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10 Results Found

  • Brief Report
  • Open Access
2 Citations
2,654 Views
13 Pages

An Assessment of the Currently Available Molecular Assay for the Diagnosis of Anisakis Sensitization

  • Maria Barrale,
  • Walter Mazzucco,
  • Santo Fruscione,
  • Maurizio Zarcone and ,
  • Vincenzo Cantisano,
  • Gaetano Cammilleri,
  • Antonella Costa,
  • Vincenzo Ferrantelli,
  • Rosa Onida and
  • Ignazio Brusca
  • + 8 authors+ 3 authors

The diagnosis of allergic reactions to Anisakis remains challenging due to the lack of specific allergens available for routine clinical use. However, the latest version of the multiplex macroarray ALEX-2 now allows the detection of specific IgE agai...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
2,282 Views
17 Pages

SKA3 Expression as a Prognostic Factor for Patients with Pancreatic Adenocarcinoma

  • Karolina Buchholz,
  • Justyna Durślewicz,
  • Anna Klimaszewska-Wiśniewska,
  • Magdalena Wiśniewska and ,
  • Maciej Słupski and
  • Dariusz Grzanka
  • + 1 author+ 0 author

The spindle and kinetochore-associated complex subunit 3 (SKA3) is a protein essential for proper chromosome segregation during mitosis and thus responsible for maintaining genome stability. Although its involvement in the pathogenesis of various can...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
6 Citations
2,972 Views
21 Pages

Molecular Signatures of Aeroallergen Sensitization in Pediatric Populations: A Comparative Study Across Spanish Cities

  • Ana Martínez-Cañavate,
  • María Mesa-Del-Castillo,
  • Francisco Carballada,
  • Cristina Rivas-Juesas and ,
  • José Ángel Porto,
  • Cristina Blasco,
  • Montserrat Álvaro-Lozano,
  • Jaime Lozano,
  • Julián Andrés Manrique and
  • Miguel Tortajada-Girbés
  • + 14 authors+ 9 authors

Spain exhibits significant climatic variability across its regions, ranging from the humid oceanic climate in the north to the Mediterranean and stepped climates in the southern and central areas. These climatic differences influence environmental al...

(This article belongs to the Section Molecular Immunology)
  • Article
  • Open Access
29 Citations
5,436 Views
16 Pages

Distinct DNA Methylation Profiles in Ovarian Tumors: Opportunities for Novel Biomarkers

  • Lorena Losi,
  • Sergio Fonda,
  • Sara Saponaro,
  • Sonia T. Chelbi and ,
  • Cesare Lancellotti,
  • Gaia Gozzi,
  • Loredana Alberti,
  • Luca Fabbiani,
  • Laura Botticelli and
  • Jean Benhattar
  • + 5 authors+ 0 author

Aberrant methylation of multiple promoter CpG islands could be related to the biology of ovarian tumors and its determination could help to improve treatment strategies. DNA methylation profiling was performed using the Methylation Ligation-dependent...

(This article belongs to the Special Issue Ovarian Cancer: Pathogenesis, Diagnosis, and Treatment)
  • Article
  • Open Access
9 Citations
5,891 Views
16 Pages

Sugarcane Serine Peptidase Inhibitors, Serine Peptidases, and Clp Protease System Subunits Associated with Sugarcane Borer (Diatraea saccharalis) Herbivory and Wounding

  • Ane H. Medeiros,
  • Fabiana B. Mingossi,
  • Renata O. Dias,
  • Flávia P. Franco and ,
  • Renato Vicentini,
  • Marcia O. Mello,
  • Daniel S. Moura and
  • Marcio C. Silva-Filho
  • + 3 authors+ 0 author

1 September 2016

Sugarcane’s (Saccharum spp.) response to Diatraea saccharalis (F.) (Lepidoptera: (Crambidae) herbivory was investigated using a macroarray spotted with 248 sugarcane Expressed Sequence Tags (ESTs) encoding serine peptidase inhibitors, serine peptidas...

(This article belongs to the Special Issue Plant-Insect Interactions)
  • Article
  • Open Access
22 Citations
4,701 Views
19 Pages

Expression of Genomic Instability-Related Molecules: Cyclin F, RRM2 and SPDL1 and Their Prognostic Significance in Pancreatic Adenocarcinoma

  • Anna Klimaszewska-Wiśniewska,
  • Karolina Buchholz,
  • Izabela Neska-Długosz,
  • Justyna Durślewicz and ,
  • Dariusz Grzanka,
  • Jan Zabrzyński,
  • Paulina Sopońska,
  • Alina Grzanka and
  • Maciej Gagat
  • + 4 authors+ 0 author

18 February 2021

In the present study, we aimed to assess the selected components of cell cycle machinery, checkpoint, DNA repair, and synthesis, namely RRM2, cyclin F, and SPDL1 in pancreatic adenocarcinomas (PAC) by in-house immunohistochemistry (IHC) and bioinform...

  • Brief Report
  • Open Access
4 Citations
3,563 Views
14 Pages

Multiplex Proteomic Evaluation in Inborn Errors with Deregulated IgE Response

  • Enrico Scala,
  • Stefania Madonna,
  • Daniele Castiglia,
  • Alessandro Scala and ,
  • Elisabetta Caprini and
  • Roberto Paganelli
  • + 1 author+ 0 author

(1) Background: Atopic dermatitis constitutes one of the most common inflammatory skin manifestations of the pediatric population. The onset of many inborn errors occurs early in life with an AD–like picture associated with a deregulated IgE re...

(This article belongs to the Special Issue Clinical Immunology in Italy, with Special Emphasis to Primary and Acquired Immunodeficiencies: A Commemorative Issue in Honor of Prof. Fernando Aiuti)
  • Article
  • Open Access
2,928 Views
26 Pages

Prognostic Significance of SATB1, SMAD3, Ezrin and β-Catenin in Patients with Pancreatic Adenocarcinoma

  • Justyna Durślewicz,
  • Anna Klimaszewska-Wiśniewska,
  • Ewa Domanowska,
  • Natalia Skoczylas-Makowska and ,
  • Paulina Antosik,
  • Wioletta Zielińska,
  • Arkadiusz Gzil,
  • Paulina Czajkowska,
  • Klaudia Mikołajczyk and
  • Dariusz Grzanka
  • + 5 authors+ 0 author

29 December 2021

The present study aimed to explore the role of SATB1, SMAD3, Ezrin and β-catenin as individual and combined biomarkers for the survival prediction in pancreatic adenocarcinoma (PAC). Notably, this study distinguished for the first time a potenti...

(This article belongs to the Special Issue Recent Developments and Emerging Trends in Cytoskeletal and Cell Cycle Proteins)
  • Article
  • Open Access
1,484 Views
17 Pages

Evaluation of GDF15 Significance as a Biomarker in Laryngeal Squamous Cell Carcinoma

  • Aleksandra Romanowicz,
  • Oskar Komisarek,
  • Anna Klimaszewska-Wiśniewska,
  • Paulina Antosik and ,
  • Kacper Naglik,
  • Joanna Czech,
  • Witold Wrzesiński,
  • Marta Kodzik,
  • Magdalena Bodnar and
  • Paweł Burduk
  • + 6 authors+ 1 author

9 July 2025

Background/Objectives: Laryngeal squamous cell carcinoma (LSCC) is a common malignancy with unsatisfactory survival rates, highlighting the need for reliable biomarkers to improve its diagnosis and prognosis. Growth differentiation factor 15 (GDF15),...

(This article belongs to the Special Issue Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery)
  • Article
  • Open Access
1,752 Views
19 Pages

25 February 2025

Background/Objectives: Endometrial cancer (EC) is a heterogeneous gynecological malignancy characterized by varied clinical outcomes and complex molecular mechanisms. The dysregulation of cyclin K (CCNK), a key regulator of transcription and cell cyc...

(This article belongs to the Section Molecular Cancer Biology)