...] Read more.
Background/Objectives: Esophageal varices (EVs) are a serious complication of liver cirrhosis. Guidelines for cirrhosis/chronic liver diseases (CLDs) do not specify a follow-up period or the need for esophagogastroduodenoscopy (EGD). EGD is a useful but uncomfortable procedure for the assessment of varices. Follow-up with abdominal ultrasonography (AUS) is recommended in patients with CLDs. If EVs are assessed by AUS, more patients eligible for endoscopic screening of EVs can be selected. We aimed to investigate whether AUS elastography [shear wave (Vs) and F-index] can predict the diagnosis, severity, and treatment indication of EVs. Methods: Between April 2018 and October 2022, we retrospectively collected data of 194 patients who underwent elastography and EGD for CLDs. The correlations between Vs/F-index values and presence/severity of EVs were evaluated. Each cut-off value for diagnosis and treatment indication of EVs was investigated. Results: 85 patients without exclusion criteria were enrolled. Vs and F-index values were significantly higher in patients with EVs than in patients without EVs (p = 0.0005 and 0.0021, respectively) and positively correlated with severity of EVs. The cut-off Vs and F-index values for the presence of EVs were 1.63 m/s and 1.88, respectively, with 88.1%/83.3% sensitivity, 48.8%/51.2% specificity, and 0.71/0.70 area under the curve (AUC). The cut-off Vs and F-index values for treatment indication were 1.71 m/s and 2.08, respectively, with 100%/88.2% sensitivity, 45.6%/52.9% specificity, and 0.69/0.70 AUC. There were no significant differences between the two modalities. Conclusions: Elastography may provide objective assessment and thus be a non-invasive screening tool for diagnosis and treatment indication of EVs. Full article
(This article belongs to the Special Issue New Insights into Endoscopy-Guided Diagnosis)
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